Sökning: onr:"swepub:oai:DiVA.org:uu-135045" >
Shape analysis of t...
Shape analysis of the neostriatum in subtypes of frontotemporal lobar degeneration : neuroanatomically significant regional morphologic change
-
Looi, Jeffrey Chee Leong (författare)
-
Walterfang, Mark (författare)
-
Styner, Martin (författare)
-
visa fler...
-
Niethammer, Marc (författare)
-
Svensson, Leif Anders (författare)
-
- Lindberg, Olof (författare)
- Karolinska Institutet
-
- Östberg, Per (författare)
- Karolinska Institutet,Uppsala universitet,Logopedi
-
Botes, Lisa (författare)
-
- Örndahl, Eva (författare)
- Karolinska Institutet
-
Chua, Phyllis (författare)
-
Velakoulis, Dennis (författare)
-
Wahlund, Lars-Olof (författare)
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- Engelska.
-
Ingår i: Psychiatry Research. - : Elsevier BV. - 0925-4927 .- 1872-7506 .- 0165-1781. ; 191:2, s. 98-111
- Relaterad länk:
-
https://openresearch...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Frontostriatal circuit mediated cognitive dysfunction has been implicated in frontotemporal lobar degeneration (FTLD) and may differ across subtypes of FTLD. We manually segmented the neostriatum (caudate nucleus and putamen) in FTLD subtypes: behavioral variant frontotemporal dementia, FTD, n=12; semantic dementia, SD, n=13; and progressive non-fluent aphasia, PNFA, n=9); in comparison with controls (n=27). Diagnoses were based on international consensus criteria. Manual bilateral segmentation of the caudate nucleus and putamen was conducted blind to diagnosis by a single analyst, on MRI scans using a standardized protocol. Intracranial volume was calculated via a stereological point counting technique and was used for normalizing the shape analysis. Segmented binaries were analyzed using the Spherical Harmonic (SPHARM) Shape Analysis tools (University of North Carolina) to perform comparisons between FTLD subtypes and controls for global shape difference, local significance maps and mean magnitude maps of shape displacement. Shape analysis revealed that there was significant shape difference between FTLD subtypes and controls, consistent with the predicted frontostriatal dysfunction and of significant magnitude, as measured by displacement maps. These differences were not significant for SD compared to controls; lesser for PNFA compared to controls; whilst FTD showed a more specific pattern in regions relaying fronto- and corticostriatal circuits. Shape analysis shows regional specificity of atrophy, manifest as shape deflation, with a differential between FTLD subtypes, compared to controls.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Looi, Jeffrey Ch ...
-
Walterfang, Mark
-
Styner, Martin
-
Niethammer, Marc
-
Svensson, Leif A ...
-
Lindberg, Olof
-
visa fler...
-
Östberg, Per
-
Botes, Lisa
-
Örndahl, Eva
-
Chua, Phyllis
-
Velakoulis, Denn ...
-
Wahlund, Lars-Ol ...
-
visa färre...
- Artiklar i publikationen
-
Psychiatry Resea ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet