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Retrospective, Mult...
Retrospective, Multicenter Analysis Comparing Conventional with Oncoplastic Breast Conserving Surgery : Oncological and Surgical Outcomes in Women with High-Risk Breast Cancer from the OPBC-01/iTOP2 Study
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- Fitzal, Florian (author)
- Med Univ Vienna, Dept Gen Surg, Vienna, Austria.;Med Univ Vienna, Breast Hlth Ctr, Vienna, Austria
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- Bolliger, Michael (author)
- Med Univ Vienna, Dept Gen Surg, Vienna, Austria.;Med Univ Vienna, Breast Hlth Ctr, Vienna, Austria
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- Dunkler, Daniela (author)
- Med Univ Vienna, Ctr Med Stat Informat & Intelligent Syst, Vienna, Austria
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- Geroldinger, Angelika (author)
- Med Univ Vienna, Ctr Med Stat Informat & Intelligent Syst, Vienna, Austria
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- Gambone, Luca (author)
- Med Univ Vienna, Dept Gen Surg, Vienna, Austria.;Med Univ Vienna, Breast Hlth Ctr, Vienna, Austria
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- Heil, Joerg (author)
- Heidelberg Univ Hosp, Breast Ctr, Dept Obstet & Gynecol, Heidelberg, Germany
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- Riedel, Fabian (author)
- Heidelberg Univ Hosp, Breast Ctr, Dept Obstet & Gynecol, Heidelberg, Germany
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- de Boniface, Jana (author)
- Karolinska Institutet
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- André, Camilla (author)
- Uppsala universitet,Endokrinkirurgi,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
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- Matrai, Zoltan (author)
- Natl Inst Oncol, Dept Breast & Sarcoma Surg, Budapest, Hungary
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- Pukancsik, David (author)
- Natl Inst Oncol, Dept Breast & Sarcoma Surg, Budapest, Hungary
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- Paulinelli, Regis R. (author)
- Univ Fed Goias, Araujo Jorge Hosp, Goias Anticanc Assoc, Goiania, Go, Brazil.
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- Ostapenko, Valerijus (author)
- Natl Canc Inst Vilnius Lithuania, Vilnius, Lithuania.;Univ Vilnius, Fac Med, Vilnius, Lithuania
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- Burneckis, Arvydas (author)
- Natl Canc Inst Vilnius Lithuania, Vilnius, Lithuania.;Univ Vilnius, Fac Med, Vilnius, Lithuania
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- Ostapenko, Andrej (author)
- Natl Canc Inst Vilnius Lithuania, Vilnius, Lithuania.;Univ Vilnius, Fac Med, Vilnius, Lithuania
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- Ostapenko, Edvin (author)
- Natl Canc Inst Vilnius Lithuania, Vilnius, Lithuania.;Univ Vilnius, Fac Med, Vilnius, Lithuania
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- Meani, Francesco (author)
- Ctr Senol Svizzera Italiana CSSI, Lugano, Switzerland.;Ente Osped Cantonale EOC, Dept Obstet & Gynecol, Lugano, Switzerland
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- Harder, Yves (author)
- Ctr Senol Svizzera Italiana CSSI, Lugano, Switzerland.;Ente Osped Cantonale EOC, Dept Plast Reconstruct & Aesthet Surg, Lugano, Switzerland.;Univ Svizzera Italiana USI, Fac Biomed Sci, Lugano, Switzerland
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- Bonollo, Marta (author)
- Ctr Senol Svizzera Italiana CSSI, Lugano, Switzerland.;Ente Osped Cantonale EOC, Dept Obstet & Gynecol, Lugano, Switzerland
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- Alberti, Andrea S. M. (author)
- Ctr Senol Svizzera Italiana CSSI, Lugano, Switzerland.;Ente Osped Cantonale EOC, Dept Plast Reconstruct & Aesthet Surg, Lugano, Switzerland.;Univ Svizzera Italiana USI, Fac Biomed Sci, Lugano, Switzerland
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- Tausch, Christoph (author)
- Breast Ctr, Zurich, Switzerland
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- Papassotiropoulos, Baerbel (author)
- Breast Ctr, Zurich, Switzerland
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- Helfgott, Ruth (author)
- Ordensklinikum Linz Sisters Charity, Dept Surg, Linz, Austria
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- Heck, Dietmar (author)
- Ordensklinikum Linz Sisters Charity, Dept Surg, Linz, Austria
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- Fehrer, Hans-Joerg (author)
- Ordensklinikum Linz Sisters Charity, Dept Surg, Linz, Austria
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- Acko, Markus (author)
- Ordensklinikum Linz Sisters Charity, Dept Surg, Linz, Austria
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- Schrenk, Peter (author)
- Med Univ Graz, Dept Obstet & Gynecol, Graz, Austria
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- Trapp, Elisabeth K. (author)
- Med Univ Graz, Dept Obstet & Gynecol, Graz, Austria
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- Gunda, Pristauz-Telsnigg (author)
- Med Univ Graz, Dept Obstet & Gynecol, Graz, Austria
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- Clara, Paliczek (author)
- Med Univ Graz, Dept Obstet & Gynecol, Graz, Austria
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- Montagna, Giacomo (author)
- Univ Hosp Basel, Breast Ctr, Basel, Switzerland.;Mem Sloan Kettering Canc Ctr, Dept Surg, Breast Serv, New York, NY 10021 USA
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- Ritter, Mathilde (author)
- Univ Hosp Basel, Breast Ctr, Basel, Switzerland
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- Blohmer, Jens-Uwe (author)
- Charite, Dept Gynecol, Campus Charite Mitte, Berlin, Germany.;Charite, Breast Ctr, Campus Charite Mitte, Berlin, Germany
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- Steffen, Sander (author)
- Univ Med Ctr Berlin, Charite Comprehens Canc Ctr CCCC, Clin Canc Registry, Berlin, Germany
