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Lysine demethylase ...
Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness
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- Zhao, Li-Juan (författare)
- Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
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- Li, Ying-Ying (författare)
- Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
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- Zhang, Yu-Tong (författare)
- Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
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- Fan, Qi-Qi (författare)
- Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
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- Ren, Hong-Mei (författare)
- Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
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- Zhang, Cheng (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
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- Mardinoglu, Adil (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kings Coll London, Ctr Host Microbiome Interact, Fac Dent Oral & Craniofacial Sci, London, England.
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- Chen, Wen-Chao (författare)
- Zhengzhou Univ, Henan Prov Peoples Hosp, Dept Gastrointestinal Surg, Zhengzhou, Peoples R China.
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- Pang, Jing-Ru (författare)
- Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
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- Shen, Dan-Dan (författare)
- Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
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- Wang, Jun-Wei (författare)
- Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
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- Zhao, Long-Fei (författare)
- Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
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- Zhang, Jian-Ying (författare)
- Zhengzhou Univ, Henan Inst Med & Pharmaceut Sci, Zhengzhou, Peoples R China.
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- Wang, Zhen-Ya (författare)
- Zhengzhou Univ, Inst Drug Discovery & Dev, Key Lab Runliang Antiviral Medicines Res & Dev, Zhengzhou, Peoples R China.
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- Zheng, Yi-Chao (författare)
- Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
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- Liu, Hong-Min (författare)
- Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.
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Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China. Science for Life Laboratory, SciLifeLab (creator_code:org_t)
- 2021-05-31
- 2021
- Engelska.
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Ingår i: EMBO Reports. - : EMBO. - 1469-221X .- 1469-3178. ; 22:8
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Several studies have examined the functions of nucleic acids in small extracellular vesicles (sEVs). However, much less is known about the protein cargos of sEVs and their functions in recipient cells. This study demonstrates the presence of lysine-specific demethylase 1 (LSD1), which is the first identified histone demethylase, in the culture medium of gastric cancer cells. We show that sEVs derived from gastric cancer cells and the plasma of patients with gastric cancer harbor LSD1. The shuttling of LSD1-containing sEVs from donor cells to recipient gastric cancer cells promotes cancer cell stemness by positively regulating the expression of Nanog, OCT4, SOX2, and CD44. Additionally, sEV-delivered LSD1 suppresses oxaliplatin response of recipient cells in vitro and in vivo, whereas LSD1-depleted sEVs do not. Taken together, we demonstrate that LSD1-loaded sEVs can promote stemness and chemoresistance to oxaliplatin. These findings suggest that the LSD1 content of sEV could serve as a biomarker to predict oxaliplatin response in gastric cancer patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- gastric cancer
- LSD1
- small extracellular vesicles
- stemness
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Zhao, Li-Juan
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Li, Ying-Ying
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Zhang, Yu-Tong
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Fan, Qi-Qi
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Ren, Hong-Mei
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Zhang, Cheng
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visa fler...
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Mardinoglu, Adil
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Chen, Wen-Chao
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Pang, Jing-Ru
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Shen, Dan-Dan
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Wang, Jun-Wei
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Zhao, Long-Fei
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Zhang, Jian-Ying
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Wang, Zhen-Ya
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Zheng, Yi-Chao
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Liu, Hong-Min
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