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The CCND1 c.870G > A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma

Weinhold, Niels (author)
Johnson, David C. (author)
Chubb, Daniel (author)
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Chen, Bowang (author)
Försti, Asta (author)
Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
Hosking, Fay J. (author)
Broderick, Peter (author)
Ma, Yussanne P. (author)
Dobbins, Sara E. (author)
Hose, Dirk (author)
Walker, Brian A. (author)
Davies, Faith E. (author)
Kaiser, Martin F. (author)
Li, Ni L. (author)
Gregory, Walter A. (author)
Jackson, Graham H. (author)
Witzens-Harig, Mathias (author)
Neben, Kai (author)
Hoffmann, Per (author)
Noethen, Markus M. (author)
Muehleisen, Thomas W. (author)
Eisele, Lewin (author)
Ross, Fiona M. (author)
Jauch, Anna (author)
Goldschmidt, Hartmut (author)
Houlston, Richard S. (author)
Morgan, Gareth J. (author)
Hemminki, Kari (author)
Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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 (creator_code:org_t)
2013-03-17
2013
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:5, s. 522-525
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 x 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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