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Sökning: onr:"swepub:oai:DiVA.org:liu-153878" > Morphine and Ticagr...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006750naa a2200565 4500
001oai:DiVA.org:liu-153878
003SwePub
008190115s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1538782 URI
0247 a https://doi.org/10.1007/s40256-018-0305-02 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lapostolle, Frédéricu UF Recherche-Enseignement-Qualité, Université Paris, Hôpital Avicenne, Bobigny, France.4 aut
2451 0a Morphine and Ticagrelor Interaction in Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction :b ATLANTIC-Morphine
264 c 2018-10-23
264 1a Auckland, New Zealand :b Adis International Ltd.c 2019
338 a print2 rdacarrier
520 a BACKGROUND: Morphine adversely impacts the action of oral adenosine diphosphate (ADP)-receptor blockers in ST-segment elevation myocardial infarction (STEMI) patients, and is possibly associated with differing patient characteristics. This retrospective analysis investigated whether interaction between morphine use and pre-percutaneous coronary intervention (pre-PCI) ST-segment elevation resolution in STEMI patients in the ATLANTIC study was associated with differences in patient characteristics and management.METHODS: ATLANTIC was an international, multicenter, randomized study of treatment in the acute ambulance/hospital setting where STEMI patients received ticagrelor 180 mg ± morphine. Patient characteristics, cardiovascular history, risk factors, management, and outcomes were recorded.RESULTS: Opioids (97.6% morphine) were used in 921 out of 1862 patients (49.5%). There were no significant differences in age, sex or cardiovascular history, but more morphine-treated patients had anterior myocardial infarction and left-main disease. Time from chest pain to electrocardiogram and ticagrelor loading was shorter with morphine (both p = 0.01) but not total ischemic time. Morphine-treated patients more frequently received glycoprotein IIb/IIIa inhibitors (p = 0.002), thromboaspiration and stent implantation (both p < 0.001). No significant difference between the two groups was found regarding pre-PCI ≥ 70% ST-segment elevation resolution, death, myocardial infarction, stroke, urgent revascularization and definitive acute stent thrombosis. More morphine-treated patients had an absence of pre-PCI Thrombolysis in Myocardial Infarction (TIMI) 3 flow (85.8% vs. 79.7%; p = 0.001) and more had TIMI major bleeding (1.1% vs. 0.1%; p = 0.02).CONCLUSIONS: Morphine-treatment was associated with increased GP IIb/IIIa inhibitor use, less pre-PCI TIMI 3 flow, and more bleeding. Judicious morphine use is advised with non-opioid analgesics preferred for non-severe acute pain.TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT01347580.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Van't Hof, Arnoud Wu Department of Cardiology, Isala Clinics, Zwolle, The Netherlands, Maastricht University Medical Center, Maastricht, The Netherlands4 aut
7001 a Hamm, Christian Wu Department of Cardiology, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany4 aut
7001 a Stibbe, Olivieru Service Médical d'Urgence, Brigade de Sapeurs-Pompiers de Paris, Paris, France4 aut
7001 a Ecollan, Patricku Sorbonne Université, ACTION Study Group, Hôpital Pitié-Salpêtrière , Paris, France4 aut
7001 a Collet, Jean-Philippeu Sorbonne Université, ACTION Study Group, Hôpital Pitié-Salpêtrière , Paris, France4 aut
7001 a Silvain, Johanneu Sorbonne Université, ACTION Study Group, Hôpital Pitié-Salpêtrière , Paris, France4 aut
7001 a Lassen, Jens Flenstedu Department of Cardiology B, Aarhus University Hospital, Skejby, Aarhus N, Denmark4 aut
7001 a Heutz, Wim M J Mu Regionale Ambulance Voor ziening Gelderland-Midden, Arnhem, The Netherlands4 aut
7001 a Bolognese, Leonardou Cardiovascular and Neurological Department, Azienda Ospedaliera Arezzo, Arezzo, Italy4 aut
7001 a Cantor, Warren Ju Southlake Regional Health Centre, University of Toronto, Newmarket, ON, Canada4 aut
7001 a Cequier, Angelu Heart Disease Institute, Hospital Universitario de Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain4 aut
7001 a Chettibi, Mohamedu Centre Hospito-universitaire Frantz Fanon, Blida, Algeria4 aut
7001 a Goodman, Shaun Gu Division of Cardiology, Canadian Heart Research Centre, St Michael's Hospital, University of Toronto, Toronto, Canada4 aut
7001 a Hammett, Christopher Ju Department of Cardiology, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia4 aut
7001 a Huber, Kurtu 3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminenhospital, Sigmund Freud University, Medical School, Vienna, Austria4 aut
7001 a Janzon, Magnusu Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US4 aut0 (Swepub:liu)magja75
7001 a Merkely, Bélau Heart and Vascular Center, Semmelweis University, Budapest, Hungary4 aut
7001 a Storey, Robert Fu Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK4 aut
7001 a Ten Berg, Juru Department of Cardiology, St Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands4 aut
7001 a Zeymer, Uweu Klinikum Ludwigshafen and Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen, Germany4 aut
7001 a Licour, Murielu AstraZeneca, Rueil Malmaison, France4 aut
7001 a Tsatsaris, Anneu AstraZeneca, Rueil Malmaison, France4 aut
7001 a Montalescot, Gillesu Sorbonne Université, ACTION Study Group, Hôpital Pitié-Salpêtrière (AP-HP), 47 boul de l'Hôpital, Paris, France4 aut
7102 a UF Recherche-Enseignement-Qualité, Université Paris, Hôpital Avicenne, Bobigny, France.b Department of Cardiology, Isala Clinics, Zwolle, The Netherlands, Maastricht University Medical Center, Maastricht, The Netherlands4 org
7730 t American Journal of Cardiovascular Drugsd Auckland, New Zealand : Adis International Ltd.g 19, s. 173-183q 19<173-183x 1175-3277x 1179-187X
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-153878
8564 8u https://doi.org/10.1007/s40256-018-0305-0

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