Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study

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Spirometric phenotypes from early childhood to young adulthood : a Chronic Airway Disease Early Stratification study

Wang, Gang (författare): Dept of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Sichuan, China; Dept of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden

Hallberg, Jenny (författare): Karolinska Institutet

Charalampopoulos, Dimitrios (författare): MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

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Sanahuja, Maribel Casas (författare): ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain

Breyer-Kohansal, Robab (författare): Ludwig Boltzmann Institute for Lung Health, Vienna, Austria

Langhammer, Arnulf (författare): Dept of Public Health and Nursing, Faculty of Medicine and Health Sciences, HUNT Research Centre, Norwegian University of Science and Technology (NTNU), Levanger, Norway

Granell, Raquel (författare): MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

Vonk, Judith M. (författare): Dept of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, Netherlands

Mian, Annemiek (författare): The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Division of Respiratory Medicine and Allergology, and Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

Olvera, Núria (författare): Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Institut d’investigacions biomediques August Pi I Sunyer, Barcelona, Spain

Laustsen, Lisbeth Mølgaard (författare): Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark

Rönmark, Eva (författare): Umeå universitet,Avdelningen för hållbar hälsa

Abellan, Alicia (författare): Karolinska Institutet

Agusti, Alvar (författare): Institut d’investigacions biomediques August Pi I Sunyer, Barcelona, Spain; Respiratory Institute, Hospital Clinic, Univ. Barcelona, Barcelona, Spain; CIBERESP (ISCiii), Barcelona, Spain

Arshad, Syed Hasan (författare): David Hide Asthma and Allergy Research Centre, Newport, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom

Bergström, Anna (författare): Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden

Boezen, H. Marike (författare): Dept of Epidemiology, University Medical Center Groningen, Groningen, Netherlands

Breyer, Marie-Kathrin (författare): Ludwig Boltzmann Institute for Lung Health, Vienna, Austria

Burghuber, Otto (författare): Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; Faculty of Medicine, Sigmund Freud University, Vienna, Austria

Bolund, Anneli Clea (författare): Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark

Custovic, Adnan (författare): National Heart and Lung Institute, Imperial College London, London, United Kingdom

Devereux, Graham (författare): Liverpool School of Tropical Medicine, Liverpool, United Kingdom

Donaldson, Gavin C. (författare): National Heart and Lung Institute, Imperial College London, London, United Kingdom

Duijts, Liesbeth (författare): The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Division of Respiratory Medicine and Allergology, and Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Division of Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

Esplugues, Ana (författare): Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Nursing Department, Faculty of Nursing and Chiropody, Universitat de València, Valencia, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO−Universitat Jaume I−Universitat de València, Valencia, Spain

Faner, Rosa (författare): Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain

Ballester, Ferran (författare): Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Nursing Department, Faculty of Nursing and Chiropody, Universitat de València, Valencia, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO−Universitat Jaume I−Universitat de València, Valencia, Spain

Garcia-Aymerich, Judith (författare): ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain

Gehring, Ulrike (författare): Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands

Haider, Sadia (författare): National Heart and Lung Institute, Imperial College London, London, United Kingdom

Hartl, Sylvia (författare): Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; Faculty of Medicine, Sigmund Freud University, Vienna, Austria

Backman, Helena (författare): Umeå universitet,Avdelningen för hållbar hälsa

Holloway, John W. (författare): NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom

Koppelman, Gerard H. (författare): University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, Netherlands; Dept of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, Beatrix Children’s Hospital, University of Groningen, Groningen, Netherlands

Lertxundi, Aitana (författare): Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Dept of Preventive Medicine and Public Health, Faculty of Medicine, University of the Basque Country (UPV/EHU), Leioa, Spain; BIODONOSTIA Health Research Institute, Donostia-San Sebastian, Spain

Holmen, Turid Lingaas (författare): Dept of Public Health and General Practice, HUNT Research Center, NTNU, Levanger, Norway

Lowe, Lesley (författare): Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, NIHR, Manchester, United Kingdom; Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom

Mensink-Bout, Sara M. (författare): The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

Murray, Clare S. (författare): Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, NIHR, Manchester, United Kingdom; Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom

Roberts, Graham (författare): David Hide Asthma and Allergy Research Centre, Newport, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom

Hedman, Linnea, 1979- (författare): Umeå universitet,Avdelningen för hållbar hälsa

Schlünssen, Vivi (författare): Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark

Sigsgaard, Torben (författare): Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark

Simpson, Angela (författare): Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, NIHR, Manchester, United Kingdom; Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom

Sunyer, Jordi (författare): ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; IMIM-Parc Salut Mar, Barcelona, Spain

Torrent, Maties (författare): ib-salut, Area de Salut de Menorca, Menorca, Spain

Turner, Stephen (författare): Royal Aberdeen Children’s Hospital NHS Grampian, Aberdeen, United Kingdom

Van den Berge, Maarten (författare): University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, Netherlands; Dept of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, Netherlands

Vermeulen, Roel C.H. (författare): Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands

Vikjord, Sigrid Anna Aalberg (författare): Dept of Public Health and Nursing, Faculty of Medicine and Health Sciences, HUNT Research Centre, Norwegian University of Science and Technology (NTNU), Levanger, Norway; Dept of Medicine and Rehabilitation, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway

Wedzicha, Jadwiga A. (författare): National Heart and Lung Institute, Imperial College London, London, United Kingdom

van der Zee, Anke H. Maitland (författare): Dept of Respiratory Medicine, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, Netherlands; Pediatric Respiratory Medicine, Emma Children’s Hospital, Amsterdam UMC, Amsterdam, Netherlands

Melén, Erik (författare): Karolinska Institutet

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(creator_code:org_t)

2021-09-29
2021
Engelska.
Ingår i: ERJ Open Research. - : ERS Publications. - 2312-0541. ; 7:4

Relaterad länk:: https://doi.org/10.1...; visa fler...; http://umu.diva-port... (primary) (Raw object); https://openres.ersj...; https://doi.org/10.1...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

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Background: The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts.Methods: We studied 49334 participants from 14 population-based cohorts in different age groups (⩽10, >10–15, >15–20, >20–25 years, and overall, 5–25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV1/FVC z-score ⩾LLN, and FVC z-score Results: The prevalence of obstructive and restrictive phenotypes varied from 3.2–10.9% and 1.8–7.7%, respectively, without clear age trends. A diagnosis of asthma (adjusted odds ratio (aOR=2.55, 95% CI 2.14–3.04), preterm birth (aOR=1.84, 1.27–2.66), maternal smoking during pregnancy (aOR=1.16, 95% CI 1.01–1.35) and family history of asthma (aOR=1.44, 95% CI 1.25–1.66) were associated with a higher prevalence of obstructive, but not restrictive, phenotype across ages (5–25 years). A higher current body mass index (BMI was more often observed in those with the obstructive phenotype but less in those with the restrictive phenotype (aOR=1.05, 95% CI 1.03–1.06 and aOR=0.81, 95% CI 0.78–0.85, per kg·m−2 increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05–1.46).Conclusion: Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.

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Av författaren/redakt...: Wang, Gang; Hallberg, Jenny; Charalampopoulos ...; Sanahuja, Maribe ...; Breyer-Kohansal, ...; Langhammer, Arnu ...; visa fler...; Granell, Raquel; Vonk, Judith M.; Mian, Annemiek; Olvera, Núria; Laustsen, Lisbet ...; Rönmark, Eva; Abellan, Alicia; Agusti, Alvar; Arshad, Syed Has ...; Bergström, Anna; Boezen, H. Marik ...; Breyer, Marie-Ka ...; Burghuber, Otto; Bolund, Anneli C ...; Custovic, Adnan; Devereux, Graham; Donaldson, Gavin ...; Duijts, Liesbeth; Esplugues, Ana; Faner, Rosa; Ballester, Ferra ...; Garcia-Aymerich, ...; Gehring, Ulrike; Haider, Sadia; Hartl, Sylvia; Backman, Helena; Holloway, John W ...; Koppelman, Gerar ...; Lertxundi, Aitan ...; Holmen, Turid Li ...; Lowe, Lesley; Mensink-Bout, Sa ...; Murray, Clare S.; Roberts, Graham; Hedman, Linnea, ...; Schlünssen, Vivi; Sigsgaard, Torbe ...; Simpson, Angela; Sunyer, Jordi; Torrent, Maties; Turner, Stephen; Van den Berge, M ...; Vermeulen, Roel ...; Vikjord, Sigrid ...; Wedzicha, Jadwig ...; van der Zee, Ank ...; Melén, Erik; visa färre...

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Spirometric phenotypes from early childhood to young adulthood : a Chronic Airway Disease Early Stratification study

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