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Sökning: onr:"swepub:oai:lup.lub.lu.se:535ebb05-5470-42db-8abf-0da62ee2fd5f" > Large-scale genome-...

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function

Wild, Philipp S. (författare)
German Centre for Cardiovascular Research,University of Mainz,Prevent Cardiol & Prevent Med, Dept Med 2, Beijing, Peoples R China.;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, Mainz, Germany.;DZHK German Ctr Cardiovasc Res Partner Site Rhine, Mainz, Germany.;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Cardiol, Langen beckstr 1, D-55131 Mainz, Germany.;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, Langen beckstr 1, D-55131 Mainz, Germany.
Felix, Janine F. (författare)
Erasmus University Medical Center,Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Room Na 2906,POB 2040, NL-3000 CA Rotterdam, Netherlands.
Schillert, Arne (författare)
German Centre for Cardiovascular Research,Univ Lubeck, Univ Med Ctr Schleswig Holstein, Inst Med Biometry & Stat, Lubeck, Germany.;DZHK Partner Site Hamburg Kiel Lubeck, Hamburg, Germany.
visa fler...
Teumer, Alexander (författare)
German Centre for Cardiovascular Research,Univ Med Greifswald, Inst Community Med, Greifswald, Germany.;DZHK Partner Site Greifswald, Greifswald, Germany.
Chen, Ming-Huei (författare)
Boston University,Boston Univ, Sch Med, Dept Neurol, Boston, MA 02215 USA.
Leening, Maarten J.G. (författare)
Erasmus University Medical Center,Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Cardiol, Erasmus MC, Rotterdam, Netherlands.
Völker, Uwe (författare)
German Centre for Cardiovascular Research,DZHK Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany.
Großmann, Vera (författare)
University of Mainz,Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, Mainz, Germany.
Brody, Jennifer A (författare)
University of Washington,Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.
Irvin, Marguerite R. (författare)
University of Alabama,Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.
Shah, Sanjiv J. (författare)
Northwestern University,Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.
Pramana, Setia (författare)
Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.,Royal Devon & Exeter Hosp & Univ Exeter, Dept Cardiol, Exeter, Devon, England.,University of Exeter
Lieb, Wolfgang (författare)
University of Kiel,Christian Albrechts Univ Kiel, Inst Epidemiol & Popgen Biobank, Kiel, Germany.
Schmidt, Reinhold (författare)
Medical University of Graz,Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria.
Stanton, Alice V (författare)
Royal College of Surgeons in Ireland,Beaumont Hosp, Blood Pressure Unit, Dublin, Ireland.;Royal Coll Surgeons Ireland, Dept Mol & Cellular Therapeut, Dublin, Ireland.
Malzahn, Dörthe (författare)
University Medical Center Göttingen,Georg August Univ, Univ Med Ctr, Dept Genet Epidemiol, Gottingen, Germany.
Smith, Albert Vernon (författare)
Icelandic Heart Association,University of Iceland,Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
Sundström, Johan (författare)
Uppsala universitet,Uppsala University,Kardiovaskulär epidemiologi
Minelli, Cosetta (författare)
Imperial College London,Imperial Coll London, Natl Heart & Lung Inst NHLI, Populat Hlth & Occupat Dis, London, England.
Ruggiero, Daniela (författare)
Institute of Genetics and Biophysics "A. Buzzati Traverso" (IGB-ABT),Inst Genet & Biophys A Buzzati Traverso, CNR, Naples, Italy.
Lyytikäinen, Leo-Pekka (författare)
University of Tampere,Dept Clin Chem, Fimlab Labs, Tampere, Finland.;Univ Tampere, Fac Med & Life Sci, Dept Clin Chem, Tampere, Finland.
Tiller, Daniel (författare)
Martin-Luther-Universität Halle-Wittenberg,Martin Luther Univ Halle Wittenberg, Inst Med Epidemiol, Biostat & Informat, Halle, Germany.
Smith, Gustav (författare)
Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiovascular Epigenetics,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital,Massachusetts General Hospital,Harvard Medical School,Broad Institute,Lund Univ, Dept Cardiol, Lund, Sweden.;Skane Univ Hosp, Lund, Sweden.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA USA.
Monnereau, Claire (författare)
Erasmus University Medical Center,Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Generat R Study Grp, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Pediat, Erasmus MC, Rotterdam, Netherlands.
Di Tullio, Marco R. (författare)
Columbia University,Columbia Univ, Med Ctr, Dept Med, New York, NY USA.
Musani, Solomon K (författare)
University of Mississippi Medical Center,Univ Mississippi, Med Ctr, Jackson Heart Study, Jackson, MS 39216 USA.
Morrison, Alanna C (författare)
University of Texas,Univ Texas Hlth Sci Ctr Houston, Dept Epidemiol, Human Genet & Environm Sci, Houston, TX USA.
Pers, Tune H. (författare)
Boston Children's Hospital,Broad Institute,Danish Serum Institute, Copenhagen,University of Copenhagen,Broad Inst MIT & Harvard, Med & Populat Genet Program, Cambridge, MA USA.;Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.;Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.;Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.;Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark.
Nilsson, Peter M. (författare)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
Kleber, Marcus E (författare)
Heidelberg University,Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany.
Aragam, Jayashri (författare)
Harvard Medical School,Harvard Med Sch, Boston, MA USA.;Vet Adm Hosp, West Roxbury, Boston, MA USA.
Benjamin, Emelia J (författare)
Natl Heart Lung & Blood Inst, Framingham, MA USA.;Boston Univ Framingham Heart Study, Framingham, MA USA.;Boston Univ, Sch Med & Publ Hlth, Sect Cardiol, Prevent Med & Epidemiol, Boston, MA USA.,Boston University
Bis, Joshua C (författare)
University of Washington,Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.
Bisping, Egbert (författare)
Medical University of Graz,Med Univ Graz, Dept Cariol, Graz, Austria.
Broeckel, Ulrich (författare)
Medical College of Wisconsin,Med Coll Wisconsin, Milwaukee, WI 53226 USA.
Cheng, Susan (författare)
Natl Heart Lung & Blood Inst, Framingham, MA USA.;Boston Univ Framingham Heart Study, Framingham, MA USA.;Harvard Med Sch, Brigham & Womens Hosp, Cardiovasc Div, Boston, MA USA.,Brigham and Women's Hospital / Harvard Medical School
Deckers, Jaap W (författare)
Erasmus University Medical Center,Univ Med Ctr Rotterdam, Dept Cardiol, Erasmus MC, Rotterdam, Netherlands.
Del Greco M, Fabiola (författare)
EURAC Research,British Columbia Children's Hospital,Univ Lubeck, European Acad Bolzano Bozen, Ctr Biomed, Lubeck, Germany.;Univ Lubeck, Affiliated Inst, Lubeck, Germany.
Edelmann, Frank (författare)
Charité - University Medicine Berlin,Charite Univ Med Berlin, Dept Cardiol, Campus Virchow Klinikum, Berlin, Germany.
Fornage, Myriam (författare)
University of Texas,Univ Texas Hlth Sci Ctr, Houston, TX USA.
Franke, Lude (författare)
University of Groningen,Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.
Friedrich, Nele (författare)
University Medicine Greifswald,German Centre for Cardiovascular Research,DZHK Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Inst Clin Chem, Greifswald, Germany.;Univ Med Greifswald, Lab Med, Greifswald, Germany.
Harris, Tamara B (författare)
National Institute on Aging, United States,Natl Inst Aging, NIH, Lab Epidemiol Demog & Biometry, Bethesda, MD USA.
Hofer, Edith (författare)
Medical University of Graz,Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria.;Med Univ Graz, Inst Med Informat, Stat & Documentat, Graz, Austria.
