SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:umu-205934"
 

Sökning: onr:"swepub:oai:DiVA.org:umu-205934" > Genome-wide interac...

Genome-wide interaction study with smoking for colorectal cancer risk identifies novel genetic loci related to tumor suppression, inflammation, and immune response

Carreras-Torres, Robert (författare)
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), Salt, Girona, Spain
Kim, Andre E. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Lin, Yi (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
visa fler...
Díez-Obrero, Virginia (författare)
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Bien, Stephanie A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Qu, Conghui (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Wang, Jun (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Dimou, Niki (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Aglago, Elom K. (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Albanes, Demetrius (författare)
Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
Arndt, Volker (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Baurley, James W. (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Berndt, Sonja I. (författare)
Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
Bézieau, Stéphane (författare)
Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU) Nantes, Nantes, France
Bishop, D Timothy (författare)
Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
Bouras, Emmanouil (författare)
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Brenner, Hermann (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Budiarto, Arif (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Campbell, Peter T. (författare)
Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia
Casey, Graham (författare)
Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States
Chan, Andrew T. (författare)
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
Chang-Claude, Jenny (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Chen, Xuechen (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Conti, David V. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Dampier, Christopher H. (författare)
Department of General Surgery, University of Virginia School of Medicine, VA, Charlottesville, United States
Devall, Matthew A M (författare)
Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States
Drew, David A. (författare)
Clinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
Figueiredo, Jane C. (författare)
Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
Gallinger, Steven (författare)
Lunenfeld Tanenbaum Research Institute, University of Toronto, Mount Sinai Hospital, ON, Toronto, Canada
Giles, Graham G. (författare)
Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
Gruber, Stephen B. (författare)
Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, California
Gsur, Andrea (författare)
Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria
Gunter, Marc J. (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Harrison, Tabitha A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Hidaka, Akihisa (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Hoffmeister, Michael (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Huyghe, Jeroen R. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Jenkins, Mark A. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia
Jordahl, Kristina M. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Kawaguchi, Eric (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Keku, Temitope O. (författare)
Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, United States
Kundaje, Anshul (författare)
Department of Genetics, Department of Computer Science, Stanford University, CA, Stanford, United States
Le Marchand, Loic (författare)
University of Hawaii Cancer Center, HI, Honolulu, United States
Lewinger, Juan Pablo (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Li, Li (författare)
Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
Mahesworo, Bharuno (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Morrison, John L. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Murphy, Neil (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Nan, Hongmei (författare)
Department of Epidemiology, Richard M. Fairbanks School of Public Health, IN, Indianapolis, United States
Nassir, Rami (författare)
Department of Pathology, School of Medicine, Umm Al-Qura'a University, Saudi Arabia
Newcomb, Polly A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Obón-Santacana, Mireia (författare)
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Ogino, Shuji (författare)
Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Oncologic Pathology, Dana-Farber Cancer Institute, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Broad Institute of MIT and Harvard, MA, Cambridge, United States
Ose, Jennifer (författare)
Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
Pai, Rish K. (författare)
Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, AZ, Scottsdale, United States
Palmer, Julie R. (författare)
Slone Epidemiology Center at Boston University, MA, Boston, United States
Papadimitriou, Nikos (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Pardamean, Bens (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Peoples, Anita R. (författare)
Huntsman Cancer Institute, UT, Salt Lake City, United States
Pharoah, Paul D P (författare)
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Platz, Elizabeth A. (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, Liberia
Rennert, Gad (författare)
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel
Ruiz-Narvaez, Edward (författare)
Department of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States
Sakoda, Lori C. (författare)
Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
Scacheri, Peter C. (författare)
Department of Genetics and Genome Sciences, Case Western Reserve University, OH, Cleveland, United States
Schmit, Stephanie L. (författare)
Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, OH, Cleveland, United States
