Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

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Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

Vieira-Silva, S. (author): Katholieke Universiteit Leuven,European Molecular Biology Laboratory

Falony, G. (author): Katholieke Universiteit Leuven

Belda, E. (author)

Nielsen, T. (author): Köpenhamns universitet,University of Copenhagen

Aron-Wisnewsky, J. (author): Köpenhamns universitet,University of Copenhagen

Chakaroun, R. (author): Universität Leipzig,Leipzig University

Forslund, S. K. (author): Max Delbrueck Centrum Fuer Molekulare Medizin,The Max Delbrück Center for Molecular Medicine

Assmann, K. (author)

Valles-Colomer, M. (author): Katholieke Universiteit Leuven,Assistance publique – Hôpitaux de Paris (AP-HP)

Nguyen, T. T. D. (author): Katholieke Universiteit Leuven

Proost, S. (author): Katholieke Universiteit Leuven

Prifti, E. (author)

Tremaroli, Valentina, 1978 (author): Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine

Pons, N. (author): Université Paris-Saclay,University Paris-Saclay

Le Chatelier, E. (author): Université Paris-Saclay,University Paris-Saclay

Andreelli, F. (author)

Bastard, J. P. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Coelho, L. P. (author): European Molecular Biology Laboratory,Assistance publique – Hôpitaux de Paris (AP-HP)

Galleron, N. (author): Université Paris-Saclay,University Paris-Saclay

Hansen, T. H. (author): Köpenhamns universitet,University of Copenhagen

Hulot, J. S. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Lewinter, C. (author): Köpenhamns universitet,University of Copenhagen

Pedersen, H. K. (author): Köpenhamns universitet,University of Copenhagen

Quinquis, B. (author): Université Paris-Saclay,University Paris-Saclay

Rouault, C. (author)

Roume, H. (author): Université Paris-Saclay,University Paris-Saclay

Salem, J. E. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Søndertoft, N. B. (author): Köpenhamns universitet,University of Copenhagen

Touch, S. (author)

Alves, R. (author): European Molecular Biology Laboratory

Amouyal, C. (author)

Galijatovic, E. A. A. (author): Köpenhamns universitet,University of Copenhagen

Barthelemy, O. (author): Assistance publique – Hôpitaux de Paris (AP-HP),Köpenhamns universitet,University of Copenhagen

Batisse, J. P. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Berland, M. (author): Université Paris-Saclay,University Paris-Saclay

Bittar, R. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Blottière, H. (author): Université Paris-Saclay,University Paris-Saclay

Bosquet, F. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Boubrit, R. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Bourron, O. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Camus, M. (author): Université Paris-Saclay,University Paris-Saclay

Cassuto, D. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Ciangura, C. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Collet, J. P. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Dao, M. C. (author)

Debedat, J. (author)

Djebbar, M. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Doré, A. (author): Université Paris-Saclay,University Paris-Saclay

Engelbrechtsen, L. (author): Köpenhamns universitet,University of Copenhagen

Fellahi, S. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Fromentin, S. (author): Université Paris-Saclay,University Paris-Saclay

Giral, P. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Graine, M. (author)

Hartemann, A. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Hartmann, B. (author): Köpenhamns universitet,University of Copenhagen

Helft, G. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Hercberg, S. (author)

Hornbak, M. (author): Köpenhamns universitet,University of Copenhagen

Isnard, R. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Jaqueminet, S. (author)

Jørgensen, N. R. (author): Köpenhamns universitet,University of Copenhagen

Julienne, H. (author): Université Paris-Saclay,University Paris-Saclay

Justesen, J. (author)

Kammer, J. (author): Universität Leipzig,Leipzig University

Kerneis, M. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Khemis, J. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Krarup, N. (author): Köpenhamns universitet,University of Copenhagen

Kuhn, M. (author): European Molecular Biology Laboratory

Lampuré, A. (author)

Lejard, V. (author): Université Paris-Saclay,University Paris-Saclay

Levenez, F. (author): Université Paris-Saclay,University Paris-Saclay

Lucas-Martini, L. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Massey, R. (author): Université Paris-Saclay,University Paris-Saclay

Maziers, N. (author): Université Paris-Saclay,University Paris-Saclay

Medina-Stamminger, J. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Moitinho-Silva, L. (author): European Molecular Biology Laboratory

Montalescot, G. (author)

Moutel, S. (author): Assistance publique – Hôpitaux de Paris (AP-HP),Universität Leipzig,Leipzig University

Le Pavin, L. P. (author): Université Paris-Saclay,University Paris-Saclay

Poitou-Bernert, C. (author)

Pousset, F. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Pouzoulet, L. (author)

Schmidt, S. (author)

Silvain, J. (author)

Svendstrup, M. (author): Köpenhamns universitet,University of Copenhagen

Swartz, T. (author)

Vanduyvenboden, T. (author): Université Paris-Saclay,University Paris-Saclay

Vatier, C. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Verger, E. (author)

Walther, S. (author): Universität Leipzig,Leipzig University

Dumas, M. E. (author): Imperial College of Science, Technology and Medicine

Ehrlich, S. D. (author): Université Paris-Saclay,University Paris-Saclay

Galan, P. (author)

Gøtze, J. P. (author): Köpenhamns universitet,University of Copenhagen

Hansen, T. (author)

Holst, J. J. (author): Köpenhamns universitet,University of Copenhagen

Køber, L. (author): Köpenhamns universitet,University of Copenhagen

Letunic, I. (author): Biobyte Solutions GmbH

Nielsen, Jens B, 1962 (author): Chalmers tekniska högskola,Chalmers University of Technology

