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Sökning: onr:"swepub:oai:DiVA.org:uu-421273" > Legumain in Acute C...

Legumain in Acute Coronary Syndromes : A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial

Gregersen, Ida (författare)
Oslo Univ Hosp, Res Inst Internal Med, Rikshosp, Sognsvannveien 72, N-0372 Oslo, Norway.;Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway.
Michelsen, Annika E. (författare)
Oslo Univ Hosp, Res Inst Internal Med, Rikshosp, Sognsvannveien 72, N-0372 Oslo, Norway.;Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway.
Lunde, Ngoc Nguyen (författare)
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Åkerblom, Axel, 1977- (författare)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden
Ghukasyan, Tatevik (författare)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
Skjelland, Mona (författare)
Oslo Univ Hosp, Rikshosp, Dept Neurol, Oslo, Norway.
Skagen, Karolina Ryeng (författare)
Oslo Univ Hosp, Rikshosp, Dept Neurol, Oslo, Norway.
Becker, Richard C. (författare)
Acad Hlth Ctr, Div Cardiovasc Hlth & Dis, Heart Lung & Vasc Inst, Cincinnati, OH USA.
Lindbäck, Johan (författare)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
Himmelmann, Anders (författare)
AstraZeneca Res & Dev, Gothenburg, Sweden.
Solberg, Rigmor (författare)
Univ Oslo, Sect Pharmacol & Pharmaceut Biosci, Dept Pharm, Oslo, Norway.
Johansen, Harald T. (författare)
Univ Oslo, Sect Pharmacol & Pharmaceut Biosci, Dept Pharm, Oslo, Norway.
James, Stefan, 1964- (författare)
Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.;Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden.
Siegbahn, Agneta, 1947- (författare)
Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden.
Storey, Robert F. (författare)
Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England.
Kontny, Frederic (författare)
Stavanger Univ Hosp, Dept Cardiol, Stavanger, Norway.;Drammen Heart Ctr, Drammen, Norway.
Aukrust, Pal (författare)
Oslo Univ Hosp, Res Inst Internal Med, Rikshosp, Sognsvannveien 72, N-0372 Oslo, Norway.;Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway.;Oslo Univ Hosp, Rikshosp, Sect Clin Immunol & Infect Dis, Oslo, Norway.;Arctic Univ Tromso, Fac Hlth Sci, KG Jebsen TREC, Tromso, Norway.
Ueland, Thor (författare)
Oslo Univ Hosp, Res Inst Internal Med, Rikshosp, Sognsvannveien 72, N-0372 Oslo, Norway.;Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway.;Arctic Univ Tromso, Fac Hlth Sci, KG Jebsen TREC, Tromso, Norway.
Wallentin, Lars, 1943- (författare)
Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
Halvorsen, Bente (författare)
Oslo Univ Hosp, Res Inst Internal Med, Rikshosp, Sognsvannveien 72, N-0372 Oslo, Norway.;Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway.
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Oslo Univ Hosp, Res Inst Internal Med, Rikshosp, Sognsvannveien 72, N-0372 Oslo, Norway;Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway. Uppsala kliniska forskningscentrum (UCR) (creator_code:org_t)
WILEY, 2020
2020
Engelska.
Ingår i: Journal of the American Heart Association. - : WILEY. - 2047-9980 .- 2047-9980. ; 9:17
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: The cysteine protease legumain is increased in patients with atherosclerosis, but its causal role in atherogenesis and cardiovascular disease is still unclear. The aim of the study was to investigate the association of legumain with clinical outcome in a large cohort of patients with acute coronary syndrome. METHODS AND RESULTS : Serum levels of legumain were analyzed in 4883 patients with acute coronary syndrome from a substudy of the PLATO (Platelet Inhibition and Patient Outcomes) trial. Levels were analyzed at admission and after 1 month follow-up. Associations between legumain and a composite of cardiovascular death, spontaneous myocardial infarction or stroke, and its individual components were assessed by multivariable Cox regression analyses. At baseline, a 50% increase in legumain level was associated with a hazard ratio (HR) of 1.13 (95% CI, 1.04-1.21),P=0.0018, for the primary composite end point, adjusted for randomized treatment. The association remained significant after adjustment for important clinical and demographic variables (HR, 1.10; 95% CI, 1.02-1.19;P=0.013) but not in the fully adjusted model. Legumain levels at 1 month were not associated with the composite end point but were negatively associated with stroke (HR, 0.62; 95% CI, 0.44-0.88;P=0.0069), including in the fully adjusted model (HR, 0.57; 95% CI, 0.37-0.88;P=0.0114). CONCLUSIONS: Baseline legumain was associated with the primary outcome in patients with acute coronary syndrome, but not in the fully adjusted model. The association between high levels of legumain at 1 month and decreased occurrence of stroke could be of interest from a mechanistic point of view, illustrating the potential dual role of legumain during atherogenesis and acute coronary syndrome. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00391872.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

acute coronary syndromes
ischemic stroke
legumain

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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