SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:lup.lub.lu.se:32597876-d603-45d2-bbe4-3d725d06d78e"
 

Sökning: onr:"swepub:oai:lup.lub.lu.se:32597876-d603-45d2-bbe4-3d725d06d78e" > Pre- and Postnatal ...

  • Wu, Yunjiao (författare)

Pre- and Postnatal Maturation are Important for Fentanyl Exposure in Preterm and Term Newborns : A Pooled Population Pharmacokinetic Study

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Adis International,2022

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:32597876-d603-45d2-bbe4-3d725d06d78e
  • https://lup.lub.lu.se/record/32597876-d603-45d2-bbe4-3d725d06d78eURI
  • https://doi.org/10.1007/s40262-021-01076-0DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background and Objective: Fentanyl is an opioid commonly used to prevent and treat severe pain in neonates; however, its use is off label and mostly based on bodyweight. Given the limited pharmacokinetic information across the entire neonatal age range, we characterized the pharmacokinetics of fentanyl across preterm and term neonates to individualize dosing. Methods: We pooled data from two previous studies on 164 newborns with a median gestational age of 29.0 weeks (range 23.9–42.3), birthweight of 1055 g (range 390–4245), and postnatal age (PNA) of 1 day (range 0–68). In total, 673 plasma samples upon bolus dosing (69 patients; median dose 2.1 μg/kg, median 2 boluses per patient) or continuous infusions (95 patients; median dose 1.1 μg/kg/h for 30 h) with and without boluses were used for population pharmacokinetic modeling in NONMEM® 7.4. Results: Clearance in neonates with birthweight of 2000 and 3000 g was 2.8- and 5.0-fold the clearance in a neonate with birthweight of 1000 g, respectively. Fentanyl clearance at PNA of 7, 14, and 21 days was 2.7-fold, 3.8-fold, and 4.6-fold the clearance at 1 day, respectively. Bodyweight-based dosing resulted in large differences in fentanyl concentrations. Depending on PNA and birthweight, fentanyl concentrations increased slowly after the start of therapy for both intermittent boluses and continuous infusion and reached a maximum concentration at 12–48 h. Conclusions: As both prenatal and postnatal maturation are important for fentanyl exposure, we propose a birthweight- and PNA-based dosage regimen. To provide rapid analgesia in the first 24 h of treatment, additional loading doses need to be considered.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Völler, SwantjeSophia Children's Hospital (författare)
  • Flint, Robert B.Erasmus University Medical Center,Sophia Children's Hospital (författare)
  • Simons, Sinno H.P.Sophia Children's Hospital (författare)
  • Allegaert, KarelCatholic University of Leuven,Erasmus University Medical Center (författare)
  • Fellman, VinetaLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Helsinki,Folkhälsan Research Center(Swepub:lu)pedi-vfe (författare)
  • Knibbe, Catherijne A.J.St. Antonius Hospital,Sophia Children's Hospital (författare)
  • Sophia Children's HospitalErasmus University Medical Center (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical Pharmacokinetics: Adis International61:3, s. 401-4120312-5963

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy