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A tool for neutroph...
A tool for neutrophil guided dose adaptation in chemotherapy
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- Wallin, Johan E. (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Pharmacometrics
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- Friberg, Lena E. (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Pharmacometrics
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- Karlsson, Mats O. (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Pharmacometrics
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: Computer Methods and Programs in Biomedicine. - : Elsevier BV. - 0169-2607 .- 1872-7565. ; 93:3, s. 283-291
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Abstract
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- Chemotherapy dosing in anticancer treatment is a balancing act between achieving concentrations that are effective towards the malignancy and that result in acceptable side-effects. Neutropenia is one major side-effect of many antitumor agents, and is related to an increased risk of infection. A model capable of describing the time-course of myelosuppression from administered drug could be used in individual dose selection. In this paper we describe the transfer of a previously developed semi-mechanistic model for myelosuppression from NONMEM to a dosing tool in MS Excel, with etoposide as an example. The tool proved capable to solve a differential equation system describing the pharmacokinetics and pharmacodynamics, with estimation performance comparable to NONMEM. In the dosing tool the user provides neutrophil measures from a previous treatment course and request for the dose that results in a desired nadir in the upcoming course through a Bayesian estimation procedure.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- dose adaptation
- myelosuppression
- pharmacodynamics
- biomarker
- Biopharmacy
- Biofarmaci
- Pharmaceutical pharmacology
- Farmaceutisk farmakologi
- Pharmacokinetics and Drug Therapy
- Farmakokinetik och läkemedelsterapi
Publication and Content Type
- ref (subject category)
- art (subject category)
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