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Sympathetic and cardiovascular activity during cataplexy in narcolepsy.

Donadio, Vincenzo (författare)
Plazzi, Giuseppe (författare)
Vandi, Stefano (författare)
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Franceschini, Christian (författare)
Karlsson, Tomas, 1957 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Montagna, Pasquale (författare)
Vetrugno, Roberto (författare)
Bugiardini, Enrico (författare)
Mignot, Emmanuel (författare)
Liguori, Rocco (författare)
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2008
2008
Engelska.
Ingår i: Journal of sleep research. - 1365-2869. ; 17:4, s. 458-63
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Autonomic nervous system activity changes have been described during cataplexy as playing a role in triggering it. To confirm these previous findings, we investigated the time course of sympathetic and cardiovascular activities during cataplexy. We made for the first time microneurographic recordings of 10 cataplectic episodes in three patients with hypocretin-deficient narcolepsy. During microneurography, muscle sympathetic nerve activity (MSNA) was recorded simultaneously with heart rate (HR), respiratory movements, arterial finger blood pressure (BP), electroencephalography, electro-oculogram and superficial electromyogram. Results showed no significant autonomic changes before the onset of the cataplectic episodes. Cataplexy was associated with a significant increase in MSNA and BP compared with baseline, whereas HR was markedly decreased. An irregular breathing pattern mainly characterized by apnea typically occurred during the attacks. In conclusion, our findings did not show significant changes in autonomic activity prior to cataplexy onset, ruling out a triggering role of the autonomic system. However, cataplexy was associated with co-activation of sympathetic and parasympathetic autonomic systems, a pattern reminiscent of that reported during the vigilance reaction in animals.

Nyckelord

Blood Pressure
physiology
Cataplexy
physiopathology
Electrocardiography
Electroencephalography
Electromyography
Electrooculography
Heart Rate
physiology
Humans
Intracellular Signaling Peptides and Proteins
deficiency
Male
Narcolepsy
metabolism
physiopathology
Neuropeptides
deficiency
Sympathetic Nervous System
physiopathology
Young Adult

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