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FältnamnIndikatorerMetadata
00006913naa a2200577 4500
001oai:DiVA.org:liu-153878
003SwePub
008190115s2019 | |||||||||||000 ||eng|
024a urn:nbn:se:liu:diva-1538782 urn
024a https://doi.org/10.1007/s40256-018-0305-02 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Lapostolle, Frédéricu UF Recherche-Enseignement-Qualité, Université Paris, Hôpital Avicenne, Bobigny, France.4 aut
2451 0a Morphine and Ticagrelor Interaction in Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction :b ATLANTIC-Morphine
264 1a Auckland, New Zealand :b Adis International Ltd.c 2019
338 a print2 rdacarrier
520 a BACKGROUND: Morphine adversely impacts the action of oral adenosine diphosphate (ADP)-receptor blockers in ST-segment elevation myocardial infarction (STEMI) patients, and is possibly associated with differing patient characteristics. This retrospective analysis investigated whether interaction between morphine use and pre-percutaneous coronary intervention (pre-PCI) ST-segment elevation resolution in STEMI patients in the ATLANTIC study was associated with differences in patient characteristics and management.METHODS: ATLANTIC was an international, multicenter, randomized study of treatment in the acute ambulance/hospital setting where STEMI patients received ticagrelor 180 mg ± morphine. Patient characteristics, cardiovascular history, risk factors, management, and outcomes were recorded.RESULTS: Opioids (97.6% morphine) were used in 921 out of 1862 patients (49.5%). There were no significant differences in age, sex or cardiovascular history, but more morphine-treated patients had anterior myocardial infarction and left-main disease. Time from chest pain to electrocardiogram and ticagrelor loading was shorter with morphine (both p = 0.01) but not total ischemic time. Morphine-treated patients more frequently received glycoprotein IIb/IIIa inhibitors (p = 0.002), thromboaspiration and stent implantation (both p < 0.001). No significant difference between the two groups was found regarding pre-PCI ≥ 70% ST-segment elevation resolution, death, myocardial infarction, stroke, urgent revascularization and definitive acute stent thrombosis. More morphine-treated patients had an absence of pre-PCI Thrombolysis in Myocardial Infarction (TIMI) 3 flow (85.8% vs. 79.7%; p = 0.001) and more had TIMI major bleeding (1.1% vs. 0.1%; p = 0.02).CONCLUSIONS: Morphine-treatment was associated with increased GP IIb/IIIa inhibitor use, less pre-PCI TIMI 3 flow, and more bleeding. Judicious morphine use is advised with non-opioid analgesics preferred for non-severe acute pain.TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT01347580.
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
700a Van't Hof, Arnoud Wu Department of Cardiology, Isala Clinics, Zwolle, The Netherlands, Maastricht University Medical Center, Maastricht, The Netherlands4 aut
700a Hamm, Christian Wu Department of Cardiology, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany4 aut
700a Stibbe, Olivieru Service Médical d'Urgence, Brigade de Sapeurs-Pompiers de Paris, Paris, France4 aut
700a Ecollan, Patricku Sorbonne Université, ACTION Study Group, Hôpital Pitié-Salpêtrière , Paris, France4 aut
700a Collet, Jean-Philippeu Sorbonne Université, ACTION Study Group, Hôpital Pitié-Salpêtrière , Paris, France4 aut
700a Silvain, Johanneu Sorbonne Université, ACTION Study Group, Hôpital Pitié-Salpêtrière , Paris, France4 aut
700a Lassen, Jens Flenstedu Department of Cardiology B, Aarhus University Hospital, Skejby, Aarhus N, Denmark4 aut
700a Heutz, Wim M J Mu Regionale Ambulance Voor ziening Gelderland-Midden, Arnhem, The Netherlands4 aut
700a Bolognese, Leonardou Cardiovascular and Neurological Department, Azienda Ospedaliera Arezzo, Arezzo, Italy4 aut
700a Cantor, Warren Ju Southlake Regional Health Centre, University of Toronto, Newmarket, ON, Canada4 aut
700a Cequier, Angelu Heart Disease Institute, Hospital Universitario de Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain4 aut
700a Chettibi, Mohamedu Centre Hospito-universitaire Frantz Fanon, Blida, Algeria4 aut
700a Goodman, Shaun Gu Division of Cardiology, Canadian Heart Research Centre, St Michael's Hospital, University of Toronto, Toronto, Canada4 aut
700a Hammett, Christopher Ju Department of Cardiology, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia4 aut
700a Huber, Kurtu 3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminenhospital, Sigmund Freud University, Medical School, Vienna, Austria4 aut
700a Janzon, Magnusu Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US4 aut0 (Swepub:liu)magja75
700a Merkely, Bélau Heart and Vascular Center, Semmelweis University, Budapest, Hungary4 aut
700a Storey, Robert Fu Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK4 aut
700a Ten Berg, Juru Department of Cardiology, St Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands4 aut
700a Zeymer, Uweu Klinikum Ludwigshafen and Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen, Germany4 aut
700a Licour, Murielu AstraZeneca, Rueil Malmaison, France4 aut
700a Tsatsaris, Anneu AstraZeneca, Rueil Malmaison, France4 aut
700a Montalescot, Gillesu Sorbonne Université, ACTION Study Group, Hôpital Pitié-Salpêtrière (AP-HP), 47 boul de l'Hôpital, Paris, France4 aut
710a UF Recherche-Enseignement-Qualité, Université Paris, Hôpital Avicenne, Bobigny, France.b Department of Cardiology, Isala Clinics, Zwolle, The Netherlands, Maastricht University Medical Center, Maastricht, The Netherlands4 org
773t American Journal of Cardiovascular Drugsd Auckland, New Zealand : Adis International Ltd.g 19, s. 173-183q 19<173-183x 1175-3277x 1179-187X
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-153878x lärosäteslänky Till lärosätets (liu) databas
8564 8u https://doi.org/10.1007/s40256-018-0305-0

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