Sökning: WFRF:(Tumkur Sitaram Raviprakash 1974 ) >
Human PRH1, PRH2 su...
Human PRH1, PRH2 susceptibility and resistance and Streptococcus mutans virulence phenotypes specify different microbial profiles in caries
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- Sheng, Nongfei, 1988- (författare)
- Umeå universitet,Institutionen för odontologi,Department of Odontology/Cariology, Umeå University, 901 87, Umeå, Sweden
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- Mårell, Lena, 1957- (författare)
- Umeå universitet,Institutionen för odontologi,Department of Odontology/Cariology, Umeå University, 901 87, Umeå, Sweden
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- Tumkur Sitaram, Raviprakash, Senior Researcher, 1974- (författare)
- Umeå universitet,Institutionen för odontologi,Department of Odontology/Cariology, Umeå University, 901 87, Umeå, Sweden
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- Svensäter, Gunnel, 1954- (författare)
- Malmö universitet,Odontologiska fakulteten (OD)
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- Westerlund, Anna, 1970 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 3,Institute of Odontology, Section 3,Department of Orthodontics, Sahlgrenska Academy, University of Gothenburg, 413 90, Göteborg, Sweden
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- Strömberg, Nicklas (författare)
- Umeå universitet,Institutionen för odontologi,Department of Odontology/Cariology, Umeå University, 901 87, Umeå, Sweden
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: EBIOMEDICINE. - : Elsevier. - 2352-3964. ; 101
- Relaterad länk:
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background Lifestyle- and sucrose -dependent polymicrobial ecological shifts are a primary cause of caries in populations with high caries prevalence. In populations with low prevalence, PRH1, PRH2 susceptibility and resistance phenotypes may interact with the Streptococcus mutans adhesin cariogenicity phenotype to affect caries progression, but studies are lacking on how these factors affect the microbial profile of caries. Methods We analysed how the residency and infection profiles of S. mutans adhesin (SpaP A/B/C and Cnm/Cbm) phenotypes and commensal streptococci and lactobacilli influenced caries progression in a prospective case-referent sample of 452 Swedish adolescents with high (P4a), moderate (P6), and low (P1) caries PRH1, PRH2 phenotypes. Isolates of S. mutans from participants were analysed for adhesin expression and glycosylation and in vitro and in situ mechanisms related to caries activity. Findings Among adolescents with the resistant (P1) phenotype, infection with S. mutans high -virulence phenotypes was required for caries progression. In contrast, with highly (P4a) or moderately (P6) susceptible phenotypes, caries developed from a broader polymicrobial flora that included moderately cariogenic oral commensal streptococci and lactobacilli and S. mutans phenotypes. High virulence involved unstable residency and fluctuating SpaP ABC, B-1, or Cnm expression/glycosylation phenotypes, whereas low/moderate virulence involved SpaP A phenotypes with stable residency. Adhesin phenotypes did not display changes in individual host residency but were paired within individuals and geographic regions. Interpretation These results suggest that receptor PRH1, PRH2 susceptibility and resistance and S. mutans adhesin virulence phenotypes specify different microbial profiles in caries.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- Streptococcus mutans
- Host susceptibility
- PRH1/PRH2
- Caries
- Commensal pathogen
- Adhesion
- Adhesion
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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