Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12

• We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 10-9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Keyword

Aged

Chromosome Mapping

Chromosomes; Human; Pair 17/*genetics

Genetic Predisposition to Disease/*genetics

Haplotypes/*genetics

Hepatocyte Nuclear Factor 1-beta/*genetics

Humans

Linkage (Genetics)

Male

Middle Aged

Polymorphism; Single Nucleotide/*genetics

Prostatic Neoplasms/*genetics/pathology

Risk Factors

MEDICINE

MEDICIN

Clinical genetics

Klinisk genetik

Medical Genetics

Medicinsk genetik

Publication and Content Type

vet (subject category)

art (subject category)