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00005024naa a2200433 4500
008150603s2016 | |||||||||||000 ||eng|
024a urn:nbn:se:oru:diva-448222 urn
024a https://doi.org/10.1136/gutjnl-2014-3090072 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1339346442 URI
040 a (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Kantor, Elizabeth D.u Department of Epidemiology, Harvard School of Public Health, Boston, USA4 aut
2451 0a Adolescent body mass index and erythrocyte sedimentation rate in relation to colorectal cancer risk
264 1a London, United Kingdom :b BMJ Publishing Group,c 2016
338 a print2 rdacarrier
500 a Funding Agencies:National Cancer Institute T32 CA 009001Harvard School of Public HealthÖrebro University Strategic FundingUK Economic and Social Research Council (ESRC) RES-596-28-0001  ES/JO19119/1
506 a gratis
520 a Objective: Adult obesity and inflammation have been associated with risk of colorectal cancer (CRC); however, less is known about how adolescent body mass index (BMI) and inflammation, as measured by erythrocyte sedimentation rate (ESR), relate to CRC risk. We sought to evaluate these associations in a cohort of 239 658 Swedish men who underwent compulsory military enlistment examinations in late adolescence (ages 16-20 years).Design: At the time of the conscription assessment (1969-1976), height and weight were measured and ESR was assayed. By linkage to the national cancer registry, these conscripts were followed for CRC through 1 January 2010. Over an average of 35 years of follow-up, 885 cases of CRC occurred, including 501 colon cancers and 384 rectal cancers. Cox regression was used to estimate adjusted HRs and corresponding 95% CIs.Results: Compared with normal weight (BMI 18.5 to <25 kg/m(2)) in late adolescence, upper overweight (BMI 27.5 to <30 kg/m(2)) was associated with a 2.08-fold higher risk of CRC (95% CI 1.40 to 3.07) and obesity (BMI 30+ kg/m(2)) was associated with a 2.38-fold higher risk of CRC (95% CI 1.51 to 3.76) (p-trend: <0.001). Male adolescents with ESR (15+ mm/h) had a 63% higher risk of CRC (HR 1.63; 95% CI 1.08 to 2.45) than those with low ESR (<10 mm/h) (p-trend: 0.006). Associations did not significantly differ by anatomic site.Conclusions: Late-adolescent BMI and inflammation, as measured by ESR, may be independently associated with future CRC risk. Further research is needed to better understand how early-life exposures relate to CRC.
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
700a Udumyan, Ruzan,d 1971-u Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics4 aut0 (Swepub:oru)run
700a Signorello, Lisa B.u Department of Epidemiology, Harvard School of Public Health, Boston, USA4 aut
700a Giovannucci, Edward L.u Department of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Nutrition, Harvard School of Public Health, Boston, USA; Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, USA4 aut
700a Montgomery, Scott,d 1961-u Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Research Department of Epidemiology and Public Health, University College London, London, United Kingdom; Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Clinical Epidemiology and Biostatistics4 aut0 (Swepub:oru)smy
700a Fall, Katja,d 1971-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Epidemiology, Harvard School of Public Health, Boston, USA; Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Clinical Epidemiology and Biostatistics4 aut0 (Swepub:oru)kafl
710a Department of Epidemiology, Harvard School of Public Health, Boston, USAb Institutionen för medicinska vetenskaper4 org
773t Gutd London, United Kingdom : BMJ Publishing Groupg 65:8, s. 1289-1295q 65:8<1289-1295x 0017-5749x 1468-3288
856u https://europepmc.org/articles/pmc4674372?pdf=render
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-44822x lärosäteslänky Till lärosätets (oru) databas
8564 8u https://doi.org/10.1136/gutjnl-2014-309007
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:133934644

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