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Biomarker Profiles ...
Biomarker Profiles in Heart Failure Patients With Preserved and Reduced Ejection Fraction
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Tromp, Jasper (författare)
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Khan, Mohsin A. F. (författare)
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Klip, IJsbrand T. (författare)
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visa fler...
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Meyer, Sven (författare)
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de Boer, Rudolf A. (författare)
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Jaarsma, Tiny (författare)
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Hillege, Hans (författare)
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van Veldhuisen, Dirk J. (författare)
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van der Meer, Peter (författare)
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Voors, Adriaan A. (författare)
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visa färre...
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(utgivare)
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(utgivare)
- WILEY 2017
- 2017
- Engelska.
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Ingår i: Journal of the American Heart Association. - 2047-9980. ; 6:4
Abstract
Ämnesord
Stäng
- Background-Biomarkers may help us to unravel differences in the underlying pathophysiology between heart failure (HF) patients with a reduced ejection fraction (HFrEF) and a preserved ejection fraction (HFpEF). Therefore, we compared biomarker profiles to characterize pathophysiological differences between patients with HFrEF and HFpEF. Methods and Results-We retrospectively analyzed 33 biomarkers from different pathophysiological domains (inflammation, oxidative stress, remodeling, cardiac stretch, angiogenesis, arteriosclerosis, and renal function) in 460 HF patients (21% HFpEF, left ventricular ejection fraction amp;gt;= 45%) measured at discharge after hospitalization for acute HF. The association between these markers and the occurrence of all-cause mortality and/or HF-related rehospitalizations at 18 months was compared between patients with HFrEF and HFpEF. Patients were 70.6 +/- 11.4 years old and 37.4% were female. Patients with HFpEF were older, more often female, and had a higher systolic blood pressure. Levels of high-sensitive C-reactive protein were significantly higher in HFpEF, while levels of pro-atrial-type natriuretic peptide and N-terminal pro-brain natriuretic peptide were higher in HFrEF. Linear regression followed by network analyses revealed prominent inflammation and angiogenesis-associated interactions in HFpEF and mainly cardiac stretch-associated interactions in HrEF. The angiogenesis-specific marker, neuropilin and the remodeling-specific marker, osteopontin were predictive for all-cause mortality and/or HF-related rehospitalizations at 18 months in HFpEF, but not in HFrEF (P for interaction amp;lt;0.05). Conclusions-In HFpEF, inflammation and angiogenesis- mediated interactions are predominantly observed, while stretch-mediated interactions are found in HFrEF. The remodeling marker osteopontin and the angiogenesis marker neuropilin predicted outcome in HFpEF, but not in HFrEF.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Cardiac and Cardiovascular Systems (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Kardiologi (hsv)
Nyckelord
- biomarker; heart failure; multimarker; pathophysiology
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Till lärosätets databas
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Tromp, Jasper
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Khan, Mohsin A. ...
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Klip, IJsbrand T ...
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Meyer, Sven
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de Boer, Rudolf ...
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Jaarsma, Tiny
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visa fler...
-
Hillege, Hans
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van Veldhuisen, ...
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van der Meer, Pe ...
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Voors, Adriaan A ...
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visa färre...
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