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- Romics, Laszlo (author)
- NHS Greater Glasgow & Clyde, New Victoria Hosp, Glasgow, Lanark, Scotland
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- Morrow, Elizabeth (author)
- Univ Glasgow, Dept Acad Surg, Glasgow, Lanark, Scotland
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- Lorenz, Katharina (author)
- Cantonal Hosp Frauenfeld, Dept Gynecol & Obstet, Frauenfeld, Switzerland
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- Fehr, Mathias (author)
- Cantonal Hosp Frauenfeld, Dept Gynecol & Obstet, Frauenfeld, Switzerland
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- Weber, Walter Paul (author)
- Univ Hosp Basel, Breast Ctr, Basel, Switzerland.;Univ Basel, Basel, Switzerland
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Med Univ Vienna, Dept Gen Surg, Vienna, Austria;Med Univ Vienna, Breast Hlth Ctr, Vienna, Austria Med Univ Vienna, Ctr Med Stat Informat & Intelligent Syst, Vienna, Austria (creator_code:org_t)
- 2021-10-13
- 2022
- English.
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In: Annals of Surgical Oncology. - : Springer Nature. - 1068-9265 .- 1534-4681. ; 29:2, s. 1061-1070
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Abstract
Subject headings
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- Introduction Recent data suggest that margins >= 2 mm after breast-conserving surgery may improve local control in invasive breast cancer (BC). By allowing large resection volumes, oncoplastic breast-conserving surgery (OBCII; Clough level II/Tubingen 5-6) may achieve better local control than conventional breast conserving surgery (BCS; Tubingen 1-2) or oncoplastic breast conservation with low resection volumes (OBCI; Clough level I/Tubingen 3-4). Methods Data from consecutive high-risk BC patients treated in 15 centers from the Oncoplastic Breast Consortium (OPBC) network, between January 2010 and December 2013, were retrospectively reviewed. Results A total of 3,177 women were included, 30% of whom were treated with OBC (OBCI n = 663; OBCII n = 297). The BCS/OBCI group had significantly smaller tumors and smaller resection margins compared with OBCII (pT1: 50% vs. 37%, p = 0.002; proportion with margin <1 mm: 17% vs. 6%, p < 0.001). There were significantly more re-excisions due to R1 ("ink on tumor") in the BCS/OBCI compared with the OBCII group (11% vs. 7%, p = 0.049). Univariate and multivariable regression analysis adjusted for tumor biology, tumor size, radiotherapy, and systemic treatment demonstrated no differences in local, regional, or distant recurrence-free or overall survival between the two groups. Conclusions Large resection volumes in oncoplastic surgery increases the distance from cancer cells to the margin of the specimen and reduces reexcision rates significantly. With OBCII larger tumors are resected with similar local, regional and distant recurrence-free as well as overall survival rates as BCS/OBCI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Fitzal, Florian
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Bolliger, Michae ...
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Dunkler, Daniela
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Geroldinger, Ang ...
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Gambone, Luca
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Heil, Joerg
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show more...
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Riedel, Fabian
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de Boniface, Jan ...
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André, Camilla
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Matrai, Zoltan
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Pukancsik, David
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Paulinelli, Regi ...
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Ostapenko, Valer ...
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Burneckis, Arvyd ...
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Ostapenko, Andre ...
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Ostapenko, Edvin
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Meani, Francesco
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Harder, Yves
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Bonollo, Marta
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Alberti, Andrea ...
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Tausch, Christop ...
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Papassotiropoulo ...
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Helfgott, Ruth
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Heck, Dietmar
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Fehrer, Hans-Joe ...
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Acko, Markus
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Schrenk, Peter
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Trapp, Elisabeth ...
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Gunda, Pristauz- ...
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Clara, Paliczek
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Montagna, Giacom ...
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Ritter, Mathilde
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Blohmer, Jens-Uw ...
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Steffen, Sander
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Romics, Laszlo
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Morrow, Elizabet ...
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Lorenz, Katharin ...
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Fehr, Mathias
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Weber, Walter Pa ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Annals of Surgic ...
- By the university
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Uppsala University
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Karolinska Institutet