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Sökning: onr:"swepub:oai:gup.ub.gu.se/291090" > Validation of Plasm...

Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort.

Westwood, Sarah (författare)
Department of Psychiatry, University of Oxford, UK
Baird, Alison L (författare)
Department of Psychiatry, University of Oxford, UK
Anand, Sneha N (författare)
Department of Psychiatry, University of Oxford, UK
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Nevado-Holgado, Alejo J (författare)
Department of Psychiatry, University of Oxford, UK
Kormilitzin, Andrey (författare)
Department of Psychiatry, University of Oxford, UK
Shi, Liu (författare)
Department of Psychiatry, University of Oxford, UK
Hye, Abdul (författare)
Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK
Ashton, Nicholas J. (författare)
Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Morgan, Angharad R (författare)
Dementia Research Institute Cardiff, Cardiff University, Cardiff, UK
Bos, Isabelle (författare)
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands
Vos, Stephanie J B (författare)
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands
Baker, Susan (författare)
Janssen R&D, Titusville, NJ, USA
Buckley, Noel J (författare)
Department of Psychiatry, University of Oxford, UK
Ten Kate, Mara (författare)
Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands
Scheltens, Philip (författare)
Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands
Teunissen, Charlotte E (författare)
Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands
Vandenberghe, Rik (författare)
University Hospital Leuven, Leuven, Belgium
Gabel, Silvy (författare)
University Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium
Meersmans, Karen (författare)
University Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium
Engelborghs, Sebastiaan (författare)
Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, University of Antwerp, Antwerp, Belgium; Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium
De Roeck, Ellen E (författare)
Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, University of Antwerp, Antwerp, Belgium; Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium
Sleegers, Kristel (författare)
Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Belgium
Frisoni, Giovanni B (författare)
University of Geneva, Geneva, Switzerland; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Blin, Olivier (författare)
AIX Marseille University, INS, Ap-Hm, Marseille, France
Richardson, Jill C (författare)
Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK
Bordet, Régis (författare)
University of Lille, Inserm, CHU Lille, France
Molinuevo, José L (författare)
Alzheimer's Disease & Other Cognitive Disorders Unit, Hopsital Clínic-IDIBAPS, Barcelona, Spain; Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain
Rami, Lorena (författare)
Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain
Wallin, Anders (författare)
Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Kettunen, Petronella (författare)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
Tsolaki, Magda (författare)
1st Department of Neurology, AHEPA University Hospital, Makedonia, Thessaloniki, Greece
Verhey, Frans (författare)
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands
Lléo, Alberto (författare)
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Sala, Isabel (författare)
Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Popp, Julius (författare)
Karolinska Institutet
Peyratout, Gwendoline (författare)
University Hospital of Lausanne, Lausanne, Switzerland
Martinez-Lage, Pablo (författare)
Geriatric Psychiatry, Department of Mental Health and Psychiatry, Geneva University Hospitals, Geneva, Switzerland
Tainta, Mikel (författare)
CITA-Alzheimer Foundation, San Sebastian, Spain
Johannsen, Peter (författare)
Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Freund-Levi, Yvonne (författare)
Karolinska Institutet
Frölich, Lutz (författare)
Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany
Dobricic, Valerija (författare)
Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany
Legido-Quigley, Cristina (författare)
Kings College London, London, UK; The Systems Medicine Group, Steno Diabetes Center, Gentofte, Denmark
Bertram, Lars (författare)
Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany; Department of Psychology, University of Oslo, Oslo, Norway
Barkhof, Frederik (författare)
Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherland; UCL Institutes of Neurology and Healthcare Engineering, London, UK
Zetterberg, Henrik, 1973 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL, London, UK; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK
Morgan, B Paul (författare)
Dementia Research Institute Cardiff, Cardiff University, Cardiff, UK
Streffer, Johannes (författare)
Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium; UCB, Braine-l'Alleud, Belgium, formerly Janssen R&D, LLC. Beerse, Belgium at the Time of Study Conduct
Visser, Pieter Jelle (författare)
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands; Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands
Lovestone, Simon (författare)
Department of Psychiatry, University of Oxford, UK; Janssen R&D, UK
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IOS Press, 2020
2020
Engelska.
Ingår i: Journal of Alzheimer's disease : JAD. - : IOS Press. - 1875-8908 .- 1387-2877. ; 74:1, s. 213-225
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • We have previously investigated, discovered, and replicated plasma protein biomarkers for use to triage potential trials participants for PET or cerebrospinal fluid measures of Alzheimer's disease (AD) pathology. This study sought to undertake validation of these candidate plasma biomarkers in a large, multi-center sample collection. Targeted plasma analyses of 34 proteins with prior evidence for prediction of in vivo pathology were conducted in up to 1,000 samples from cognitively healthy elderly individuals, people with mild cognitive impairment, and in patients with AD-type dementia, selected from the EMIF-AD catalogue. Proteins were measured using Luminex xMAP, ELISA, and Meso Scale Discovery assays. Seven proteins replicated in their ability to predict in vivo amyloid pathology. These proteins form a biomarker panel that, along with age, could significantly discriminate between individuals with high and low amyloid pathology with an area under the curve of 0.74. The performance of this biomarker panel remained consistent when tested in apolipoprotein E ɛ4 non-carrier individuals only. This blood-based panel is biologically relevant, measurable using practical immunocapture arrays, and could significantly reduce the cost incurred to clinical trials through screen failure.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Alzheimer’s disease
amyloid-β
biomarkers
plasma
proteomics

Publikations- och innehållstyp

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