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Sökning: onr:"swepub:oai:DiVA.org:uu-422072" > Carotenoid intakes ...

Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status : a pooled analysis of 18 prospective cohort studies

Zhang, Xuehong (författare)
Harvard Univ, Sch Publ Hlth, Channing Lab, Landmark Ctr,Dept Nutr, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
Spiegelman, Donna (författare)
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
Baglietto, Laura (författare)
Canc Council Victoria, Canc Epidemiol Ctr, Carlton, Vic, Australia.;Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic 3010, Australia.
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Bernstein, Leslie (författare)
City Hope Natl Med Ctr, Beckman Res Inst, Div Canc Etiol, Dept Populat Sci, Duarte, CA 91010 USA.
Boggs, Deborah A. (författare)
Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA.
van den Brandt, Piet A. (författare)
Maastricht Univ, GROW Sch Oncol & Dev Biol, Dept Epidemiol, Maastricht, Netherlands.
Buring, Julie E. (författare)
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.
Gapstur, Susan M. (författare)
Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
Giles, Graham G. (författare)
Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic 3010, Australia.
Giovannucci, Edward (författare)
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.;Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA.
Goodman, Gary (författare)
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA.
Hankinson, Susan E. (författare)
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.;Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA.
Helzlsouer, Kathy J. (författare)
Mercy Med Ctr, Weinberg Ctr Womens Hlth & Med, Prevent & Res Ctr, Baltimore, MD USA.;Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
Horn-Ross, Pamela L. (författare)
Canc Prevent Inst Calif, Fremont, CA USA.
Inoue, Manami (författare)
Natl Canc Ctr, Res Ctr Canc Prevent & Screening, Epidemiol & Prevent Div, Tokyo 104, Japan.
Jung, Seungyoun (författare)
Khudyakov, Polyna (författare)
Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
Larsson, Susanna C. (författare)
Karolinska Institutet
Lof, Marie (författare)
Karolinska Institutet
McCullough, Marjorie L. (författare)
Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
Miller, Anthony B. (författare)
Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
Neuhouser, Marian L. (författare)
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA.
Palmer, Julie R. (författare)
Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA.
Park, Yikyung (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Robien, Kim (författare)
Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.
Rohan, Thomas E. (författare)
Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
Ross, Julie A. (författare)
Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.
Schouten, Leo J. (författare)
Maastricht Univ, GROW Sch Oncol & Dev Biol, Dept Epidemiol, Maastricht, Netherlands.
Shikany, James M. (författare)
Univ Alabama Birmingham, Sch Med, Div Prevent Med, Birmingham, AL USA.
Tsugane, Shoichiro (författare)
Natl Canc Ctr, Res Ctr Canc Prevent & Screening, Epidemiol & Prevent Div, Tokyo 104, Japan.
Visvanathan, Kala (författare)
Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
Weiderpass, Elisabete (författare)
Karolinska Institutet
Wolk, Alicja (författare)
Karolinska Institutet
Willett, Walter C. (författare)
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.;Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA.
Zhang, Shumin M. (författare)
Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.
Ziegler, Regina G. (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Smith-Warner, Stephanie A. (författare)
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
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Harvard Univ, Sch Publ Hlth, Channing Lab, Landmark Ctr,Dept Nutr, Boston, MA 02115 USA;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. (creator_code:org_t)
OXFORD UNIV PRESS, 2012
2012
Engelska.
Ingår i: American Journal of Clinical Nutrition. - : OXFORD UNIV PRESS. - 0002-9165 .- 1938-3207. ; 95:3, s. 713-725
Relaterad länk:
https://academic.oup...
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https://urn.kb.se/re...
https://doi.org/10.3...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Epidemiologic studies examining associations between carotenoid intakes and risk of breast cancer by estrogen receptor (ER) and progesterone receptor (PR) status are limited. Objective: We investigated these associations in a pooled analysis of 18 cohort studies. Design: Of 1,028,438 participants followed for a maximum follow-up of 26 y across studies, 33,380 incident invasive breast cancers were identified. Study-specific RRs and 95% CIs were estimated by using Cox proportional hazards regression and then pooled by using a random-effects model. Results: alpha-Carotene, beta-carotene, and lutein/zeaxanthin intakes were inversely associated with the risk of ER-negative (ER-) breast cancer (pooled multivariable RRs of the comparison between the highest and lowest quintiles): alpha-carotene (0.87; 95% CI: 0.78, 0.97), beta-carotene (0.84; 95% CI: 0.77, 0.93), and lutein/zeaxanthin (0.87; 95% CI: 0.79, 0.95). These variables were not inversely associated with the risk of ER-positive (ER+) breast cancer (pooled multivariable RRs for the same comparison): a-carotene (1.04; 95% CI: 0.99, 1.09), beta-carotene (1.04; 95% CI: 0.98, 1.10), and lutein/zeaxanthin (1.00; 95% CI: 0.93, 1.07). Although the pooled RRs for quintile 5 for beta-cryptoxanthin were not significant, inverse trends were observed for ER- and ER+ breast cancer (P-trend <= 0.05). Nonsignificant associations were observed for lycopene intake. The associations were largely not appreciably modified by several breast cancer risk factors. Nonsignificant associations were observed for PR-positive and PR-negative breast cancer. Conclusions: Intakes of alpha-carotene, beta-carotene, and lutein/zeaxanthin were inversely associated with risk of ER-, but not ER+, breast cancer. However, the results need to be interpreted with caution because it is unclear whether the observed association is real or due to other constituents in the same food sources. Am J Clin Nutr 2012;95:713-25.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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