The PPAR-alpha gene in Alzheimer's disease: lack of replication of earlier association.

• Recently, a single nucleotide polymorphism (SNP, rs1800206) in the peroxisome proliferator-activated receptor alpha (PPAR-alpha) gene has been proposed to be associated with Alzheimer's disease (AD). To verify this finding, we analyzed the PPAR-alpha SNP in 461 patients with AD and 1395 controls. In subgroups, PPAR-alpha gene data could be investigated in relation to biochemical and neuropathological markers for AD. We found no significant differences in genotype or allele distributions between AD patients and controls. None of the PPAR-alpha gene variants influenced markers for AD.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Aged

Alzheimer Disease

genetics

metabolism

physiopathology

Amyloid beta-Protein

genetics

Brain

metabolism

physiopathology

Cohort Studies

DNA Mutational Analysis

Female

Gene Frequency

genetics

Genetic Markers

genetics

Genetic Predisposition to Disease

genetics

Genetic Screening

Genetic Variation

genetics

Genotype

Humans

Male

Middle Aged

PPAR alpha

analysis

genetics

metabolism

Polymorphism

Single Nucleotide

genetics

Predictive Value of Tests

Reproducibility of Results

tau Proteins

genetics

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)