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Genetic association...
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
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- Pattaro, Cristian (author)
- University of Lübeck
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Teumer, Alexander (author)
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Gorski, Mathias (author)
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show more...
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Chu, Audrey Y (author)
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Li, Man (author)
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Mijatovic, Vladan (author)
-
Garnaas, Maija (author)
-
Tin, Adrienne (author)
-
Sorice, Rossella (author)
-
Li, Yong (author)
-
Taliun, Daniel (author)
-
Olden, Matthias (author)
-
Foster, Meredith (author)
-
Yang, Qiong (author)
-
Chen, Ming-Huei (author)
-
Pers, Tune H (author)
-
Johnson, Andrew D (author)
-
Ko, Yi-An (author)
-
Fuchsberger, Christian (author)
-
Tayo, Bamidele (author)
-
Nalls, Michael (author)
-
Feitosa, Mary F (author)
-
Isaacs, Aaron (author)
-
Dehghan, Abbas (author)
-
d'Adamo, Pio (author)
-
Adeyemo, Adebowale (author)
-
Dieffenbach, Aida Karina (author)
-
Zonderman, Alan B (author)
-
Nolte, Ilja M (author)
-
van der Most, Peter J (author)
-
Wright, Alan F (author)
-
Shuldiner, Alan R (author)
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Morrison, Alanna C (author)
-
Hofman, Albert (author)
-
Smith, Albert V (author)
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Dreisbach, Albert W (author)
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Franke, Andre (author)
-
Uitterlinden, Andre G (author)
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Metspalu, Andres (author)
-
Tonjes, Anke (author)
-
Lupo, Antonio (author)
-
Robino, Antonietta (author)
-
- Johansson, Åsa (author)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab
-
Demirkan, Ayse (author)
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Kollerits, Barbara (author)
-
Freedman, Barry I (author)
-
Ponte, Belen (author)
-
Oostra, Ben A (author)
-
Paulweber, Bernhard (author)
-
Krämer, Bernhard K (author)
-
Mitchell, Braxton D (author)
-
Buckley, Brendan M (author)
-
Peralta, Carmen A (author)
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Hayward, Caroline (author)
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Helmer, Catherine (author)
-
Rotimi, Charles N (author)
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Shaffer, Christian M (author)
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Müller, Christian (author)
-
- Sala, Cinzia (author)
- Harvard Medical School
-
van Duijn, Cornelia M (author)
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Saint-Pierre, Aude (author)
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Ackermann, Daniel (author)
-
Shriner, Daniel (author)
-
Ruggiero, Daniela (author)
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Toniolo, Daniela (author)
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Lu, Yingchang (author)
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Cusi, Daniele (author)
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Czamara, Darina (author)
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Ellinghaus, David (author)
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Siscovick, David S (author)
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Ruderfer, Douglas (author)
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Gieger, Christian (author)
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Grallert, Harald (author)
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Rochtchina, Elena (author)
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Atkinson, Elizabeth J (author)
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Holliday, Elizabeth G (author)
-
Boerwinkle, Eric (author)
-
Salvi, Erika (author)
-
Bottinger, Erwin P (author)
-
Murgia, Federico (author)
-
Rivadeneira, Fernando (author)
-
Ernst, Florian (author)
-
Kronenberg, Florian (author)
-
Hu, Frank B (author)
-
Navis, Gerjan J (author)
-
Curhan, Gary C (author)
-
Ehret, George B (author)
-
Homuth, Georg (author)
-
Coassin, Stefan (author)
-
Thun, Gian-Andri (author)
-
Pistis, Giorgio (author)
-
Gambaro, Giovanni (author)
-
Malerba, Giovanni (author)
-
Montgomery, Grant W (author)
-
Eiriksdottir, Gudny (author)
-
Jacobs, Gunnar (author)
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Li, Guo (author)
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Wichmann, H-Erich (author)
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Campbell, Harry (author)
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Schmidt, Helena (author)
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Wallaschofski, Henri (author)
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Völzke, Henry (author)
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Brenner, Hermann (author)
-
Kroemer, Heyo K (author)
-
Kramer, Holly (author)
-
Lin, Honghuang (author)
-
Mateo Leach, I (author)
-
Ford, Ian (author)
-
Guessous, Idris (author)
-
Rudan, Igor (author)
-
Prokopenko, Inga (author)
-
Borecki, Ingrid (author)
-
Heid, Iris M (author)
-
Kolcic, Ivana (author)
-
Persico, Ivana (author)
-
Jukema, J Wouter (author)
-
Wilson, James F (author)
-
Felix, Janine F (author)
-
Divers, Jasmin (author)
-
Lambert, Jean-Charles (author)
-
Stafford, Jeanette M (author)
-
Gaspoz, Jean-Michel (author)
-
Smith, Jennifer A (author)
-
Faul, Jessica D (author)
-
Wang, Jie Jin (author)
-
Ding, Jingzhong (author)
-
Hirschhorn, Joel N (author)
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Attia, John (author)
-
Whitfield, John B (author)
-
Chalmers, John (author)
-
Viikari, Jorma (author)
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Coresh, Josef (author)
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Denny, Joshua C (author)
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Karjalainen, Juha (author)
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Fernandes, Jyotika K (author)
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Endlich, Karlhans (author)
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Butterbach, Katja (author)
-
- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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Lohman, Kurt (author)
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Portas, Laura (author)
-
Launer, Lenore J (author)
-
Lyytikäinen, Leo-Pekka (author)
-
Yengo, Loic (author)
-
Franke, Lude (author)
-
Ferrucci, Luigi (author)
-
Rose, Lynda M (author)
-
Kedenko, Lyudmyla (author)
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Rao, Madhumathi (author)
-
Struchalin, Maksim (author)
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Kleber, Marcus E (author)
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Cavalieri, Margherita (author)
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Haun, Margot (author)
-
Cornelis, Marilyn C (author)
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Ciullo, Marina (author)
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Pirastu, Mario (author)
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de Andrade, Mariza (author)
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McEvoy, Mark A (author)
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Woodward, Mark (author)
