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Sökning: onr:"swepub:oai:DiVA.org:umu-182156" > Prevalent diabetes ...

Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population : meta-analysis of individual participant data from cohorts of the CHANCES consortium

Amadou, Amina (författare)
International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France; Department of Prevention Cancer Environment, Centre Léon Bérard, Lyon, France
Freisling, Heinz (författare)
International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France
Jenab, Mazda (författare)
International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France
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Tsilidis, Konstantinos K. (författare)
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Trichopoulou, Antonia (författare)
Hellenic Health Foundation, Athens, Greece
Boffetta, Paolo (författare)
Stony Brook Cancer Center, Stony Brook University, NY, Stony Brook, United States; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
van Guelpen, Bethany (författare)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
Mokoroa, Olatz (författare)
Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastian, Spain
Wilsgaard, Tom (författare)
Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
Kee, Frank (författare)
Institute for Health Sciences Risk and Inequality, Centre for Public Health, Belfast, United Kingdom
Schöttker, Ben (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Ordóñez-Mena, José M. (författare)
Nuffield Department of Primary Care Health Sciences, Radcliffe Observatory Quarter, Woodstock Road, Oxford, United Kingdom; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
Männistö, Satu (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland
Söderberg, Stefan (författare)
Umeå universitet,Avdelningen för medicin
Vermeulen, Roel C. H. (författare)
Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands
Quirós, J. Ramón (författare)
Public Health Directorate, Asturias, Spain
Liao, Linda M. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
Sinha, Rashmi (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
Kuulasmaa, Kari (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland
Brenner, Hermann (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Romieu, Isabelle (författare)
International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France
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 (creator_code:org_t)
2021-03-26
2021
Engelska.
Ingår i: British Journal of Cancer. - : Nature Publishing Group. - 0007-0920 .- 1532-1827. ; 124:11, s. 1882-1890
Relaterad länk:
https://ora.ox.ac.uk...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: We investigated whether associations between prevalent diabetes and cancer risk are pertinent to older adults and whether associations differ across subgroups of age, body weight status or levels of physical activity.Methods: We harmonised data from seven prospective cohort studies of older individuals in Europe and the United States participating in the CHANCES consortium. Cox proportional hazard regression was used to estimate the associations of prevalent diabetes with cancer risk (all cancers combined, and for colorectum, prostate and breast). We calculated summary risk estimates across cohorts using pooled analysis and random-effects meta-analysis.Results: A total of 667,916 individuals were included with an overall median (P25–P75) age at recruitment of 62.3 (57–67) years. During a median follow-up time of 10.5 years, 114,404 total cancer cases were ascertained. Diabetes was not associated with the risk of all cancers combined (hazard ratio (HR) = 0.94; 95% confidence interval (CI): 0.86–1.04; I2 = 63.3%). Diabetes was positively associated with colorectal cancer risk in men (HR = 1.17; 95% CI: 1.08–1.26; I2 = 0%) and a similar HR in women (1.13; 95% CI: 0.82–1.56; I2 = 46%), but with a confidence interval including the null. Diabetes was inversely associated with prostate cancer risk (HR = 0.81; 95% CI: 0.77–0.85; I2 = 0%), but not with postmenopausal breast cancer (HR = 0.96; 95% CI: 0.89–1.03; I2 = 0%). In exploratory subgroup analyses, diabetes was inversely associated with prostate cancer risk only in men with overweight or obesity.Conclusions: Prevalent diabetes was positively associated with colorectal cancer risk and inversely associated with prostate cancer risk in older Europeans and Americans.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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