Assisted assembly : how to improve a de novo genome assembly by using related species

• We describe a new assembly algorithm, where a genome assembly with low sequence coverage, either throughout the genome or locally, due to cloning bias, is considerably improved through an assisting process via a related genome. We show that the information provided by aligning the whole-genome shotgun reads of the target against a reference genome can be used to substantially improve the quality of the resulting assembly.

Ämnesord

NATURAL SCIENCES  -- Biological Sciences (hsv//eng)

NATURVETENSKAP  -- Biologiska vetenskaper (hsv//swe)

Nyckelord

Biology

Biologi

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)