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Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study

Ou, Anna H. (author)
Rosenthal, Sara B. (author)
Adli, Mazda (author)
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Akiyama, Kazufumi (author)
Akula, Nirmala (author)
Alda, Martin (author)
Amare, Azmeraw T. (author)
Ardau, Raffaella (author)
Arias, Barbara (author)
Aubry, Jean-Michel (author)
Backlund, Lena (author)
Bauer, Michael (author)
Baune, Bernhard T. (author)
Bellivier, Frank (author)
Benabarre, Antonio (author)
Bengesser, Susanne (author)
Bhattacharjee, Abesh Kumar (author)
Biernacka, Joanna M. (author)
Cervantes, Pablo (author)
Chen, Guo-Bo (author)
Chen, Hsi-Chung (author)
Chillotti, Caterina (author)
Cichon, Sven (author)
Clark, Scott R. (author)
Colom, Francesc (author)
Cousins, David A. (author)
Cruceanu, Cristiana (author)
Czerski, Piotr M. (author)
Dantas, Clarissa R. (author)
Dayer, Alexandre (author)
Del Zompo, Maria (author)
Degenhardt, Franziska (author)
DePaulo, J. Raymond (author)
Etain, Bruno (author)
Falkai, Peter (author)
Fellendorf, Frederike Tabea (author)
Ferensztajn-Rochowiak, Ewa (author)
Forstner, Andreas J. (author)
Frisen, Louise (author)
Karolinska Institutet
Frye, Mark A. (author)
Fullerton, Janice M. (author)
Gard, Sebastien (author)
Garnham, Julie S. (author)
Goes, Fernando S. (author)
Grigoroiu-Serbanescu, Maria (author)
Grof, Paul (author)
Gruber, Oliver (author)
Hashimoto, Ryota (author)
Hauser, Joanna (author)
Heilbronner, Urs (author)
Herms, Stefan (author)
Hoffmann, Per (author)
Hofmann, Andrea (author)
Hou, Liping (author)
Jamain, Stephane (author)
Jimenez, Esther (author)
Kahn, Jean-Pierre (author)
Kassem, Layla (author)
Kato, Tadafumi (author)
Kittel-Schneider, Sarah (author)
Koenig, Barbara (author)
Kuo, Po-Hsiu (author)
Kusumi, Ichiro (author)
Lackner, Nina (author)
Laje, Gonzalo (author)
Landén, Mikael, 1966 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
Lavebratt, Catharina (author)
Leboyer, Marion (author)
Leckband, Susan G. (author)
Lopez Jaramillo, Carlos A. (author)
MacQueen, Glenda (author)
Maj, Mario (author)
Manchia, Mirko (author)
Marie-Claire, Cynthia (author)
Martinsson, Lina (author)
Karolinska Institutet
Mattheisen, Manuel (author)
McCarthy, Michael J. (author)
McElroy, Susan L. (author)
McMahon, Francis J. (author)
Mitchell, Philip B. (author)
Mitjans, Marina (author)
Mondimore, Francis M. (author)
Monteleone, Palmiero (author)
Nievergelt, Caroline M. (author)
Noethen, Markus M. (author)
Novak, Tomas (author)
Oesby, Urban (author)
Ozaki, Norio (author)
Papiol, Sergi (author)
Perlis, Roy H. (author)
Pisanu, Claudia (author)
Potash, James B. (author)
Pfennig, Andrea (author)
Reich-Erkelenz, Daniela (author)
Reif, Andreas (author)
Reininghaus, Eva Z. (author)
Rietschel, Marcella (author)
Rouleau, Guy A. (author)
Rybakowski, Janusz K. (author)
Schalling, Martin (author)
Schofield, Peter R. (author)
Schubert, K. Oliver (author)
Schulze, Thomas G. (author)
Schweizer, Barbara W. (author)
Seemueller, Florian (author)
Severino, Giovanni (author)
Shekhtman, Tatyana (author)
Shilling, Paul D. (author)
Shimoda, Kazutaka (author)
Simhandl, Christian (author)
Slaney, Claire M. (author)
Squassina, Alessio (author)
Stamm, Thomas (author)
Stopkova, Pavla (author)
Tighe, Sarah K. (author)
Tortorella, Alfonso (author)
Turecki, Gustavo (author)
Vieta, Eduard (author)
Volkert, Julia (author)
Witt, Stephanie (author)
Wray, Naomi R. (author)
Wright, Adam (author)
Young, L. Trevor (author)
Zandi, Peter P. (author)
Kelsoe, John R. (author)
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 (creator_code:org_t)
2024
2024
English.
In: TRANSLATIONAL PSYCHIATRY. - 2158-3188. ; 14:1
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

