Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder

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Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder

de Zwarte, Sonja M. C. (author)

Brouwer, Rachel M. (author)

Agartz, Ingrid (author): Karolinska Institutet

Alda, Martin (author)

Alonso-Lana, Silvia (author)

Bearden, Carrie E. (author)

Bertolino, Alessandro (author)

Bonvino, Aurora (author)

Bramon, Elvira (author)

Buimer, Elizabeth E. L. (author)

Cahn, Wiepke (author)

Canales-Rodríguez, Erick J. (author)

Cannon, Dara M. (author)

Cannon, Tyrone D. (author)

Caseras, Xavier (author)

Castro-Fornieles, Josefina (author)

Chen, Qiang (author)

Chung, Yoonho (author)

De la Serna, Elena (author)

Del Mar Bonnin, Caterina (author)

Demro, Caroline (author)

Di Giorgio, Annabella (author)

Doucet, Gaelle E. (author)

Eker, Mehmet Cagdas (author)

Erk, Susanne (author)

Fatjó-Vilas, Mar (author)

Fears, Scott C. (author)

Foley, Sonya F. (author)

Frangou, Sophia (author)

Fullerton, Janice M. (author)

Glahn, David C. (author)

Goghari, Vina M. (author)

Goikolea, Jose M. (author)

Goldman, Aaron L. (author)

Gonul, Ali Saffet (author)

Gruber, Oliver (author)

Hajek, Tomas (author)

Hawkins, Emma L. (author)

Heinz, Andreas (author)

Hidiroglu Ongun, Ceren (author)

Hillegers, Manon H.J. (author)

Houenou, Josselin (author)

Hulshoff Pol, Hilleke E. (author)

Hultman, Christina M. (author)

Ingvar, Martin (author)

Johansson, Viktoria (author): Karolinska Institutet

Jönsson, Erik G. (author): Karolinska Institutet

Kane, Fergus (author)

Kempton, Matthew J. (author)

Koenis, Marinka M. G. (author)

Kopecek, Miloslav (author)

Krämer, Bernd (author)

Lawrie, Stephen M. (author)

Lenroot, Rhoshel K. (author)

Marcelis, Machteld (author)

Mattay, Venkata S. (author)

McDonald, Colm (author)

Meyer-Lindenberg, Andreas (author)

Michielse, Stijn (author)

Mitchell, Philip B. (author)

Moreno, Dolores (author)

Murray, Robin M. (author)

Mwangi, Benson (author)

Nabulsi, Leila (author)

Newport, Jason (author)

Olman, Cheryl A. (author)

van Os, Jim (author)

Overs, Bronwyn J. (author)

Ozerdem, Aysegul (author)

Pergola, Giulio (author)

Picchioni, Marco M. (author)

Piguet, Camille (author)

Pomarol-Clotet, Edith (author)

Radua, Joaquim (author): Karolinska Institutet

Ramsay, Ian S. (author)

Richter, Anja (author)

Roberts, Gloria (author)

Salvador, Raymond (author)

Saricicek Aydogan, Aybala (author)

Sarró, Salvador (author)

Schofield, Peter R. (author)

Simsek, Esma M. (author)

Simsek, Fatma (author)

Soares, Jair C. (author)

Sponheim, Scott R. (author)

Sugranyes, Gisela (author)

Toulopoulou, Timothea (author)

Tronchin, Giulia (author)

Vieta, Eduard (author)

Walter, Henrik (author)

Weinberger, Daniel R. (author)

Whalley, Heather C. (author)

Wu, Mon-Ju (author)

Yalin, Nefize (author)

Andreassen, Ole A. (author)

Ching, Christopher R. K. (author)

Thomopoulos, Sophia I. (author)

van Erp, Theo G. M. (author)

Jahanshad, Neda (author)

Thompson, Paul M. (author)

Kahn, René S. (author)

van Haren, Neeltje E. M. (author)

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(creator_code:org_t)

2020-10-07
2022
English.
In: Human Brain Mapping. - : John Wiley & Sons. - 1065-9471 .- 1097-0193. ; 43:1, s. 414-430