Hofman, Albert (författare)
Erasmus University Medical Center,Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.
Huang, Jie (författare)
Boston VA Research Institute,Brigham and Women's Hospital / Harvard Medical School,Boston VA Res Inst, Boston, MA USA.;Harvard Med Sch, Brigham & Womens Hosp, Div Aging, Boston, MA USA.
Hughes, Alun D. (författare)
University College London,UCL, Inst Cardiovasc Sci, London, England.
Kähönen, Mika (författare)
University of Tampere,Tampere University Hospital,Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.;Univ Tampere, Fac Med & Life Sci, Dept Clin Physiol, Tampere, Finland.
Kruppa, Jochen (författare)
University of Veterinary Medicine Hannover,Univ Lubeck, Univ Med Ctr Schleswig Holstein, Inst Med Biometry & Stat, Lubeck, Germany.;Univ Vet Med, Fdn Inst Vet Med & Genet, Hannover, Germany.
Lackner, Karl J. (författare)
Uppsala universitet,Geriatrik,Univ Med Ctr Mainz, Inst Clin Chem & Lab Med, Mainz, Germany,Universitätsmedizin Mainz
Lannfelt, Lars (författare)
Uppsala University,Univ Med Ctr Mainz, Dept Med 2, Mainz, Germany.,Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL USA.;Univ Miami, Miller Sch Med, McKnight Brain Inst Miller, Miami, FL USA.;Univ Miami, Dept Publ Hlth Sci, Miami, FL USA.;Univ Miami, Dept Human Gen, Miami, FL USA.,Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.;Grp Hlth Res Inst, Grp Hlth Cooperat, Seattle, WA USA.;Seattle Epidemiol Res & Informat Ctr, Dept Vet Affairs Off Res & Dev, Seattle, WA USA.,University of Miami,U.S. Department of Veterans Affairs,University of Washington,Group Health Cooperative
Laskowski, Rafael (författare)
Universitätsmedizin Mainz,Univ Med Ctr Mainz, Dept Med 2, Mainz, Germany.
Launer, Lenore J (författare)
National Institute on Aging, United States,Natl Inst Aging, NIH, Neuroepidemiol Sect, Bethesda, MD USA.
Leosdottir, Margrét (författare)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Dept Cardiol, Lund, Sweden.;Skane Univ Hosp, Malmo, Sweden.
Lin, Honghuang (författare)
Boston University,Natl Heart Lung & Blood Inst, Framingham, MA USA.;Boston Univ Framingham Heart Study, Framingham, MA USA.;Boston Univ, Sch Med, Dept Med, Sect Computat Biomed, Boston, MA 02215 USA.
Lindgren, Cecilia M. (författare)
Harvard University
Loley, Christina (författare)
British Columbia Children's Hospital,Univ Lubeck, Univ Med Ctr Schleswig Holstein, Inst Med Biometry & Stat, Lubeck, Germany.
MacRae, Calum A. (författare)
Harvard University,Brigham and Women's Hospital / Harvard Medical School,MIT, Broad Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Univ, Cambridge, MA 02138 USA.;Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA.
Mascalzoni, Deborah (författare)
British Columbia Children's Hospital,EURAC Research,Univ Lubeck, European Acad Bolzano Bozen, Ctr Biomed, Lubeck, Germany.;Univ Lubeck, Affiliated Inst, Lubeck, Germany.
Mayet, Jamil (författare)
Hammersmith Hospital,Imperial College London,Hammersmith Hosp, Int Ctr Circulatory Hlth, London, England.;NHLI, Imperial Coll London, London, England.
Medenwald, Daniel (författare)
Martin-Luther-Universität Halle-Wittenberg,Martin Luther Univ Halle Wittenberg, Inst Med Epidemiol, Biostat & Informat, Halle, Germany.
Morris, Andrew P (författare)
University of Liverpool,Wellcome Trust Centre for Human Genetics,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.
Müller, Christian (författare)
University Medical Center Hamburg-Eppendorf,Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, Hamburg, Germany.
Müller-Nurasyid, Martina (författare)
German Centre for Cardiovascular Research,Ludwig Maximilians Univ Munchen, Dept Med 1, Munich, Germany.;DZHK Partner Site Munich Heart Alliance, Munich, Germany.;Inst Genet Epidemiol, Helmholtz Zentrum Munchen German Res Ctr Environm, Neuherberg, Germany.,World Orthopaedic Concern
Nappo, Stefania (författare)
Institute of Genetics and Biophysics "A. Buzzati Traverso" (IGB-ABT),Inst Genet & Biophys A Buzzati Traverso, CNR, Naples, Italy.
Nilsson, Peter M. (författare)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
Nuding, Sebastian (författare)
Martin-Luther-Universität Halle-Wittenberg,Univ Clin Halle Saale, Martin Luther Univ Halle Wittenberg, Dept Med 3, Halle, Germany.
Nutile, Teresa (författare)
Institute of Genetics and Biophysics "A. Buzzati Traverso" (IGB-ABT),Inst Genet & Biophys A Buzzati Traverso, CNR, Naples, Italy.
Peters, Annette (författare)
German Centre for Cardiovascular Research,DZHK Partner Site Munich Heart Alliance, Munich, Germany.;Inst Epidemiol II, Helmholtz Zentrum Munchen German Res Ctr Environm, Neuherberg, Germany.
Pfeufer, Arne (författare)
Inst Human Genet, Helmholtz Zentrum Munchen, Neuherberg, Germany.
Pietzner, Diana (författare)
Martin-Luther-Universität Halle-Wittenberg,Martin Luther Univ Halle Wittenberg, Inst Med Epidemiol, Biostat & Informat, Halle, Germany.
Pramstaller, Peter P (författare)
University of Texas,Univ Lubeck, European Acad Bolzano Bozen, Ctr Biomed, Lubeck, Germany.;Univ Lubeck, Affiliated Inst, Lubeck, Germany.;Gen Cent Hosp, Dept Neurol, Bolzano, Italy.;Univ Lubeck, Dept Neurol, Lubeck, Germany.,Univ Penn, Perelman Sch Med, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Div Cardiovasc Med, Philadelphia, PA 19104 USA.,University of Pennsylvania
Raitakari, Olli T (författare)
University of Turku,Turku University Hospital,Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland.;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.
Rice, Kenneth M (författare)
University of Washington
Rivadeneira, Fernando (författare)
Erasmus University Medical Center,Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Generat R Study Grp, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands.
Rotter, Jerome I. (författare)
University of California, Los Angeles,Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA USA.;Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA USA.
Ruohonen, Saku T. (författare)
University of Turku,Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.
Lind, Lars (författare)
Uppsala University,Uppsala universitet,Kardiovaskulär epidemiologi
Samdarshi, Tandaw E. (författare)
University of Mississippi Medical Center,Univ Mississippi, Med Ctr, Div Cardiol, Jackson, MS 39216 USA.
Schmidt, Helena (författare)
Medical University of Graz,Med Univ Graz, Inst Mol Biol & Biochem, Graz, Austria.
Sharp, Andrew S.P. (författare)
University of Exeter,Royal Coll Surgeons Ireland, Dept Mol & Cellular Therapeut, Dublin, Ireland.;Univ Coll Dublin, Sch Med & Med Sci, Dublin, Ireland.,University College Dublin,Royal College of Surgeons in Ireland
Shields, Denis C. (författare)
University College Dublin,Univ Coll Dublin, UCD Conway Inst Biomol & Biomed Res, Dublin, Ireland.;Univ Coll Dublin, Sch Med & Med Sci, Dublin, Ireland.
Sorice, Rossella (författare)
Istituto Neurologico Mediterraneo Neuromed,Inst Genet & Biophys A Buzzati Traverso, CNR, Naples, Italy.;IRCCS Neuromed, Pozzilli, Isernia, Italy.