Schoen, Robert E. (författare)
Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
Shcherbina, Anna (författare)
Biomedical Informatics Program, Dept. of Biomedical Data Sciences, Stanford University, CA, Stanford, United States
Slattery, Martha L. (författare)
Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
Stern, Mariana C. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Su, Yu-Ru (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Tangen, Catherine M. (författare)
SWOG Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Thomas, Duncan C. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Tian, Yu (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, China
Tsilidis, Konstantinos K. (författare)
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Ulrich, Cornelia M. (författare)
Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
van Duijnhoven, Fränzel J B (författare)
Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands
van Guelpen, Bethany (författare)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
Visvanathan, Kala (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, Liberia
Vodicka, Pavel (författare)
Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, and Biomedical Center, Medical Faculty, Pilsen, Czech Republic
Cenggoro, Tjeng Wawan (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Weinstein, Stephanie J. (författare)
Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
White, Emily (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Wolk, Alicja (författare)
Karolinska Institutet
Woods, Michael O. (författare)
Memorial University of Newfoundland, Discipline of Genetics, St. John's, Canada
Hsu, Li (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Peters, Ulrike (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States
Moreno, Victor (författare)
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
Gauderman, W. James (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
visa färre...
 (creator_code:org_t)
American association for cancer research, 2023
2023
Engelska.
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American association for cancer research. - 1055-9965 .- 1538-7755. ; 32:3, s. 315-328
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: Tobacco smoking is an established risk factor for colorectal cancer. However, genetically defined population subgroups may have increased susceptibility to smoking-related effects on colorectal cancer.METHODS: A genome-wide interaction scan was performed including 33,756 colorectal cancer cases and 44,346 controls from three genetic consortia.RESULTS: Evidence of an interaction was observed between smoking status (ever vs. never smokers) and a locus on 3p12.1 (rs9880919, P = 4.58 × 10-8), with higher associated risk in subjects carrying the GG genotype [OR, 1.25; 95% confidence interval (CI), 1.20-1.30] compared with the other genotypes (OR <1.17 for GA and AA). Among ever smokers, we observed interactions between smoking intensity (increase in 10 cigarettes smoked per day) and two loci on 6p21.33 (rs4151657, P = 1.72 × 10-8) and 8q24.23 (rs7005722, P = 2.88 × 10-8). Subjects carrying the rs4151657 TT genotype showed higher risk (OR, 1.12; 95% CI, 1.09-1.16) compared with the other genotypes (OR <1.06 for TC and CC). Similarly, higher risk was observed among subjects carrying the rs7005722 AA genotype (OR, 1.17; 95% CI, 1.07-1.28) compared with the other genotypes (OR <1.13 for AC and CC). Functional annotation revealed that SNPs in 3p12.1 and 6p21.33 loci were located in regulatory regions, and were associated with expression levels of nearby genes. Genetic models predicting gene expression revealed that smoking parameters were associated with lower colorectal cancer risk with higher expression levels of CADM2 (3p12.1) and ATF6B (6p21.33).CONCLUSIONS: Our study identified novel genetic loci that may modulate the risk for colorectal cancer of smoking status and intensity, linked to tumor suppression and immune response.IMPACT: These findings can guide potential prevention treatments.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...
Carreras-Torres, ...
Kim, Andre E.
Lin, Yi
Díez-Obrero, Vir ...
Bien, Stephanie ...
Qu, Conghui
visa fler...
Wang, Jun
Dimou, Niki
Aglago, Elom K.
Albanes, Demetri ...
Arndt, Volker
Baurley, James W ...
Berndt, Sonja I.
Bézieau, Stéphan ...
Bishop, D Timoth ...
Bouras, Emmanoui ...
Brenner, Hermann
Budiarto, Arif
Campbell, Peter ...
Casey, Graham
Chan, Andrew T.
Chang-Claude, Je ...
Chen, Xuechen
Conti, David V.
Dampier, Christo ...
Devall, Matthew ...
Drew, David A.
Figueiredo, Jane ...
Gallinger, Steve ...
Giles, Graham G.
Gruber, Stephen ...
Gsur, Andrea
Gunter, Marc J.
Harrison, Tabith ...
Hidaka, Akihisa
Hoffmeister, Mic ...
Huyghe, Jeroen R ...
Jenkins, Mark A.
Jordahl, Kristin ...
Kawaguchi, Eric
Keku, Temitope O ...
Kundaje, Anshul
Le Marchand, Loi ...
Lewinger, Juan P ...
Li, Li
Mahesworo, Bharu ...
Morrison, John L ...
Murphy, Neil
Nan, Hongmei
Nassir, Rami
Newcomb, Polly A ...
Obón-Santacana, ...
Ogino, Shuji
Ose, Jennifer
Pai, Rish K.
Palmer, Julie R.
Papadimitriou, N ...
Pardamean, Bens
Peoples, Anita R ...
Pharoah, Paul D ...
Platz, Elizabeth ...
Rennert, Gad
Ruiz-Narvaez, Ed ...
Sakoda, Lori C.
Scacheri, Peter ...
Schmit, Stephani ...
Schoen, Robert E ...
Shcherbina, Anna
Slattery, Martha ...
Stern, Mariana C ...
Su, Yu-Ru
Tangen, Catherin ...
Thomas, Duncan C ...
Tian, Yu
Tsilidis, Konsta ...
Ulrich, Cornelia ...
van Duijnhoven, ...
van Guelpen, Bet ...
Visvanathan, Kal ...
Vodicka, Pavel
Cenggoro, Tjeng ...
Weinstein, Steph ...
White, Emily
Wolk, Alicja
Woods, Michael O ...
Hsu, Li
Peters, Ulrike
Moreno, Victor
Gauderman, W. Ja ...
visa färre...
Om ämnet
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Klinisk medicin
och Cancer och onkol ...
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Medicinska och f ...
och Medicinsk geneti ...
Artiklar i publikationen
Cancer Epidemiol ...
Av lärosätet
Umeå universitet
Karolinska Institutet

Sök utanför SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy