Sökning: hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Medicinska och farmaceutiska grundvetenskaper) hsv:(Farmaceutiska vetenskaper)
> (2000-2009)
> (2005) >
Study of the non-co...
Study of the non-covalent interaction between amyloid-beta-peptide and melatonin using electrospray ionization mass spectrometry
-
- Bazoti, Fotini N (författare)
- GAIA Research Center, The Goulandris Natural History Museum and Department of Pharmacy, Laboratory of Instrumental Analysis, University of Patras, Greece
-
- Tsarbopoulos, Anthony (författare)
- GAIA Research Center, The Goulandris Natural History Museum and Department of Pharmacy, Laboratory of Instrumental Analysis, University of Patras, Greece
-
- Markides, Karin (författare)
- Uppsala universitet,Analytisk kemi,Kemiska institutionen
-
visa fler...
-
- Bergquist, Jonas (författare)
- Uppsala universitet,Analytisk kemi,Kemiska institutionen
-
visa färre...
-
(creator_code:org_t)
- 2005
- 2005
- Engelska.
-
Ingår i: Journal of Mass Spectrometry. - : Wiley. - 1076-5174 .- 1096-9888. ; 40:2, s. 182-192:40, s. 182-192
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Oxidative stress and unregulated immune response are believed to play a key role in the processes inherent to Alzheimer's disease (AD). The fact that free radicals can result in neurodegeneration suggests that actions against reactive oxygen species may be beneficial in treating and preventing AD. In the light of the suggested link between oxidative stress and AD, it is proposed that antioxidants and, even more, endogenous antioxidants may offer a therapeutic regime for protection against the risk of this disease. For this reason, the formation of non-covalent complexes between amyloid-beta-peptide (A beta) or its oxidized forms and melatonin was studied by quadrupole and Fourier transform ion cyclotron resonance electrospray ionization mass spectrometry. The stability of the non-covalent complex was examined under several experimental conditions, such as orifice voltage, pH, presence of organic modifier, concentration and time. Two different digestion protocols combined with mass spectrometric analysis of the resulting peptide fragments were employed in order to locate the binding site of melatonin in A beta.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- Alzheimer's disease
- amyloid-beta-peptide
- melatonin
- non-covalent complexes
- electrospray ionization mass spectrometry
- Chemistry
- Kemi
- PHARMACY
- FARMACI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas