Modeling psychological function in patients with schizophrenia with the PANSS: An international multi-center study

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Modeling psychological function in patients with schizophrenia with the PANSS : An international multi-center study

Fountoulakis, K.N. (författare): Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece

Dragioti, Elena, Ph.D. (författare): Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Sweden

Theofilidis, A.T. (författare): 3rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Wiklund, Tobias, 1986- (författare): Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Huddinge, Sweden

Atmatzidis, Xenofon (författare): Linköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Huddinge, Sweden

Nimatoudis, I. (författare): 3rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece

Thys, E. (författare): University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium

Wampers, M. (författare): University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium; Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium

Hranov, L. (författare): University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry sveti Naum, Sofia, Bulgaria

Hristova, T. (författare): University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry sveti Naum, Sofia, Bulgaria

Aptalidis, D. (författare): University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry sveti Naum, Sofia, Bulgaria

Milev, R. (författare): Department of Psychiatry, Queens University, Providence Care Hospital, Kingston, ON, Canada

Iftene, F. (författare): Department of Psychiatry, Queens University, Providence Care Hospital, Kingston, ON, Canada

Spaniel, F. (författare): National Institute of Mental Health, Klecany, Czech Republic

Knytl, P. (författare): National Institute of Mental Health, Klecany, Czech Republic

Furstova, P. (författare): National Institute of Mental Health, Klecany, Czech Republic

From, T. (författare): Department of Psychiatry, University of Turku, Turku, Finland

Karlsson, H. (författare): Department of Psychiatry, University of Turku, Turku, Finland

Walta, M. (författare): Department of Psychiatry, University of Turku, Turku, Finland

Salokangas, R.K.R. (författare): Department of Psychiatry, University of Turku, Turku, Finland

Azorin, J.-M. (författare): Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France; Timone Institute of Neuroscience, Marseille, France

Bouniard, J. (författare): Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France; Timone Institute of Neuroscience, Marseille, France

Montant, J. (författare): Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France; Timone Institute of Neuroscience, Marseille, France

Juckel, G. (författare): Department of Psychiatry, Ruhr University Bochum, Bochum, Germany

Haussleiter, I.S. (författare): Department of Psychiatry, Ruhr University Bochum, Bochum, Germany

Douzenis, A. (författare): 2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece

Michopoulos, I. (författare): 2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece

Ferentinos, P. (författare): 2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece

Smyrnis, N. (författare): Department of Psychiatry, National and Kapodistrian University of Athens School of Medicine, Eginition Hospital, Athens, Greece

Mantonakis, L. (författare): Department of Psychiatry, National and Kapodistrian University of Athens School of Medicine, Eginition Hospital, Athens, Greece

Nemes, Z. (författare): Nyír Gyula Hospital, Budapest, Hungary

Gonda, X. (författare): Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary

Vajda, D. (författare): Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary

Juhasz, A. (författare): Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary

Shrivastava, A. (författare): Western University, London, ON, Canada

Waddington, J. (författare): Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland

Pompili, M. (författare): Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, SantAndrea Hospital, Sapienza University of Rome, Rome, Italy

Comparelli, A. (författare): Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, SantAndrea Hospital, Sapienza University of Rome, Rome, Italy

Corigliano, V. (författare): Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, SantAndrea Hospital, Sapienza University of Rome, Rome, Italy

Rancans, E. (författare): Department of Psychiatry and Narcology, Riga Stradins University, Riga, Latvia

Navickas, A. (författare): Department of Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Department of Psychosocial Rehabilitation, Vilnius Mental Health Center, Vilnius, Lithuania; Department for Psychosis Treatment, Vilnius Mental Health Center, Vilnius, Lithuania

Hilbig, J. (författare): Department of Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Department of Psychosocial Rehabilitation, Vilnius Mental Health Center, Vilnius, Lithuania; Department for Psychosis Treatment, Vilnius Mental Health Center, Vilnius, Lithuania

Bukelskis, L. (författare): Department of Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Department of Psychosocial Rehabilitation, Vilnius Mental Health Center, Vilnius, Lithuania; Department for Psychosis Treatment, Vilnius Mental Health Center, Vilnius, Lithuania

Stevovic, L.I. (författare): Clinical Department of Psychiatry, Clinical Centre of Montenegro, Podgorica, Montenegro; Department of Psychiatry, School of Medicine, University of Montenegro, Podgorica, Montenegro; Clinical Department of Neurology, Clinical Centre of Montenegro, Podgorica, Montenegro

Vodopic, S. (författare): Clinical Department of Psychiatry, Clinical Centre of Montenegro, Podgorica, Montenegro; Department of Psychiatry, School of Medicine, University of Montenegro, Podgorica, Montenegro; Clinical Department of Neurology, Clinical Centre of Montenegro, Podgorica, Montenegro

Esan, O. (författare): Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria

Oladele, O. (författare): Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria

Osunbote, C. (författare): Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria

Rybakowski, J.K. (författare): Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland

Wojciak, P. (författare): Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland

Domowicz, K. (författare): Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland

Figueira, M.L. (författare): Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal

Linhares, L. (författare): Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal

Crawford, J. (författare): Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal

Panfil, A.-L. (författare): University of Medicine and Pharmacy of Târgu Mures, Târgu Mures, Romania

Smirnova, D. (författare): Department of Psychiatry, Samara Psychiatric Hospital, Inpatient Unit, Samara State Medical University, Samara, Russian Federation

Izmailova, O. (författare): Department of Psychiatry, Samara Psychiatric Hospital, Inpatient Unit, Samara State Medical University, Samara, Russian Federation

Lecic-Tosevski, D. (författare): Institute of Mental Health, Belgrade, Serbia; Serbian Academy of Sciences and Arts, Belgrade, Serbia

Temmingh, H. (författare): Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa

Howells, F. (författare): Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa

Bobes, J. (författare): Department of Psychiatry, University of Oviedo, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, Spain

Garcia-Portilla, M.P. (författare): Department of Psychiatry, University of Oviedo, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, Spain

Garciá-Alvarez, L. (författare): Department of Psychiatry, University of Oviedo, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, Spain

Erzin, G. (författare): Psychiatry Department, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey

Karada, H. (författare): Psychiatry Department, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey

De, Sousa A. (författare): Department of Psychiatry, Lokmanya Tilak Municipal Medical College, Mumbai, India

Bendre, A. (författare): Department of Psychiatry, Lokmanya Tilak Municipal Medical College, Mumbai, India

Hoschl, C. (författare): National Institute of Mental Health, Klecany, Czech Republic

Bredicean, C. (författare): University of Medicine, Pharmacy of Timisoara, Timisoara, Romania

Papava, I. (författare): University of Medicine, Pharmacy of Timisoara, Timisoara, Romania

Vukovic, O. (författare): Institute of Mental Health, School of Medicine, University of Belgrade, Belgrade, Serbia

Pejuskovic, B. (författare): Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland

Russell, V. (författare): Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland

Athanasiadis, L. (författare): 1st Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece

Konsta, A. (författare): 1st Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece

Stein, D. (författare): Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa

Berk, M. (författare): IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Australia; Orygen, National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia; Centre for Youth Mental Health, Florey Institute for Neuroscience and Mental Health, Parkville, VIC, Australia; Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia

Dean, O. (författare): IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Australia; Orygen, National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia; Centre for Youth Mental Health, Florey Institute for Neuroscience and Mental Health, Parkville, VIC, Australia; Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia

Tandon, R. (författare): Department of Psychiatry, University of Florida, Gainesville, FL, United States

Kasper, S. (författare): Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria

De, Hert M. (författare): University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium; Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium; Antwerp Health Law and Ethics Chair, AHLEC University, Antwerpen, Belgium

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Cambridge University Press, 2021
2021
Engelska.
Ingår i: CNS Spectrums. - : Cambridge University Press. - 1092-8529 .- 2165-6509. ; 26:3, s. 290-298

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

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Background.The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model.Methods.Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Multiple linear regression analysis and visual inspection of plots were performed.Results.The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement/hostility the second, depression the third, and neurocognitive decline the last stage.Conclusions.The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct “cores” of schizophrenia, the “Positive” and the “Negative,” while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition.

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Av författaren/redakt...: Fountoulakis, K. ...; Dragioti, Elena, ...; Theofilidis, A.T ...; Wiklund, Tobias, ...; Atmatzidis, Xeno ...; Nimatoudis, I.; visa fler...; Thys, E.; Wampers, M.; Hranov, L.; Hristova, T.; Aptalidis, D.; Milev, R.; Iftene, F.; Spaniel, F.; Knytl, P.; Furstova, P.; From, T.; Karlsson, H.; Walta, M.; Salokangas, R.K. ...; Azorin, J.-M.; Bouniard, J.; Montant, J.; Juckel, G.; Haussleiter, I.S ...; Douzenis, A.; Michopoulos, I.; Ferentinos, P.; Smyrnis, N.; Mantonakis, L.; Nemes, Z.; Gonda, X.; Vajda, D.; Juhasz, A.; Shrivastava, A.; Waddington, J.; Pompili, M.; Comparelli, A.; Corigliano, V.; Rancans, E.; Navickas, A.; Hilbig, J.; Bukelskis, L.; Stevovic, L.I.; Vodopic, S.; Esan, O.; Oladele, O.; Osunbote, C.; Rybakowski, J.K.; Wojciak, P.; Domowicz, K.; Figueira, M.L.; Linhares, L.; Crawford, J.; Panfil, A.-L.; Smirnova, D.; Izmailova, O.; Lecic-Tosevski, ...; Temmingh, H.; Howells, F.; Bobes, J.; Garcia-Portilla, ...; Garciá-Alvarez, ...; Erzin, G.; Karada, H.; De, Sousa A.; Bendre, A.; Hoschl, C.; Bredicean, C.; Papava, I.; Vukovic, O.; Pejuskovic, B.; Russell, V.; Athanasiadis, L.; Konsta, A.; Stein, D.; Berk, M.; Dean, O.; Tandon, R.; Kasper, S.; De, Hert M.; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

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Av lärosätet: Linköpings universitet

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Modeling psychological function in patients with schizophrenia with the PANSS : An international multi-center study

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