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Sökning: onr:"swepub:oai:DiVA.org:umu-214066" > Phenotyping asthma ...

Phenotyping asthma with airflow obstruction in middle-aged and older adults : a CADSET clinical research collaboration

Bertels, Xander (författare)
Department of Bioanalysis, Ghent University, Gent, Belgium; Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands
Edris, Ahmed (författare)
Department of Bioanalysis, Ghent University, Gent, Belgium; Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands
Garcia-Aymerich, Judith (författare)
Non-Communicable Diseases and Environment Programme, ISGlobal, Barcelona, Spain; Centro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain
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Faner, Rosa (författare)
Centro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain; Department of Biomedical Sciences, University of Barcelona, Barcelona, Spain
Meteran, Howraman (författare)
Department of Respiratory Medicine, Copenhagen University Hospital-Amager and Hvidovre, Denmark; Environment, Occupation and Health, Danish Ramazzini Centre, Department of Public Health, Aarhus University, Aarhus, Denmark
Sigsgaard, Torben (författare)
Environment, Occupation and Health, Danish Ramazzini Centre, Department of Public Health, Aarhus University, Aarhus, Denmark
Alter, Peter (författare)
Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg, Marburg, Germany
Vogelmeier, Claus (författare)
Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg, Marburg, Germany; Department of Respiratory and Critical Care Medicine and Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Otto Wagner Hospital, Vienna, Austria
Olvera, Nuria (författare)
Centro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain
Kermani, Nazanin Zounemat (författare)
National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom
Agusti, Alvar (författare)
Centro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain; Department of Medicine, University of Barcelona, Barcelona, Spain; Respiratory Institute, Hospital Clinic de Barcelona, Barcelona, Spain
Donaldson, Gavin C. (författare)
National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom
Wedzicha, Jadwiga A. (författare)
National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom
Brusselle, Guy G. (författare)
Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands; Department of Respiratory Medicine, Erasmus MC, Rotterdam, Netherlands; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
Backman, Helena (författare)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin
Rönmark, Eva (författare)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin
Lindberg, Anne (författare)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin
Vonk, Judith M. (författare)
Department of Epidemiology, University Medical Centre Groningen, Groningen, Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Centre Groningen, Groningen, Netherlands
Chung, Kian Fan (författare)
National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom
Adcock, Ian M. (författare)
National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom
van den Berge, Maarten (författare)
Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Centre Groningen, Groningen, Netherlands; Department of Pulmonology, University Medical Centre Groningen, Groningen, Netherlands
Lahousse, Lies (författare)
Department of Bioanalysis, Ghent University, Gent, Belgium; Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands
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 (creator_code:org_t)
BMJ Publishing Group Ltd, 2023
2023
Engelska.
Ingår i: BMJ open respiratory research. - : BMJ Publishing Group Ltd. - 2052-4439. ; 10:1
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: The prevalence and clinical profile of asthma with airflow obstruction (AO) remain uncertain. We aimed to phenotype AO in population- and clinic-based cohorts.METHODS: This cross-sectional multicohort study included adults ≥50 years from nine CADSET cohorts with spirometry data (N=69 789). AO was defined as ever diagnosed asthma with pre-BD or post-BD FEV1/FVC <0.7 in population-based and clinic-based cohorts, respectively. Clinical characteristics and comorbidities of AO were compared with asthma without airflow obstruction (asthma-only) and chronic obstructive pulmonary disease (COPD) without asthma history (COPD-only). ORs for comorbidities adjusted for age, sex, smoking status and body mass index (BMI) were meta-analysed using a random effects model.RESULTS: The prevalence of AO was 2.1% (95% CI 2.0% to 2.2%) in population-based, 21.1% (95% CI 18.6% to 23.8%) in asthma-based and 16.9% (95% CI 15.8% to 17.9%) in COPD-based cohorts. AO patients had more often clinically relevant dyspnoea (modified Medical Research Council score ≥2) than asthma-only (+14.4 and +14.7 percentage points) and COPD-only (+24.0 and +5.0 percentage points) in population-based and clinic-based cohorts, respectively. AO patients had more often elevated blood eosinophil counts (>300 cells/µL), although only significant in population-based cohorts. Compared with asthma-only, AO patients were more often men, current smokers, with a lower BMI, had less often obesity and had more often chronic bronchitis. Compared with COPD-only, AO patients were younger, less often current smokers and had less pack-years. In the general population, AO patients had a higher risk of coronary artery disease than asthma-only and COPD-only (OR=2.09 (95% CI 1.26 to 3.47) and OR=1.89 (95% CI 1.10 to 3.24), respectively) and of depression (OR=1.41 (95% CI 1.19 to 1.67)), osteoporosis (OR=2.30 (95% CI 1.43 to 3.72)) and gastro-oesophageal reflux disease (OR=1.68 (95% CI 1.06 to 2.68)) than COPD-only, independent of age, sex, smoking status and BMI.CONCLUSIONS: AO is a relatively prevalent respiratory phenotype associated with more dyspnoea and a higher risk of coronary artery disease and elevated blood eosinophil counts in the general population compared with both asthma-only and COPD-only.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Nyckelord

Asthma
Asthma Epidemiology
Clinical Epidemiology
COPD epidemiology
Pulmonary Disease
Chronic Obstructive

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