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Sökning: onr:"swepub:oai:DiVA.org:uu-462111" > Focal amplification...

Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

Zhao, Xue-Ke (författare)
Zhengzhou Univ, Affiliated Hosp 1, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou 450052, Henan, Peoples R China.
Xing, Pengwei (författare)
Uppsala universitet,Molekylära verktyg
Song, Xin (författare)
Zhengzhou Univ, Affiliated Hosp 1, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou 450052, Henan, Peoples R China.
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Zhao, Miao (författare)
Uppsala universitet,Neuroonkologi
Zhao, Linxuan (författare)
Uppsala universitet,Institutionen för immunologi, genetik och patologi
Dang, Yonglong (författare)
Uppsala universitet,Molekylära verktyg
Lei, Ling-Ling (författare)
Zhengzhou Univ, Affiliated Hosp 1, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou 450052, Henan, Peoples R China.
Xu, Rui-Hua (författare)
Zhengzhou Univ, Affiliated Hosp 1, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou 450052, Henan, Peoples R China.
Han, Wen-Li (författare)
Zhengzhou Univ, Affiliated Hosp 1, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou 450052, Henan, Peoples R China.
Wang, Pan-Pan (författare)
Zhengzhou Univ, Affiliated Hosp 1, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou 450052, Henan, Peoples R China.
Yang, Miao-Miao (författare)
Zhengzhou Univ, Affiliated Hosp 1, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou 450052, Henan, Peoples R China.
Hu, Jing-Feng (författare)
Zhengzhou Univ, Affiliated Hosp 1, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou 450052, Henan, Peoples R China.
Zhong, Kan (författare)
Zhengzhou Univ, Affiliated Hosp 1, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou 450052, Henan, Peoples R China.
Zhou, Fu-You (författare)
Zhengzhou Univ, Affiliated Hosp 1, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou 450052, Henan, Peoples R China.
Han, Xue-Na (författare)
Zhengzhou Univ, Affiliated Hosp 1, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou 450052, Henan, Peoples R China.
Meng, Chao-Long (författare)
Zhengzhou Univ, Affiliated Hosp 1, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou 450052, Henan, Peoples R China.
Ji, Jia-Jia (författare)
Zhengzhou Univ, Affiliated Hosp 1, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou 450052, Henan, Peoples R China.
Chen, Xingqi (författare)
Uppsala universitet,Molekylära verktyg
Wang, Li-Dong (författare)
Zhengzhou Univ, Affiliated Hosp 1, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou 450052, Henan, Peoples R China.
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Zhengzhou Univ, Affiliated Hosp 1, State Key Lab Esophageal Canc Prevent & Treatment, Zhengzhou 450052, Henan, Peoples R China;Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou 450052, Henan, Peoples R China. Molekylära verktyg (creator_code:org_t)
2021-11-11
2021
Engelska.
Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 12
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://www.nature.c...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The role of focal amplifications and extrachromosomal DNA (ecDNA) is unknown in gastric cardia adenocarcinoma (GCA). Here, we identify frequent focal amplifications and ecDNAs in Chinese GCA patient samples, and find focal amplifications in the GCA cohort are associated with the chromothripsis process and may be induced by accumulated DNA damage due to local dietary habits. We observe diverse correlations between the presence of oncogene focal amplifications and prognosis, where ERBB2 focal amplifications positively correlate with prognosis and EGFR focal amplifications negatively correlate with prognosis. Large-scale ERBB2 immunohistochemistry results from 1668 GCA patients show survival probability of ERBB2 positive patients is lower than that of ERBB2 negative patients when their surviving time is under 2 years, however, the tendency is opposite when their surviving time is longer than 2 years. Our observations indicate that the ERBB2 focal amplifications may represent a good prognostic marker in GCA patients.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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