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Sökning: onr:"swepub:oai:DiVA.org:oru-64711" > RBBP6 increases rad...

RBBP6 increases radioresistance and serves as a therapeutic target for preoperative radiotherapy in colorectal cancer

Xiao, Chao (författare)
Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China
Wang, Yupeng (författare)
Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China
Zheng, Miao (författare)
Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China
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Chen, Jian (författare)
Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China
Song, Guohe (författare)
Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China
Zhou, Zhijie (författare)
Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China
Zhou, Chongzhi (författare)
Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China
Sun, Xing (författare)
Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China
Zhong, Lin (författare)
Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China
Ding, Erxun (författare)
Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China
Zhang, Yi (författare)
Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China
Yang, Liu (författare)
Department of Obstetrics and Gynecology, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China
Wu, Gang (författare)
Department of General Surgery, Henan Provincial People's Hospital People's Hospital, Zhengzhou University, Zhengzhou, People's Republic of China
Xu, Shifeng (författare)
Department of General Surgery, Shandong Provincial Hospital Affiliated, Shandong University, Jinan, People's Republic of China
Zhang, Hong, 1957- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper
Wang, Xiaoliang (författare)
Department of General Surgery, Shanghai General Hospital School of Medicine, Jiao Tong University, Shanghai, People's Republic of China
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 (creator_code:org_t)
2018-03-10
2018
Engelska.
Ingår i: Cancer Science. - : Blackwell Publishing. - 1347-9032 .- 1349-7006. ; 109:4, s. 1075-1087
Relaterad länk:
https://doi.org/10.1...
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https://onlinelibrar...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Radiotherapy (RT) can be used as preoperative treatment to downstage initially unresectable locally rectal carcinoma, but the radioresistance and recurrence remain significant problems. Retinoblastoma binding protein 6 (RBBP6) has been implicated in the regulation of cell cycle, apoptosis and chemoresistance both in vitro and in vivo. This study investigated whether the inhibition of RBBP6 expression would improve radiosensitivity in human colorectal cancer cells. After SW620 and HT29 cells were exposed to radiation, the levels of RBBP6 mRNA and protein increased over time in both two cells. Moreover, a significant reduction in clonogenic survival and a decrease in cell viability in parallel with an obvious increase in cell apoptosis were demonstrated in irradiated RBBP6-knockdown cells. Besides, transfection with RBBP6 shRNA improved levels of G2-M phase arrest which blocked the cells in a more radiosensitive period of the cell cycle. These observations indicated that cell cycle and apoptosis mechanisms may be connected with tumor cell survival following radiotherapy. In vivo, tumor growth rate of nude mice in RBBP6-knockdown group was significantly slower than that in other groups. These results indicated that RBBP6 overexpression could resist colorectal cancer cells against radiation by regulating cell cycle and apoptosis pathways, and inhibition of RBBP6 could enhance radiosensitivity of human colorectal cancer.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Apoptosis
Cell cycle
Preoperative radiotherapy
RBBP6
Rectal cancer

Publikations- och innehållstyp

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