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); https://onlinelibrar...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs showed a pattern of widespread thinner cortex, while BD-FDRs had widespread larger cortical surface area. IQ was lower in SZ-FDRs (d = -0.42, p = 3 × 10-5 ), with weak evidence of IQ reductions among BD-FDRs (d = -0.23, p = .045). Both relative groups had similar educational attainment compared to controls. When adjusting for IQ or educational attainment, the group-effects on brain measures changed, albeit modestly. Changes were in the expected direction, with less pronounced brain abnormalities in SZ-FDRs and more pronounced effects in BD-FDRs. To conclude, SZ-FDRs and BD-FDRs show a differential pattern of structural brain abnormalities. In contrast, both had lower IQ scores and similar school achievements compared to controls. Given that brain differences between SZ-FDRs and BD-FDRs remain after adjusting for IQ or educational attainment, we suggest that differential brain developmental processes underlying predisposition for schizophrenia or bipolar disorder are likely independent of general cognitive impairment.

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By the author/editor: de Zwarte, Sonja ...; Brouwer, Rachel ...; Agartz, Ingrid; Alda, Martin; Alonso-Lana, Sil ...; Bearden, Carrie ...; show more...; Bertolino, Aless ...; Bonvino, Aurora; Bramon, Elvira; Buimer, Elizabet ...; Cahn, Wiepke; Canales-Rodrígue ...; Cannon, Dara M.; Cannon, Tyrone D ...; Caseras, Xavier; Castro-Fornieles ...; Chen, Qiang; Chung, Yoonho; De la Serna, Ele ...; Del Mar Bonnin, ...; Demro, Caroline; Di Giorgio, Anna ...; Doucet, Gaelle E ...; Eker, Mehmet Cag ...; Erk, Susanne; Fatjó-Vilas, Mar; Fears, Scott C.; Foley, Sonya F.; Frangou, Sophia; Fullerton, Janic ...; Glahn, David C.; Goghari, Vina M.; Goikolea, Jose M ...; Goldman, Aaron L ...; Gonul, Ali Saffe ...; Gruber, Oliver; Hajek, Tomas; Hawkins, Emma L.; Heinz, Andreas; Hidiroglu Ongun, ...; Hillegers, Manon ...; Houenou, Josseli ...; Hulshoff Pol, Hi ...; Hultman, Christi ...; Ingvar, Martin; Johansson, Vikto ...; Jönsson, Erik G.; Kane, Fergus; Kempton, Matthew ...; Koenis, Marinka ...; Kopecek, Milosla ...; Krämer, Bernd; Lawrie, Stephen ...; Lenroot, Rhoshel ...; Marcelis, Machte ...; Mattay, Venkata ...; McDonald, Colm; Meyer-Lindenberg ...; Michielse, Stijn; Mitchell, Philip ...; Moreno, Dolores; Murray, Robin M.; Mwangi, Benson; Nabulsi, Leila; Newport, Jason; Olman, Cheryl A.; van Os, Jim; Overs, Bronwyn J ...; Ozerdem, Aysegul; Pergola, Giulio; Picchioni, Marco ...; Piguet, Camille; Pomarol-Clotet, ...; Radua, Joaquim; Ramsay, Ian S.; Richter, Anja; Roberts, Gloria; Salvador, Raymon ...; Saricicek Aydoga ...; Sarró, Salvador; Schofield, Peter ...; Simsek, Esma M.; Simsek, Fatma; Soares, Jair C.; Sponheim, Scott ...; Sugranyes, Gisel ...; Toulopoulou, Tim ...; Tronchin, Giulia; Vieta, Eduard; Walter, Henrik; Weinberger, Dani ...; Whalley, Heather ...; Wu, Mon-Ju; Yalin, Nefize; Andreassen, Ole ...; Ching, Christoph ...; Thomopoulos, Sop ...; van Erp, Theo G. ...; Jahanshad, Neda; Thompson, Paul M ...; Kahn, René S.; van Haren, Neelt ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

Articles in the publication: Human Brain Mapp ...

By the university: Umeå University; Karolinska Institutet

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Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder

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