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Association Between...
Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals : A Longitudinal Descriptive Cohort Study
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- Reijs, Babette L R (författare)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands
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- Vos, Stephanie J B (författare)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands
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- Soininen, Hilkka (författare)
- Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland
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- Lötjonen, Jyrki (författare)
- VTT Technical Research Centre of Finland, Tampere, Finland; Combinostics Oy, Tampere, Finland,VTT Technical Research Center of Finland, Espoo
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- Koikkalainen, Juha (författare)
- VTT Technical Research Centre of Finland, Tampere, Finland; Combinostics Oy, Tampere, Finland,VTT Technical Research Center of Finland, Espoo
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- Pikkarainen, Maria (författare)
- Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
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- Hall, Anette (författare)
- Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland
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- Vanninen, Ritva (författare)
- Department of Radiology, Kuopio University Hospital, Kuopio, Finland
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- Liu, Yawu (författare)
- Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland; Department of Radiology, Kuopio University Hospital, Kuopio, Finland
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- Herukka, Sanna-Kaisa (författare)
- Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland
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- Freund-Levi, Yvonne (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of NVS, Section of Clinical Geriatrics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
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- Frisoni, Giovanni B (författare)
- LENITEM, IRCCS Fatebenefratelli, Brescia,Centro San Giovanni di Dio Fatebenefratelli
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- Frölich, Lutz (författare)
- Department of Geriatric Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Germany
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- Nobili, Flavio (författare)
- Department of Neuroscience (DINOGMI), Clinical Neurology, University of Genoa and IRCCS AOU San Martino-IST Genoa, Italy,Ospedale Policlinico San Martino
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- Rikkert, Marcel Olde (författare)
- Department of Geriatrics, Radboud University Medical Centre, Nijmegen, The Netherlands
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- Spiru, Luiza (författare)
- Carol Davila’ University of Medicine and Pharmacy, Bucharest, Romania
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- Tsolaki, Magda (författare)
- Aristotle University of Thessaloniki, Memory and Dementia Centre, G. Papanicolaore General Hospital, Thessaloniki, Greece
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- Wallin, Åsa K. (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Scheltens, Philip (författare)
- Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Verhey, Frans (författare)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands
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- Visser, Pieter Jelle (författare)
- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands; Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands,Amsterdam UMC - Vrije Universiteit Amsterdam
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(creator_code:org_t)
- IOS Press, 2017
- 2017
- Engelska.
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Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 60:4, s. 1387-1395
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear.OBJECTIVE: To examine the association between later life lifestyle factors and AD biomarkers (i.e., amyloid-β 1-42 (Aβ42) and tau in cerebrospinal fluid (CSF), and hippocampal volume) in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). In addition, to examine the effect of later life lifestyle factors on developing AD-type dementia in individuals with MCI.METHODS: We selected individuals with SCD (n = 111) and MCI (n = 353) from the DESCRIPA and Kuopio Longitudinal MCI studies. CSF Aβ42 and tau concentrations were assessed with ELISA assay and hippocampal volume with multi-atlas segmentation. Lifestyle was assessed by clinical interview at baseline for: social activity, physical activity, cognitive activity, smoking, alcohol consumption, and sleep. We performed logistic and Cox regression analyses adjusted for study site, age, gender, education, and diagnosis. Prediction for AD-type dementia was performed in individuals with MCI only.RESULTS: Later life lifestyle factors were not associated with AD biomarkers or with conversion to AD-type dementia. AD biomarkers were strongly associated with conversion to AD-type dementia, but these relations were not modulated by lifestyle factors. Apolipoprotein E (APOE) genotype did not influence the results.CONCLUSIONS: Later life lifestyle factors had no impact on key AD biomarkers in individuals with SCD and MCI or on conversion to AD-type dementia in MCI.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Alcohol consumption
- Alzheimer’s disease
- amyloid-β (1–42)
- cerebrospinal fluid
- cognitive reserve
- exercise
- hippocampus
- lifestyle
- mild cognitive impairment
- Alcohol consumption
- Alzheimer's disease
- amyloid-β (1-42)
- cerebrospinal fluid
- cognitive reserve
- exercise
- hippocampus
- lifestyle
- mild cognitive impairment
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Reijs, Babette L ...
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Vos, Stephanie J ...
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Soininen, Hilkka
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Lötjonen, Jyrki
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Koikkalainen, Ju ...
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Pikkarainen, Mar ...
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visa fler...
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Hall, Anette
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Vanninen, Ritva
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Liu, Yawu
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Herukka, Sanna-K ...
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Freund-Levi, Yvo ...
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Frisoni, Giovann ...
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Frölich, Lutz
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Nobili, Flavio
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Rikkert, Marcel ...
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Spiru, Luiza
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Tsolaki, Magda
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Wallin, Åsa K.
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Scheltens, Phili ...
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Verhey, Frans
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Visser, Pieter J ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Journal of Alzhe ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet
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Lunds universitet