Sotoodehnia, Nona (författare)
University of Washington,Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Univ Washington, Div Cardiol, Seattle, WA 98195 USA.
Stricker, Bruno H (författare)
Dutch Health Care Inspectorate,Erasmus University Medical Center,Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands.;Inspectorate Hlth Care, Utrecht, Netherlands.
Surendran, Praveen (författare)
University College Dublin,Royal College of Surgeons in Ireland
Thom, Simon (författare)
Imperial College London,Hammersmith Hospital,Hammersmith Hosp, Int Ctr Circulatory Hlth, London, England.;NHLI, Imperial Coll London, London, England.
Töglhofer, Anna M. (författare)
Medical University of Graz
Uitterlinden, André G (författare)
Erasmus University Medical Center,Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands.
Wachter, Rolf (författare)
University Medical Center Göttingen,Georg August Univ, Univ Med Ctr Gottingen, Dept Cardiol & Pneumol, Gottingen, Germany.
Völzke, Henry (författare)
German Centre for Cardiovascular Research,University Medicine Greifswald,Univ Med Greifswald, Inst Community Med, Greifswald, Germany.;DZHK Partner Site Greifswald, Greifswald, Germany.
Ziegler, Andreas (författare)
German Centre for Cardiovascular Research,University of KwaZulu-Natal,Univ Lubeck, Univ Med Ctr Schleswig Holstein, Inst Med Biometry & Stat, Lubeck, Germany.;DZHK Partner Site Hamburg Kiel Lubeck, Hamburg, Germany.;Univ KwaZulu Natal, Sch Math, Stat & Comp Sci, Durban, South Africa.;Univ Lubeck, Zentrum Klin Studien, Lubeck, Germany.
Münzel, Thomas (författare)
Universitätsmedizin Mainz,German Centre for Cardiovascular Research,DZHK German Ctr Cardiovasc Res Partner Site Rhine, Mainz, Germany.;Univ Med Ctr Mainz, Dept Med 2, Mainz, Germany.
März, Winfried (författare)
Medical University of Graz,Heidelberg University,Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany.;Synlab Acad, Synlab Serv GmbH, Mannheim, Germany.;Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria.
Cappola, Thomas P (författare)
University of Pennsylvania
Hirschhorn, Joel N. (författare)
Harvard Medical School,Broad Institute,Boston Children's Hospital,Broad Inst MIT & Harvard, Med & Populat Genet Program, Cambridge, MA USA.;Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.;Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.;Harvard Med Sch, Dept Genet, Boston, MA USA.
Mitchell, Gary F. (författare)
Cardiovascular Engineering Inc.,Cardiovasc Engn Inc, Norwood, MA USA.
Smith, Nicholas L (författare)
U.S. Department of Veterans Affairs,University of Washington,Group Health Cooperative
Fox, Ervin R (författare)
University of Mississippi Medical Center,Univ Mississippi, Med Ctr, Div Cardiol, Jackson, MS 39216 USA.
Dueker, Nicole D. (författare)
University of Miami,Univ Miami, Miller Sch Med, John P Hussman Inst Human Gen, Miami, FL USA.
Jaddoe, Vincent W. V. (författare)
Erasmus University Medical Center,Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.;Generat R Study Grp, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Pediat, Erasmus MC, Rotterdam, Netherlands.
Melander, Olle (författare)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital,Lund Univ, Dept Clin Sci, Malmo, Sweden.;Skane Univ Hosp, Dept Internal Med, Malmo, Sweden.
Russ, Martin (författare)
Helios Amper-klinikum Dachau,Martin-Luther-Universität Halle-Wittenberg,Univ Clin Halle Saale, Martin Luther Univ Halle Wittenberg, Dept Med 3, Halle, Germany.;Helios Amperklin Dachau, Dachau, Germany.
