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Prevalence of Apoli...
Prevalence of Apolipoprotein E Polymorphisms in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly : A Northern Greece Study
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- Tsolaki, Anthoula C. (författare)
- 1st Gen Hosp Thessaloniki Agios Pavlos, Neurol Clin, Ellis Alexiou 19, GR-55134 Thessaloniki, Greece;Greek Assoc Alzheimers Dis & Related Disorders, Thessaloniki, Greece;Aristotle Univ Thessaloniki, Med Phys Lab, Med Sch, Thessaloniki, Greece
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- Gatzima, Olympia (författare)
- Greek Assoc Alzheimers Dis & Related Disorders, Thessaloniki, Greece
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- Daniilidou, Makrina (författare)
- Uppsala universitet,Neurologi,Uppsala Univ, Akad Hosp, Uppsala, Sweden
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- Lazarou, Eutuxia (författare)
- Aristotle Univ Thessaloniki, Dept Neurol 1, Thessaloniki, Greece;Greek Assoc Alzheimers Dis & Related Disorders, Thessaloniki, Greece
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- Bamidis, Panagiotis D. (författare)
- Aristotle Univ Thessaloniki, Med Phys Lab, Med Sch, Thessaloniki, Greece
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- Verykouki, Eleni (författare)
- Aristotle Univ Thessaloniki, Med Sch, Dept Hyg Social Prevent Med & Med Stat, Thessaloniki, Greece
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- Iakovidou-Kritsi, Zafiroura (författare)
- Aristotle Univ Thessaloniki, Dept Med, Lab Med Biol Genet, Thessaloniki, Greece
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- Tsolaki, Magda (författare)
- Aristotle Univ Thessaloniki, Dept Neurol 1, Thessaloniki, Greece;Greek Assoc Alzheimers Dis & Related Disorders, Thessaloniki, Greece
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(creator_code:org_t)
- 2018-09-11
- 2018
- Engelska.
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Ingår i: Neurodegenerative Diseases. - : S. Karger. - 1660-2854 .- 1660-2862. ; 18:4, s. 216-224
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Apolipoprotein E epsilon 4 allele (APOE epsilon 4) is a major genetic risk factor for Alzheimer's disease (AD). APOE epsilon 4 carriers have a higher risk of cognitive impairment and AD in a gene dose-dependent manner. The above notion is investigated in the Greek population. Methods: A sample of 1,703 subjects (967 AD patients, 576 mild cognitive impairment [MCI] and 160 Healthy Elderly), was genotyped for APOE from 2008 to 2017. DNA was extracted from peripheral blood using the QIAamp Blood DNA purification kit (Qiagen Inc., USA). Descriptive statistics, one-way analysis of variance with Bonferroni post hoc tests, Pearson chi-square test, and binary logistic regression models were used for the statistical analysis. Results: The APOE genotype and allele frequencies in AD group were significantly different from those in the Control and MCI groups. The frequencies of epsilon 4/4 homozygotes were 1.9, 1.6, and 5.7%, while the epsilon 4/- carriers' distribution was 22.5, 24.1, and 37.4% in the Control, MCI, and AD groups respectively. The estimated odds of epsilon 4/4 for AD was 5.731-fold higher compared to the estimated odds of epsilon 3/3. The interaction between gender and APOE did not have a significant effect on the odds for MCI (p = 0.942) and AD (p = 0.984). Conclusion: In Greece, APOE epsilon 4 presence is related to an increased risk for AD in a dose-related manner. Contrary to long-standing views, men and women with the APOE epsilon 4 genotype have nearly the same odds of developing MCI and AD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Alzheimer's disease
- Mild cognitive impairment
- Apolipoprotein E
- Greek population
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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