Sökning: WFRF:(Wallentin Lars C. 1943 )
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Locations and Mucos...
Locations and Mucosal Lesions Responsible for Major Gastrointestinal Bleeding in Patients on Warfarin or Dabigatran
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- Kolb, Jennifer M. (författare)
- Univ Colorado Hosp, Dept Gastroenterol & Hepatol, Denver, CO USA
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- Flack, Kathryn Friedman (författare)
- Hosp Univ Penn, Dept Internal Med, 3400 Spruce St, Philadelphia, PA 19104 USA
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- Chatterjee-Murphy, Prapti (författare)
- Icahn Sch Med Mt Sinai, Dept Internal Med, New York, NY 10029 USA
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- Desai, Jay (författare)
- Icahn Sch Med Mt Sinai, Dept Gastroenterol & Hepatol, New York, NY 10029 USA
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- Wallentin, Lars C., 1943- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Ezekowitz, Michael (författare)
- Thomas Jefferson Univ, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA
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- Connolly, Stuart (författare)
- McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada;Hamilton Hlth Sci, Hamilton, ON, Canada
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- Reilly, Paul (författare)
- Boehringer Ingelheim Pharmaceut, Ridgefield, CT USA
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- Brueckmann, Martina (författare)
- Boehringer Ingelheim Int GmbH, Ingelheim, Germany;Heidelberg Univ, Fac Med Mannheim, Mannheim, Germany
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- Ilgenfritz, John (författare)
- Ilgenfritz Consulting LLC, Conshohocken, PA USA
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- Aisenberg, James (författare)
- Icahn Sch Med Mt Sinai, Dept Gastroenterol & Hepatol, New York, NY 10029 USA
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(creator_code:org_t)
- 2018-03-27
- 2018
- Engelska.
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Ingår i: Digestive Diseases and Sciences. - : SPRINGER. - 0163-2116 .- 1573-2568. ; 63:7, s. 1878-1889
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Different oral anticoagulants may be associated with gastrointestinal bleeding (GIB) from different locations or mucosal lesions. We aimed to test this hypothesis. Two blinded gastroenterologists independently analyzed source documents from the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial of dabigatran 150 mg BID (D150), dabigatran 110 mg BID (D110) versus warfarin in non-valvular atrial fibrillation (NVAF). Major GIB events (total n = 546) and life-threatening GIB events (n = 258) were more common with D150 versus warfarin (RR 1.57 [1.28-1.92] and RR 1.62 [1.20-2.18], respectively) and similar for D110 compared to warfarin (RR 1.11 [0.89-1.38] and RR 1.16 [0.84-1.61], respectively). Fatal bleeding was similarly rare across treatment groups. Lower GI major bleeding and life-threatening bleeding were more common with D150 compared to warfarin (RR 2.23 [1.47, 3.38] and RR 2.64 [1.36, 5.13], respectively) and with D110 compared to warfarin (RR 1.78 [1.16, 2.75] and RR 2.00 [1.00, 4.00], respectively). MGIB from colonic angiodysplasia was increased with dabigatran versus warfarin (P < 0.01 for both dose comparisons). Subacute and chronic MGIB events were more common with D150 than with warfarin (RR 1.72 [1.06, 2.78] and RR 1.66 [1.12, 2.45], respectively), as were hematochezia or melena (RR 1.67 [1.18, 2.36] and RR 1.72 [1.20, 2.47], respectively). In a chronic NVAF population, D150 but not D110 is associated with increased major and life-threatening GI bleeding in comparison with warfarin. At both dabigatran doses, increased bleeding from the colorectum, in particular from angiodysplasia, is seen.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Gastrointestinal bleeding
- Gastrointestinal hemorrhage
- Life-threatening gastrointestinal bleeding
- Novel oral anticoagulants
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Kolb, Jennifer M ...
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Flack, Kathryn F ...
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Chatterjee-Murph ...
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Desai, Jay
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Wallentin, Lars ...
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Ezekowitz, Micha ...
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Connolly, Stuart
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Reilly, Paul
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Brueckmann, Mart ...
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Ilgenfritz, John
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Aisenberg, James
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