Lehtimäki, Terho (författare)
University of Tampere,Fimlab Laboratories,Dept Clin Chem, Fimlab Labs, Tampere, Finland.;Univ Tampere, Fac Med & Life Sci, Dept Clin Chem, Tampere, Finland.
Ciullo, Marina (författare)
Istituto Neurologico Mediterraneo Neuromed,Institute of Genetics and Biophysics "A. Buzzati Traverso" (IGB-ABT),Inst Genet & Biophys A Buzzati Traverso, CNR, Naples, Italy.;IRCCS Neuromed, Pozzilli, Isernia, Italy.
Hicks, Andrew A (författare)
British Columbia Children's Hospital,EURAC Research,Univ Lubeck, European Acad Bolzano Bozen, Ctr Biomed, Lubeck, Germany.;Univ Lubeck, Affiliated Inst, Lubeck, Germany.
Lind, Lars (författare)
Uppsala University
Gudnason, Vilmundur (författare)
University of Iceland,Icelandic Heart Association,Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
Pieske, Burkert (författare)
Charité - University Medicine Berlin,German Heart Center Berlin,Medical University of Graz,Med Univ Graz, Dept Cariol, Graz, Austria.;Charite Univ Med Berlin, Dept Cardiol, Campus Virchow Klinikum, Berlin, Germany.;German Heart Inst Berlin DHZB, Dept Internal Med Cardiol, Berlin, Germany.
Barron, Anthony J. (författare)
Imperial College London,Hammersmith Hospital,Hammersmith Hosp, Int Ctr Circulatory Hlth, London, England.;NHLI, Imperial Coll London, London, England.
Zweiker, Robert (författare)
Medical University of Graz,Med Univ Graz, Dept Cariol, Graz, Austria.
Schunkert, Heribert (författare)
German Centre for Cardiovascular Research,Technical University of Munich,DZHK Partner Site Munich Heart Alliance, Munich, Germany.;Tech Univ Munich, Deutsches Herzzentrum, Munich, Germany.
Ingelsson, Erik, 1975- (författare)
Uppsala universitet,Uppsala University,Stanford University,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA.
Liu, Kiang (författare)
Northwestern University,Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.
Arnett, Donna K. (författare)
University of Alabama,Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.
Psaty, Bruce M. (författare)
University of Washington,Group Health Cooperative
Blankenberg, Stefan (författare)
University Medical Center Hamburg-Eppendorf,German Centre for Cardiovascular Research,DZHK Partner Site Hamburg Kiel Lubeck, Hamburg, Germany.;Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, Hamburg, Germany.,DZHK Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Dept Internal Med B, Ferdinand Sauerbruch Str, D-17475 Greifswald, Germany.,University Medicine Greifswald
Larson, Martin G. (författare)
Boston University,Boston Univ, Sch Publ Hlth, Biostat Dept, Boston, MA 02215 USA.;Boston Univ, Dept Math & Stat, Boston, MA USA.
Felix, Stephan B (författare)
German Centre for Cardiovascular Research,University Medicine Greifswald
Franco, Oscar H. (författare)
Erasmus University Medical Center,Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.
Zeller, Tanja (författare)
University Medical Center Hamburg-Eppendorf,German Centre for Cardiovascular Research,DZHK Partner Site Hamburg Kiel Lubeck, Hamburg, Germany.;Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, Hamburg, Germany.
Vasan, Ramachandran S. (författare)
Natl Heart Lung & Blood Inst, Framingham, MA USA.;Boston Univ Framingham Heart Study, Framingham, MA USA.;Boston Univ, Sch Med & Publ Hlth, Sect Cardiol, Prevent Med & Epidemiol, Boston, MA USA.;Boston Univ, Sch Med & Framingham Heart Study, Dept Med, Sect Prevent Med & Epidemiol & Cardiol, 801 Massachusetts Ave,Suite 470, Boston, MA 02118 USA.,Boston University
Dörr, Marcus (författare)
University Medicine Greifswald,German Centre for Cardiovascular Research,DZHK Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Dept Internal Med B, Ferdinand Sauerbruch Str, D-17475 Greifswald, Germany.
