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White matter volume...
White matter volume alterations in hair-pulling disorder (trichotillomania)
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- Uhlmann, Anne (author)
- Stellenbosch Univ, Dept Psychiat, MRC Unit Risk & Resilience Mental Disorders, POB 241, ZA-8000 Cape Town, South Africa; Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town, South Africa
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- Dias, Angelo (author)
- Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town, South Africa
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- Taljaard, Lian (author)
- Stellenbosch Univ, Dept Psychiat, MRC Unit Risk & Resilience Mental Disorders, POB 241, ZA-8000 Cape Town, South Africa
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- Stein, Dan J. (author)
- Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town, South Africa
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- Brooks, Samantha J. (author)
- Uppsala universitet,Schiöth: Funktionell farmakologi,Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town, South Africa
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- Lochner, Christine (author)
- Stellenbosch Univ, Dept Psychiat, MRC Unit Risk & Resilience Mental Disorders, POB 241, ZA-8000 Cape Town, South Africa
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(creator_code:org_t)
- 2019-08-02
- 2020
- English.
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In: Brain Imaging and Behavior. - : Springer Science and Business Media LLC. - 1931-7557 .- 1931-7565. ; 14:6, s. 2202-2209
- Related links:
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https://researchonli...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Trichotillomania (TTM) is a disorder characterized by repetitive hair-pulling resulting in hair loss. Key processes affected in TTM comprise affective, cognitive, and motor functions. Emerging evidence suggests that brain matter aberrations in fronto-striatal and fronto-limbic brain networks and the cerebellum may characterize the pathophysiology of TTM. The aim of the present voxel-based morphometry (VBM) study was to evaluate whole brain grey and white matter volume alteration in TTM and its correlation with hair-pulling severity. High-resolution magnetic resonance imaging (3 T) data were acquired from 29 TTM patients and 28 age-matched healthy controls (CTRLs). All TTM participants completed the Massachusetts General Hospital Hair-Pulling Scale (MGH-HPS) to assess illness/pulling severity. Using whole-brain VBM, between-group differences in regional brain volumes were measured. Additionally, within the TTM group, the relationship between MGH-HPS scores, illness duration and brain volumes were examined. All data were corrected for multiple comparisons using family-wise error (FWE) correction at p < 0.05. Patients with TTM showed larger white matter volumes in the parahippocampal gyrus and cerebellum compared to CTRLs. Estimated white matter volumes showed no significant association with illness duration or MGH-HPS total scores. No significant between-group differences were found for grey matter volumes. Our observations suggest regional alterations in cortico-limbic and cerebellar white matter in patients with TTM, which may underlie deficits in cognitive and affective processing. Such volumetric white matter changes may precipitate impaired cortico-cerebellar communication leading to a reduced ability to control hair pulling behavior.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Trichotillomania
- Compulsivity
- Impulsivity
- Neuroimaging
- Voxel-based morphometry
Publication and Content Type
- ref (subject category)
- art (subject category)
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