Sökning: onr:"swepub:oai:DiVA.org:uu-165152" >
Risk factors for ne...
Risk factors for new-onset cat sensitization among adults : A population-based international cohort study
-
Olivieri, Mario (författare)
-
Zock, Jan-Paul (författare)
-
Accordini, Simone (författare)
-
visa fler...
-
Heinrich, Joachim (författare)
-
Jarvis, Deborah (författare)
-
Künzli, Nino (författare)
-
Antó, Josep M (författare)
-
- Norbäck, Dan (författare)
- Uppsala universitet,Arbets- och miljömedicin,Eva Vingård
-
Svanes, Cecilie (författare)
-
Verlato, Giuseppe (författare)
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- Engelska.
-
Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 129:2, s. 420-425
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Cat exposure during childhood has been shown to increase the risk of developing cat sensitization, while the effect of cat exposure in adulthood has not yet been established. OBJECTIVE: To evaluate new-onset sensitization to cat in adulthood in relation to changes in cat keeping. METHODS: A total of 6292 European Community Respiratory Health Survey I (ECRHS I) participants aged 20 to 44 years from 28 European centers, who were not sensitized to cat, were reevaluated 9 years later in ECRHS II. Present and past cat ownership and total and specific IgE levels were assessed in both surveys. Allergen-specific sensitization was defined as a specific serum IgE level of 0.35 kU/L or more. RESULTS: A total of 4468 subjects did not have a cat in ECRHS I or ECRHS II, 473 had a cat only at baseline, 651 acquired a cat during the follow-up, and 700 had a cat at both evaluations. Two hundred thirty-one subjects (3.7%) became sensitized to cat. In a 2-level multivariable Poisson regression model, cat acquisition during follow-up was significantly associated with new-onset cat sensitization (relative risk = 1.85, 95% CI 1.23-2.78) when compared with those without a cat at both surveys. Preexisting sensitization to other allergens, a history of asthma, nasal allergies and eczema, and high total IgE level were also significant risk factors for developing cat sensitization, while cat ownership in childhood was a significant protective factor. CONCLUSION: Our data support that acquiring a cat in adulthood nearly doubles the risk of developing cat sensitization. Hence, cat avoidance should be considered in adults, especially in those sensitized to other allergens and reporting a history of allergic diseases.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Olivieri, Mario
-
Zock, Jan-Paul
-
Accordini, Simon ...
-
Heinrich, Joachi ...
-
Jarvis, Deborah
-
Künzli, Nino
-
visa fler...
-
Antó, Josep M
-
Norbäck, Dan
-
Svanes, Cecilie
-
Verlato, Giusepp ...
-
visa färre...
- Artiklar i publikationen
-
Journal of Aller ...
- Av lärosätet
-
Uppsala universitet