Sökning: WFRF:(van Vollenhoven Ronald) >
Time-dependent incr...
Time-dependent increase in risk of hospitalisation with infection among Swedish RA patients treated with TNF antagonists
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- Askling, Johan (författare)
- Karolinska Institutet
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- Fored, C. Michael (författare)
- Karolinska Institutet
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- Brandt, Lena (författare)
- Karolinska Institutet
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visa fler...
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- Baecklund, Eva (författare)
- Uppsala universitet,Reumatologi
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Bertilsson, Lennart (författare)
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Feltelius, Nils (författare)
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- Cöster, Lars, 1945- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Reumatologi,Länskliniken för Reumatologi i Östergötland
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- Geborek, Pierre (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Jacobsson, Lennart (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Lindblad, Staffan (författare)
- Karolinska Institutet
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Lysholm, Jörgen (författare)
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- Rantapää-Dahlqvist, Solbritt (författare)
- Umeå universitet,Reumatologi
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- Saxne, Tore (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- van Vollenhoven, Ronald F. (författare)
- Karolinska Institutet
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- Klareskog, Lars (författare)
- Karolinska Institutet
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(creator_code:org_t)
- BMJ, 2007
- 2007
- Engelska.
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 66:10, s. 1339-1344
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Abstract
Ämnesord
Stäng
- OBJECTIVES:The degree to which treatment with tumour necrosis factor (TNF) antagonists may be associated with increased risks for serious infections is unclear. An observational cohort study was performed using prospectively collected data from the Swedish Biologics Register (ARTIS) and other national Swedish registers.METHODS:First, in the ARTIS, all 4167 rheumatoid arthritis (RA) patients starting TNF antagonist treatment between 1999 and 2003 were identified. Secondly, in the Swedish Inpatient Register, all individuals hospitalised for any reason and who also carried a diagnosis of RA, between 1964 and 2003 (n = 44 946 of whom 2692 also occurred in ARTIS), were identified. Thirdly, in the Swedish Inpatient Register, all hospitalisations listing an infection between 1999 and 2003 were identified. By cross-referencing these three data sets, RRs for hospitalisation with infection associated with TNF antagonist treatment were calculated within the cohort of 44 946 RA patients, using Cox regression taking sex, age, geography, co-morbidity and use of inpatient care into account.RESULTS:Among the 4167 patients treated with TNF antagonists, 367 hospitalisations with infections occurred during 7776 person-years. Within the cohort of 44 496 RA patients, the RR for infection associated with TNF antagonists was 1.43 (95% CI 1.18 to 1.73) during the first year of treatment, 1.15 (95% CI 0.88 to 1.51) during the second year of treatment, and 0.82 (95% CI 0.62 to 1.08) for subjects remaining on their first TNF antagonist treatment after 2 years.CONCLUSION:Treatment with TNF antagonists may be associated with a small to moderate increase in risk of hospitalisation with infection, which disappears with increasing treatment duration.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Immunopathology
- Diseases of the osteoarticular system
- Inflammatory joint disease
- Autoimmune disease
- Chronic
- Diagnosis
- Antagonist
- Tumor necrosis factor
- Treatment
- Human
- Infection
- Risk factor
- Rheumatoid arthritis
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Askling, Johan
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Fored, C. Michae ...
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Brandt, Lena
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Baecklund, Eva
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Bertilsson, Lenn ...
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Feltelius, Nils
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visa fler...
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Cöster, Lars, 19 ...
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Geborek, Pierre
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Jacobsson, Lenna ...
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Lindblad, Staffa ...
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Lysholm, Jörgen
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Rantapää-Dahlqvi ...
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Saxne, Tore
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van Vollenhoven, ...
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Klareskog, Lars
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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MEDICIN OCH HÄLS ...
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Annals of the Rh ...
- Av lärosätet
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Uppsala universitet
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Umeå universitet
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Lunds universitet
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Karolinska Institutet
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Linköpings universitet