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art (subject category)

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By the author/editor
Ou, Anna H.
Rosenthal, Sara ...
Adli, Mazda
Akiyama, Kazufum ...
Akula, Nirmala
Alda, Martin
show more...
Amare, Azmeraw T ...
Ardau, Raffaella
Arias, Barbara
Aubry, Jean-Mich ...
Backlund, Lena
Bauer, Michael
Baune, Bernhard ...
Bellivier, Frank
Benabarre, Anton ...
Bengesser, Susan ...
Bhattacharjee, A ...
Biernacka, Joann ...
Cervantes, Pablo
Chen, Guo-Bo
Chen, Hsi-Chung
Chillotti, Cater ...
Cichon, Sven
Clark, Scott R.
Colom, Francesc
Cousins, David A ...
Cruceanu, Cristi ...
Czerski, Piotr M ...
Dantas, Clarissa ...
Dayer, Alexandre
Del Zompo, Maria
Degenhardt, Fran ...
DePaulo, J. Raym ...
Etain, Bruno
Falkai, Peter
Fellendorf, Fred ...
Ferensztajn-Roch ...
Forstner, Andrea ...
Frisen, Louise
Frye, Mark A.
Fullerton, Janic ...
Gard, Sebastien
Garnham, Julie S ...
Goes, Fernando S ...
Grigoroiu-Serban ...
Grof, Paul
Gruber, Oliver
Hashimoto, Ryota
Hauser, Joanna
Heilbronner, Urs
Herms, Stefan
Hoffmann, Per
Hofmann, Andrea
Hou, Liping
Jamain, Stephane
Jimenez, Esther
Kahn, Jean-Pierr ...
Kassem, Layla
Kato, Tadafumi
Kittel-Schneider ...
Koenig, Barbara
Kuo, Po-Hsiu
Kusumi, Ichiro
Lackner, Nina
Laje, Gonzalo
Landén, Mikael, ...
Lavebratt, Catha ...
Leboyer, Marion
Leckband, Susan ...
Lopez Jaramillo, ...
MacQueen, Glenda
Maj, Mario
Manchia, Mirko
Marie-Claire, Cy ...
Martinsson, Lina
Mattheisen, Manu ...
McCarthy, Michae ...
McElroy, Susan L ...
McMahon, Francis ...
Mitchell, Philip ...
Mitjans, Marina
Mondimore, Franc ...
Monteleone, Palm ...
Nievergelt, Caro ...
Noethen, Markus ...
Novak, Tomas
Oesby, Urban
Ozaki, Norio
Papiol, Sergi
Perlis, Roy H.
Pisanu, Claudia
Potash, James B.
Pfennig, Andrea
Reich-Erkelenz, ...
Reif, Andreas
Reininghaus, Eva ...
Rietschel, Marce ...
Rouleau, Guy A.
Rybakowski, Janu ...
Schalling, Marti ...
Schofield, Peter ...
Schubert, K. Oli ...
Schulze, Thomas ...
Schweizer, Barba ...
Seemueller, Flor ...
Severino, Giovan ...
Shekhtman, Tatya ...
Shilling, Paul D ...
Shimoda, Kazutak ...
Simhandl, Christ ...
Slaney, Claire M ...
Squassina, Aless ...
Stamm, Thomas
Stopkova, Pavla
Tighe, Sarah K.
Tortorella, Alfo ...
Turecki, Gustavo
Vieta, Eduard
Volkert, Julia
Witt, Stephanie
Wray, Naomi R.
Wright, Adam
Young, L. Trevor
Zandi, Peter P.
Kelsoe, John R.
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Psychiatry
Articles in the publication
TRANSLATIONAL PS ...
By the university
University of Gothenburg
Karolinska Institutet

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