Oppert, J. M. (author): Assistance publique – Hôpitaux de Paris (AP-HP)

Stumvoll, M. (author)

Vestergaard, H. (author): Köpenhamns universitet,University of Copenhagen

Zucker, J. D. (author)

Bork, P. (author): European Molecular Biology Laboratory

Pedersen, O. (author)

Bäckhed, Fredrik, 1973 (author): Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,Köpenhamns universitet,University of Copenhagen

Clément, K. (author)

Raes, J. (author): Katholieke Universiteit Leuven

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(creator_code:org_t)

2020-05-06
2020
English.
In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 581:7808, s. 310-315

Related links:: https://lirias.kuleu...; show more...; https://gup.ub.gu.se...; https://doi.org/10.1...; https://research.cha...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Microbiome community typing analyses have recently identified the Bacteroides2 (Bact2) enterotype, an intestinal microbiota configuration that is associated with systemic inflammation and has a high prevalence in loose stools in humans1,2. Bact2 is characterized by a high proportion of Bacteroides, a low proportion of Faecalibacterium and low microbial cell densities1,2, and its prevalence varies from 13% in a general population cohort to as high as 78% in patients with inflammatory bowel disease2. Reported changes in stool consistency3 and inflammation status4 during the progression towards obesity and metabolic comorbidities led us to propose that these developments might similarly correlate with an increased prevalence of the potentially dysbiotic Bact2 enterotype. Here, by exploring obesity-associated microbiota alterations in the quantitative faecal metagenomes of the cross-sectional MetaCardis Body Mass Index Spectrum cohort (n = 888), we identify statin therapy as a key covariate of microbiome diversification. By focusing on a subcohort of participants that are not medicated with statins, we find that the prevalence of Bact2 correlates with body mass index, increasing from 3.90% in lean or overweight participants to 17.73% in obese participants. Systemic inflammation levels in Bact2-enterotyped individuals are higher than predicted on the basis of their obesity status, indicative of Bact2 as a dysbiotic microbiome constellation. We also observe that obesity-associated microbiota dysbiosis is negatively associated with statin treatment, resulting in a lower Bact2 prevalence of 5.88% in statin-medicated obese participants. This finding is validated in both the accompanying MetaCardis cardiovascular disease dataset (n = 282) and the independent Flemish Gut Flora Project population cohort (n = 2,345). The potential benefits of statins in this context will require further evaluation in a prospective clinical trial to ascertain whether the effect is reproducible in a randomized population and before considering their application as microbiota-modulating therapeutics. © 2020, The Author(s), under exclusive licence to Springer Nature Limited.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)

Keyword

hydroxymethylglutaryl coenzyme A reductase inhibitor
bacterium
cell
digestive system
disease prevalence
microbial community
Article
bacterial count
bacterium identification
Bacteroides
body mass
cell density
comorbidity
correlation analysis
dysbiosis
Faecalibacterium
feces analysis
human
hypercholesterolemia
inflammation
inflammatory bowel disease
intestine flora
metabolic disorder
metagenome
nonhuman
obesity
prediction
prevalence
priority journal
quantitative analysis
species diversity

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor: Vieira-Silva, S.; Falony, G.; Belda, E.; Nielsen, T.; Aron-Wisnewsky, ...; Chakaroun, R.; show more...; Forslund, S. K.; Assmann, K.; Valles-Colomer, ...; Nguyen, T. T. D.; Proost, S.; Prifti, E.; Tremaroli, Valen ...; Pons, N.; Le Chatelier, E.; Andreelli, F.; Bastard, J. P.; Coelho, L. P.; Galleron, N.; Hansen, T. H.; Hulot, J. S.; Lewinter, C.; Pedersen, H. K.; Quinquis, B.; Rouault, C.; Roume, H.; Salem, J. E.; Søndertoft, N. B ...; Touch, S.; Alves, R.; Amouyal, C.; Galijatovic, E. ...; Barthelemy, O.; Batisse, J. P.; Berland, M.; Bittar, R.; Blottière, H.; Bosquet, F.; Boubrit, R.; Bourron, O.; Camus, M.; Cassuto, D.; Ciangura, C.; Collet, J. P.; Dao, M. C.; Debedat, J.; Djebbar, M.; Doré, A.; Engelbrechtsen, ...; Fellahi, S.; Fromentin, S.; Giral, P.; Graine, M.; Hartemann, A.; Hartmann, B.; Helft, G.; Hercberg, S.; Hornbak, M.; Isnard, R.; Jaqueminet, S.; Jørgensen, N. R.; Julienne, H.; Justesen, J.; Kammer, J.; Kerneis, M.; Khemis, J.; Krarup, N.; Kuhn, M.; Lampuré, A.; Lejard, V.; Levenez, F.; Lucas-Martini, L ...; Massey, R.; Maziers, N.; Medina-Stamminge ...; Moitinho-Silva, ...; Montalescot, G.; Moutel, S.; Le Pavin, L. P.; Poitou-Bernert, ...; Pousset, F.; Pouzoulet, L.; Schmidt, S.; Silvain, J.; Svendstrup, M.; Swartz, T.; Vanduyvenboden, ...; Vatier, C.; Verger, E.; Walther, S.; Dumas, M. E.; Ehrlich, S. D.; Galan, P.; Gøtze, J. P.; Hansen, T.; Holst, J. J.; Køber, L.; Letunic, I.; Nielsen, Jens B, ...; Oppert, J. M.; Stumvoll, M.; Vestergaard, H.; Zucker, J. D.; Bork, P.; Pedersen, O.; Bäckhed, Fredrik ...; Clément, K.; Raes, J.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Bioinformatics a ...

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