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Association of brai...
Association of brain network dynamics with plasma biomarkers in subjective memory complainers.
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Chiesa, Patrizia A (author)
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Houot, Marion (author)
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Vergallo, Andrea (author)
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Cavedo, Enrica (author)
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Lista, Simone (author)
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Potier, Marie Claude (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centre for Ageing and Health (Agecap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Vanmechelen, Eugeen (author)
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De Vos, Ann (author)
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Dubois, Bruno (author)
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Hampel, Harald (author)
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Neurobiology of aging. - : Elsevier BV. - 1558-1497 .- 0197-4580. ; 88, s. 83-90
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Using a single integrated analysis, we examined the relationship between brain networks and molecular pathways in a cohort of elderly individuals at risk for Alzheimer's disease. In 205 subjective memory complainers (124 females, mean age: 75.7 ± 3.4), individual functional connectome was computed for a total of 3081 functional connections (set A) and 6 core plasma biomarkers of Alzheimer's disease (set B) were assessed. Partial least squares correlation analysis identified one dimension of population covariation between the 2 sets (p < 0.006), which we named bioneural mode. Five core plasma biomarkers and 190 functional connections presented bootstrap ratios greater than the critical value |1.96|. T-tau protein showed a trend toward significance (bootstrap resampling= 1.64). The salience, the language, the visuospatial, and the default mode networks were the strongest significant networks. We detected a strong association between network dynamics and core pathophysiological blood biomarkers. Innovative composite biomarkers, such as the bioneural mode, are promising to provide outcomes and better inform drug development and clinical practice for neurodegenerative diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Chiesa, Patrizia ...
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Houot, Marion
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Vergallo, Andrea
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Cavedo, Enrica
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Lista, Simone
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Potier, Marie Cl ...
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show more...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Vanmechelen, Eug ...
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De Vos, Ann
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Dubois, Bruno
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Hampel, Harald
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neurobiology of ...
- By the university
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University of Gothenburg