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 (creator_code:org_t)
The American Society for Clinical Investigation, 2017
2017
Engelska 15 s.
Ingår i: Journal of Clinical Investigation. - : The American Society for Clinical Investigation. - 0021-9738 .- 1558-8238. ; 127:5, s. 1798-1812
  • Tidskriftsartikel (refereegranskat)
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  • BACKGROUND. Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual variability in cardiac structure and function. METHODS. A GWAS meta-analysis of echocardiographic traits was performed, including 46,533 individuals from 30 studies (EchoGen consortium). The analysis included 16 traits of left ventricular (LV) structure, and systolic and diastolic function. RESULTS. The discovery analysis included 21 cohorts for structural and systolic function traits (n = 32,212) and 17 cohorts for diastolic function traits (n = 21,852). Replication was performed in 5 cohorts (n = 14,321) and 6 cohorts (n = 16,308), respectively. Besides 5 previously reported loci, the combined meta-analysis identified 10 additional genome-wide significant SNPs: rs12541595 near MTSS1 and rs10774625 in ATXN2 for LV end-diastolic internal dimension; rs806322 near KCNRG, rs4765663 in CACNA1C, rs6702619 near PALMD, rs7127129 in TMEM16A, rs11207426 near FGGY, rs17608766 in GOSR2, and rs17696696 in CFDP1 for aortic root diameter; and rs12440869 in IQCH for Doppler transmitral A-wave peak velocity. Findings were in part validated in other cohorts and in GWAS of related disease traits. The genetic loci showed associations with putative signaling pathways, and with gene expression in whole blood, monocytes, and myocardial tissue. CONCLUSION. The additional genetic loci identified in this large meta-analysis of cardiac structure and function provide insights into the underlying genetic architecture of cardiac structure and warrant follow-up in future functional studies.

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MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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Wild, Philipp S.
Felix, Janine F.
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Chen, Ming-Huei
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Völker, Uwe
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Shah, Sanjiv J.
Pramana, Setia
Lieb, Wolfgang
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Stanton, Alice V
Malzahn, Dörthe
Smith, Albert Ve ...
Sundström, Johan
Minelli, Cosetta
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Lyytikäinen, Leo ...
Tiller, Daniel
Smith, Gustav
Monnereau, Clair ...
Di Tullio, Marco ...
Musani, Solomon ...
Morrison, Alanna ...
Pers, Tune H.
Nilsson, Peter M ...
Kleber, Marcus E
Aragam, Jayashri
Benjamin, Emelia ...
Bis, Joshua C
Bisping, Egbert
Broeckel, Ulrich
Cheng, Susan
Deckers, Jaap W
Del Greco M, Fab ...
Edelmann, Frank
Fornage, Myriam
Franke, Lude
Friedrich, Nele
Harris, Tamara B
Hofer, Edith
Hofman, Albert
Huang, Jie
Hughes, Alun D.
Kähönen, Mika
Kruppa, Jochen
Lackner, Karl J.
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Lin, Honghuang
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Loley, Christina
MacRae, Calum A.
Mascalzoni, Debo ...
Mayet, Jamil
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Morris, Andrew P
Müller, Christia ...
Müller-Nurasyid, ...
Nappo, Stefania
Nuding, Sebastia ...
Nutile, Teresa
Peters, Annette
Pfeufer, Arne
Pietzner, Diana
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Raitakari, Olli ...
Rice, Kenneth M
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Rotter, Jerome I ...
Ruohonen, Saku T ...
Lind, Lars
Samdarshi, Tanda ...
Schmidt, Helena
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Thom, Simon
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Wachter, Rolf
Völzke, Henry
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Fox, Ervin R
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Russ, Martin
Lehtimäki, Terho
Ciullo, Marina
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Liu, Kiang
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MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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