Neural tissue xenotransplantation : What Is Needed Prior to Clinical Trials in Parkinson’s Disease?

• Embryonic allografted human tissue in patients with Parkinson's disease has been shown to survive and ameliorate many of the symptoms of this disease. Despite this success, the practical problems of using this tissue coupled to the ethical restrictions of using aborted human fetal tissue have lead to an exploration for alternative sources of suitable material for grafting, including xenogeneic embryonic dopaminergic-rich neural tissue. Nevertheless, xenografted neural tissue itself generates a number of practical, ethical, safety, and immunological issues that have to be addressed prior to any clinical xenotransplant program. In this article we review these critical issues and set out the criteria that we consider need to be met in the development of our clinical xenotransplantation research programs. We advocate that these, or similar, criteria should be adopted and made explicit by other centers contemplating similar clinical trials.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Animals

Brain Tissue Transplantation

Cell Transplantation

Clinical Trials as Topic

Endogenous Retroviruses

Fetal Tissue Transplantation

Gestational Age

Graft Survival

Humans

Immunosuppression

Parkinson Disease

Risk Assessment

Safety

Specific Pathogen-Free Organisms

Swine

Transplantation, Heterologous

Journal Article

Review

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)