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Spirometric phenotypes from early childhood to young adulthood : a Chronic Airway Disease Early Stratification study

Wang, Gang (författare)
Dept of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Sichuan, China; Dept of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden
Hallberg, Jenny (författare)
Karolinska Institutet
Charalampopoulos, Dimitrios (författare)
MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
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Sanahuja, Maribel Casas (författare)
ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Breyer-Kohansal, Robab (författare)
Ludwig Boltzmann Institute for Lung Health, Vienna, Austria
Langhammer, Arnulf (författare)
Dept of Public Health and Nursing, Faculty of Medicine and Health Sciences, HUNT Research Centre, Norwegian University of Science and Technology (NTNU), Levanger, Norway
Granell, Raquel (författare)
MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
Vonk, Judith M. (författare)
Dept of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, Netherlands
Mian, Annemiek (författare)
The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Division of Respiratory Medicine and Allergology, and Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
Olvera, Núria (författare)
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Institut d’investigacions biomediques August Pi I Sunyer, Barcelona, Spain
Laustsen, Lisbeth Mølgaard (författare)
Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark
Rönmark, Eva (författare)
Umeå universitet,Avdelningen för hållbar hälsa
Abellan, Alicia (författare)
Karolinska Institutet
Agusti, Alvar (författare)
Institut d’investigacions biomediques August Pi I Sunyer, Barcelona, Spain; Respiratory Institute, Hospital Clinic, Univ. Barcelona, Barcelona, Spain; CIBERESP (ISCiii), Barcelona, Spain
Arshad, Syed Hasan (författare)
David Hide Asthma and Allergy Research Centre, Newport, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
Bergström, Anna (författare)
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden
Boezen, H. Marike (författare)
Dept of Epidemiology, University Medical Center Groningen, Groningen, Netherlands
Breyer, Marie-Kathrin (författare)
Ludwig Boltzmann Institute for Lung Health, Vienna, Austria
Burghuber, Otto (författare)
Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; Faculty of Medicine, Sigmund Freud University, Vienna, Austria
Bolund, Anneli Clea (författare)
Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark
Custovic, Adnan (författare)
National Heart and Lung Institute, Imperial College London, London, United Kingdom
Devereux, Graham (författare)
Liverpool School of Tropical Medicine, Liverpool, United Kingdom
Donaldson, Gavin C. (författare)
National Heart and Lung Institute, Imperial College London, London, United Kingdom
Duijts, Liesbeth (författare)
The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Division of Respiratory Medicine and Allergology, and Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Division of Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
Esplugues, Ana (författare)
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Nursing Department, Faculty of Nursing and Chiropody, Universitat de València, Valencia, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO−Universitat Jaume I−Universitat de València, Valencia, Spain
Faner, Rosa (författare)
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Ballester, Ferran (författare)
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Nursing Department, Faculty of Nursing and Chiropody, Universitat de València, Valencia, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO−Universitat Jaume I−Universitat de València, Valencia, Spain
Garcia-Aymerich, Judith (författare)
ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain
Gehring, Ulrike (författare)
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands
Haider, Sadia (författare)
National Heart and Lung Institute, Imperial College London, London, United Kingdom
Hartl, Sylvia (författare)
Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; Faculty of Medicine, Sigmund Freud University, Vienna, Austria
Backman, Helena (författare)
Umeå universitet,Avdelningen för hållbar hälsa
Holloway, John W. (författare)
NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
Koppelman, Gerard H. (författare)
University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, Netherlands; Dept of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, Beatrix Children’s Hospital, University of Groningen, Groningen, Netherlands
Lertxundi, Aitana (författare)
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Dept of Preventive Medicine and Public Health, Faculty of Medicine, University of the Basque Country (UPV/EHU), Leioa, Spain; BIODONOSTIA Health Research Institute, Donostia-San Sebastian, Spain
Holmen, Turid Lingaas (författare)
Dept of Public Health and General Practice, HUNT Research Center, NTNU, Levanger, Norway
Lowe, Lesley (författare)
Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, NIHR, Manchester, United Kingdom; Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom
Mensink-Bout, Sara M. (författare)
The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
Murray, Clare S. (författare)
Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, NIHR, Manchester, United Kingdom; Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom
Roberts, Graham (författare)
David Hide Asthma and Allergy Research Centre, Newport, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
Hedman, Linnea, 1979- (författare)
Umeå universitet,Avdelningen för hållbar hälsa
Schlünssen, Vivi (författare)
Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark
Sigsgaard, Torben (författare)
Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark
Simpson, Angela (författare)
Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, NIHR, Manchester, United Kingdom; Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom
Sunyer, Jordi (författare)
ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; IMIM-Parc Salut Mar, Barcelona, Spain
Torrent, Maties (författare)
ib-salut, Area de Salut de Menorca, Menorca, Spain
Turner, Stephen (författare)
Royal Aberdeen Children’s Hospital NHS Grampian, Aberdeen, United Kingdom
Van den Berge, Maarten (författare)
University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, Netherlands; Dept of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Vermeulen, Roel C.H. (författare)
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands
Vikjord, Sigrid Anna Aalberg (författare)
Dept of Public Health and Nursing, Faculty of Medicine and Health Sciences, HUNT Research Centre, Norwegian University of Science and Technology (NTNU), Levanger, Norway; Dept of Medicine and Rehabilitation, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway
Wedzicha, Jadwiga A. (författare)
National Heart and Lung Institute, Imperial College London, London, United Kingdom
van der Zee, Anke H. Maitland (författare)
Dept of Respiratory Medicine, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, Netherlands; Pediatric Respiratory Medicine, Emma Children’s Hospital, Amsterdam UMC, Amsterdam, Netherlands
Melén, Erik (författare)
Karolinska Institutet
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 (creator_code:org_t)
ERS Publications, 2021
2021
Engelska.
Ingår i: ERJ Open Research. - : ERS Publications. - 2312-0541. ; 7:4
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts.Methods: We studied 49334 participants from 14 population-based cohorts in different age groups (⩽10, >10–15, >15–20, >20–25 years, and overall, 5–25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV1/FVC z-score ⩾LLN, and FVC z-score Results: The prevalence of obstructive and restrictive phenotypes varied from 3.2–10.9% and 1.8–7.7%, respectively, without clear age trends. A diagnosis of asthma (adjusted odds ratio (aOR=2.55, 95% CI 2.14–3.04), preterm birth (aOR=1.84, 1.27–2.66), maternal smoking during pregnancy (aOR=1.16, 95% CI 1.01–1.35) and family history of asthma (aOR=1.44, 95% CI 1.25–1.66) were associated with a higher prevalence of obstructive, but not restrictive, phenotype across ages (5–25 years). A higher current body mass index (BMI was more often observed in those with the obstructive phenotype but less in those with the restrictive phenotype (aOR=1.05, 95% CI 1.03–1.06 and aOR=0.81, 95% CI 0.78–0.85, per kg·m−2 increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05–1.46).Conclusion: Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskaper -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences (hsv//eng)

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