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Dysregulated Lipid Metabolism Precedes Onset of Psychosis

Dickens, Alex M. (author)
Turku Bioscience Center, University of Turku and Åbo Akademi University, Turku, Finland
Sen, Partho (author)
Turku Bioscience Center, University of Turku and Åbo Akademi University, Turku, Finland
Kempton, Matthew J. (author)
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
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Barrantes-Vidal, Neus (author)
Departament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona, Fundació Sanitària Sant Pere Claver, Spanish Mental Health Research Network, Barcelona, Spain
Iyegbe, Conrad (author)
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
Nordentoft, Merete (author)
Mental Health Center Copenhagen and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Mental Health Services in the Capital Region of Copenhagen, University of Copenhagen, Glostrup, Denmark
Pollak, Thomas (author)
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
Riecher-Rössler, Anita (author)
University Psychiatric Hospital, Basel, Switzerland
Ruhrmann, Stephan (author)
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Sachs, Gabriele (author)
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
Bressan, Rodrigo (author)
Lab Interdisciplinar Neurociências Clínicas, Departimento Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
Krebs, Marie-Odile (author)
University of Paris, Groupe Hospitalier Universitaire Paris Sainte-Anne, Centre d'Évaluation Pour Jeunes Adultes et Adolescents, Institut National de la Santé et de la Recherche Médicale, Institut de Psychiatrie, Paris, France
Amminger, G. Paul (author)
Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia
de Haan, Lieuwe (author)
Department of Psychiatry, Amsterdam University Medical Center, Faculty of Behavioural and Movement Sciences, Vrije Universiteit, Amsterdam, The Netherlands
van der Gaag, Mark (author)
Department of Clinical Psychology and EMGO+ Institute for Health and Care Research, Faculty of Behavioural and Movement Sciences, Vrije Universiteit, Amsterdam, The Netherlands; Department of Psychosis Research, Parnassia Psychiatric Institute, The Hague, The Netherlands
Valmaggia, Lucia (author)
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
Hyötyläinen, Tuulia, 1971- (author)
Örebro universitet,Institutionen för naturvetenskap och teknik
Oresic, Matej, 1967- (author)
Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Center, University of Turku and Åbo Akademi University, Turku, Finland
McGuire, Philip (author)
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
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 (creator_code:org_t)
Elsevier, 2021
2021
English.
In: Biological Psychiatry. - : Elsevier. - 0006-3223 .- 1873-2402. ; 89:3, s. 288-297
Related links:
https://doi.org/10.1...
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https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • BACKGROUND: A key clinical challenge in the management of individuals at clinical high risk for psychosis (CHR) is that it is difficult to predict their future clinical outcomes. Here, we investigated if the levels of circulating molecular lipids are related to adverse clinical outcomes in this group.METHODS: Serum lipidomic analysis was performed in 263 CHR individuals and 51 healthy control subjects, who were then clinically monitored for up to 5 years. Machine learning was used to identify lipid profiles that discriminated between CHR and control subjects, and between subgroups of CHR subjects with distinct clinical outcomes.RESULTS: At baseline, compared with control subjects, CHR subjects (independent of outcome) had higher levels of triacylglycerols with a low acyl carbon number and a double bond count, as well as higher levels of lipids in general. CHR subjects who subsequently developed psychosis (n = 50) were distinguished from those that did not (n = 213) on the basis of lipid profile at baseline using a model with an area under the receiver operating curve of 0.81 (95% confidence interval = 0.69-0.93). CHR subjects who became psychotic had lower levels of ether phospholipids than CHR individuals who did not (p < .01).CONCLUSIONS: Collectively, these data suggest that lipidomic abnormalities predate the onset of psychosis and that blood lipidomic measures may be useful in predicting which CHR individuals are most likely to develop psychosis.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Keyword

At-risk mental state
Clinical high risk for psychosis
Lipid metabolism
Lipidomics
Mass spectrometry
Schizophrenia

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