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Molecular pathways behind acquired obesity : Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI

van der Kolk, Birgitta W. (author)
Univ Helsinki, Fac Med, Obes Res Unit, Res Program Clin & Mol Metab, Helsinki, Finland.
Saari, Sina (author)
Univ Helsinki, Fac Med, Obes Res Unit, Res Program Clin & Mol Metab, Helsinki, Finland.
Lovric, Alen (author)
KTH,Science for Life Laboratory, SciLifeLab,Karolinska Univ Hosp, Karolinska Inst, Dept Lab Med, Div Clin Physiol, Stockholm, Sweden.;Karolinska Univ Hosp, Unit Clin Physiol, Stockholm, Sweden.
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Arif, Muhammad (author)
KTH,Systembiologi
Alvarez, Marcus (author)
Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA.
Ko, Arthur (author)
Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
Miao, Zong (author)
Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA.;Univ Calif Los Angeles, Bioinformat Interdept Program, Los Angeles, CA USA.
Sahebekhtiari, Navid (author)
Univ Helsinki, Fac Med, Obes Res Unit, Res Program Clin & Mol Metab, Helsinki, Finland.
Muniandy, Maheswary (author)
Univ Helsinki, Fac Med, Obes Res Unit, Res Program Clin & Mol Metab, Helsinki, Finland.
Heinonen, Sini (author)
Univ Helsinki, Fac Med, Obes Res Unit, Res Program Clin & Mol Metab, Helsinki, Finland.
Oghabian, Ali (author)
Univ Helsinki, Fac Med, Obes Res Unit, Res Program Clin & Mol Metab, Helsinki, Finland.
Jokinen, Riikka (author)
Univ Helsinki, Fac Med, Obes Res Unit, Res Program Clin & Mol Metab, Helsinki, Finland.
Jukarainen, Sakari (author)
Univ Helsinki, Inst Mol Med Finland, FIMM, Helsinki, Finland.
Hakkarainen, Antti (author)
Univ Helsinki, HUS Med Imaging Ctr, Radiol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
Lundbom, Jesper (author)
Univ Helsinki, HUS Med Imaging Ctr, Radiol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.;Heinrich Heine Univ, German Diabet Ctr, Leibniz Ctr Diabet Res, Inst Clin Diabetol, Dusseldorf, Germany.
Kuula, Juho (author)
Univ Helsinki, HUS Med Imaging Ctr, Radiol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.;Natl Inst Hlth & Welf, Publ Hlth Promot Unit, Helsinki, Finland.
Groop, Per-Henrik (author)
Helsinki Univ Hosp, Helsinki, Finland.;Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland.;Univ Helsinki, Fac Med, Res Program Clin & Mol Metab, Helsinki, Finland.;Univ Helsinki, Abdominal Ctr, Nephrol, Helsinki, Finland.;Monash Univ, Cent Clin Sch, Dept Diabet, Melbourne, Vic, Australia.
Tukiainen, Taru (author)
Univ Helsinki, Inst Mol Med Finland, FIMM, Helsinki, Finland.
Lundbom, Nina (author)
Univ Helsinki, HUS Med Imaging Ctr, Radiol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
Rissanen, Aila (author)
Univ Helsinki, Fac Med, Obes Res Unit, Res Program Clin & Mol Metab, Helsinki, Finland.
Kaprio, Jaakko (author)
Univ Helsinki, Inst Mol Med Finland, FIMM, Helsinki, Finland.
Williams, Evan G. (author)
Swiss Fed Inst Technol, Inst Mol Syst Biol, Zurich, Switzerland.
Zamboni, Nicola (author)
Swiss Fed Inst Technol, Inst Mol Syst Biol, Zurich, Switzerland.
Mardinoglu, Adil (author)
KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kings Coll London, Ctr Host Microbiome Interact, Dent Inst, London, England.
Pajukanta, Paivi (author)
Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA.;Univ Calif Los Angeles, Bioinformat Interdept Program, Los Angeles, CA USA.;Univ Calif Los Angeles, David Geffen Sch Med, Inst Precis Hlth, Los Angeles, CA 90095 USA.
Pietilainen, Kirsi H. (author)
Univ Helsinki, Fac Med, Obes Res Unit, Res Program Clin & Mol Metab, Helsinki, Finland.;Helsinki Univ Hosp, Obes Ctr, Abdominal Ctr, Helsinki, Finland.
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Univ Helsinki, Fac Med, Obes Res Unit, Res Program Clin & Mol Metab, Helsinki, Finland Science for Life Laboratory, SciLifeLab (creator_code:org_t)
Elsevier BV, 2021
2021
English.
In: Cell Reports Medicine. - : Elsevier BV. - 2666-3791. ; 2:4, s. 100226-
Related links:
https://doi.org/10.1...
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https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Tissue-specific mechanisms prompting obesity-related development complications in humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and skeletal muscle to examine the effects of acquired obesity among 49 BMI-discordant monozygotic twin pairs. Overall, adipose tissue appears to be more affected by excess body weight than skeletal muscle. In heavier co-twins, we observe a transcriptional pattern of downregulated mitochondrial pathways in both tissues and upregulated inflammatory pathways in adipose tissue. In adipose tissue, heavier co-twins exhibit lower creatine levels; in skeletal muscle, glycolysis- and redox stress-related protein and metabolite levels remain higher. Furthermore, metabolomics analyses in both tissues reveal that several proinflammatory lipids are higher and six of the same lipid derivatives are lower in acquired obesity. Finally, in adipose tissue, but not in skeletal muscle, mitochondrial downregulation and upregulated inflammation are associated with a fatty liver, insulin resistance, and dyslipidemia, suggesting that adipose tissue dominates in acquired obesity.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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