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Sökning: onr:"swepub:oai:DiVA.org:umu-199481" > Associations of dep...

Associations of depression and regional brain structure across the adult lifespan : Pooled analyses of six population-based and two clinical cohort studies in the European Lifebrain consortium

Binnewies, Julia (författare)
Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, Netherlands
Nawijn, Laura (författare)
Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, Netherlands
Brandmaier, Andreas M. (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Department of Psychology, MSB Medical School Berlin, Berlin, Germany
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Baaré, William F.C. (författare)
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital – Amager and Hvidovre, Copenhagen, Denmark
Bartrés-Faz, David (författare)
Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona and Institut de Neurociències, Universitat de Barcelona, Spain
Drevon, Christian A. (författare)
Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo & Vitas Ltd, Oslo Science Park, Oslo, Norway
Düzel, Sandra (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany
Fjell, Anders M. (författare)
Center for Lifespan Changes in Brain and Cognition, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Norway
Han, Laura K.M. (författare)
Centre for Youth Mental Health, The University of Melbourne, VIC, Parkville, Australia
Knights, Ethan (författare)
MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom
Lindenberger, Ulman (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany
Milaneschi, Yuri (författare)
Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, Netherlands
Mowinckel, Athanasia M. (författare)
Center for Lifespan Changes in Brain and Cognition, University of Oslo, Norway
Nyberg, Lars, 1966- (författare)
Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI)
Plachti, Anna (författare)
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital – Amager and Hvidovre, Copenhagen, Denmark
Madsen, Kathrine Skak (författare)
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital – Amager and Hvidovre, Copenhagen, Denmark; Radiography, Department of Technology, University College Copenhagen, Copenhagen, Denmark
Solé-Padullés, Cristina (författare)
Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona and Institut de Neurociències, Universitat de Barcelona, Spain
Suri, Sana (författare)
Wellcome Centre for Integrative Neuroimaging, University of Oxford, United Kingdom; Department of Psychiatry, University of Oxford, United Kingdom
Walhovd, Kristine B. (författare)
Center for Lifespan Changes in Brain and Cognition, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Norway
Zsoldos, Enikő (författare)
Wellcome Centre for Integrative Neuroimaging, University of Oxford, United Kingdom; Department of Psychiatry, University of Oxford, United Kingdom
Ebmeier, Klaus P. (författare)
Department of Psychiatry, University of Oxford, United Kingdom
Penninx, Brenda W.J.H. (författare)
Amsterdam UMC Location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, Netherlands
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 (creator_code:org_t)
Elsevier, 2022
2022
Engelska.
Ingår i: NeuroImage. - : Elsevier. - 0353-8842 .- 2213-1582. ; 36
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Objective: Major depressive disorder has been associated with lower prefrontal thickness and hippocampal volume, but it is unknown whether this association also holds for depressive symptoms in the general population. We investigated associations of depressive symptoms and depression status with brain structures across population-based and patient-control cohorts, and explored whether these associations are similar over the lifespan and across sexes.Methods: We included 3,447 participants aged 18–89 years from six population-based and two clinical patient-control cohorts of the European Lifebrain consortium. Cross-sectional meta-analyses using individual person data were performed for associations of depressive symptoms and depression status with FreeSurfer-derived thickness of bilateral rostral anterior cingulate cortex (rACC) and medial orbitofrontal cortex (mOFC), and hippocampal and total grey matter volume (GMV), separately for population-based and clinical cohorts.Results: Across patient-control cohorts, depressive symptoms and presence of mild-to-severe depression were associated with lower mOFC thickness (rsymptoms = −0.15/ rstatus = −0.22), rACC thickness (rsymptoms = −0.20/ rstatus = −0.25), hippocampal volume (rsymptoms = −0.13/ rstatus = 0.13) and total GMV (rsymptoms = −0.21/ rstatus = −0.25). Effect sizes were slightly larger for presence of moderate-to-severe depression. Associations were similar across age groups and sex. Across population-based cohorts, no associations between depression and brain structures were observed.Conclusions: Fitting with previous meta-analyses, depressive symptoms and depression status were associated with lower mOFC, rACC thickness, and hippocampal and total grey matter volume in clinical patient-control cohorts, although effect sizes were small. The absence of consistent associations in population-based cohorts with mostly mild depressive symptoms, suggests that significantly lower thickness and volume of the studied brain structures are only detectable in clinical populations with more severe depressive symptoms.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Brain structure
Depressive symptoms
Grey matter
Lifespan
Meta-analysis
Neuroimaging

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