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Adam, Martin (author)
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Cocca, Massimiliano (author)
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Nauck, Matthias (author)
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Imboden, Medea (author)
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Waldenberger, Melanie (author)
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Pruijm, Menno (author)
-
- Sjögren, M. (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Stumvoll, Michael (author)
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Evans, Michele K (author)
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Sale, Michele M (author)
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Kähönen, Mika (author)
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Boban, Mladen (author)
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Bochud, Murielle (author)
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Rheinberger, Myriam (author)
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Verweij, Niek (author)
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Bouatia-Naji, Nabila (author)
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Martin, Nicholas G (author)
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Hastie, Nick (author)
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Probst-Hensch, Nicole (author)
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Soranzo, Nicole (author)
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Devuyst, Olivier (author)
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Raitakari, Olli (author)
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Gottesman, Omri (author)
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Franco, Oscar H (author)
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Polasek, Ozren (author)
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Gasparini, Paolo (author)
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Munroe, Patricia B (author)
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Ridker, Paul M (author)
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Mitchell, Paul (author)
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Muntner, Paul (author)
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Meisinger, Christa (author)
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Smit, Johannes H (author)
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Kovacs, Peter (author)
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Wild, Philipp S (author)
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Froguel, Philippe (author)
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Rettig, Rainer (author)
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Mägi, Reedik (author)
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Biffar, Reiner (author)
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Schmidt, Reinhold (author)
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Middelberg, Rita P S (author)
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Carroll, Robert J (author)
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Penninx, Brenda W (author)
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Scott, Rodney J (author)
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Katz, Ronit (author)
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Sedaghat, Sanaz (author)
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Wild, Sarah H (author)
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Kardia, Sharon L R (author)
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Ulivi, Sheila (author)
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Hwang, Shih-Jen (author)
-
- Enroth, Stefan (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Gyllensten
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Kloiber, Stefan (author)
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Trompet, Stella (author)
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Stengel, Benedicte (author)
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Hancock, Stephen J (author)
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Turner, Stephen T (author)
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Rosas, Sylvia E (author)
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Stracke, Sylvia (author)
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Harris, Tamara B (author)
-
Zeller, Tanja (author)
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Zemunik, Tatijana (author)
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Lehtimäki, Terho (author)
-
Illig, Thomas (author)
-
Aspelund, Thor (author)
-
Nikopensius, Tiit (author)
-
Esko, Tonu (author)
-
Tanaka, Toshiko (author)
-
- Gyllensten, Ulf (author)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab
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Völker, Uwe (author)
-
Emilsson, Valur (author)
-
Vitart, Veronique (author)
-
Aalto, Ville (author)
-
Gudnason, Vilmundur (author)
-
Chouraki, Vincent (author)
-
Chen, Wei-Min (author)
-
- Igl, Wilmar (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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März, Winfried (author)
-
Koenig, Wolfgang (author)
-
Lieb, Wolfgang (author)
-
Loos, Ruth J F (author)
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Liu, Yongmei (author)
-
Snieder, Harold (author)
-
Pramstaller, Peter P (author)
-
Parsa, Afshin (author)
-
O'Connell, Jeffrey R (author)
-
Susztak, Katalin (author)
-
Hamet, Pavel (author)
-
Tremblay, Johanne (author)
-
- Hedblad, B. (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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Böger, Carsten A (author)
-
Goessling, Wolfram (author)
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Chasman, Daniel I (author)
-
Köttgen, Anna (author)
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Kao, W H Linda (author)
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Fox, Caroline S (author)
-
- Lind, Lars (contributor)
- Uppsala universitet,Kardiovaskulär epidemiologi
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- Fava, C. (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Melander, O. (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Nilsson, P. (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Dahgam, Santosh (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine
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- Nyberg, Fredrik, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine
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- Rosengren, Annika, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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(creator_code:org_t)
- 2016-01-21
- 2016
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
- Related links:
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https://www.nature.c...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://gup.ub.gu.se...
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Abstract
Subject headings
Close
- Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- biological marker
- creatinine
- cystatin C
- deoxyribonuclease I
- morpholino oligonucleotide
- cardiovascular disease
- cells and cell components
- diabetes
- enzyme activity
- genetic analysis
- glucose
- meta-analysis
- metabolism
- physiological response
- adrenal cortex
- adrenal gland
- adult
- Article
- bioinformatics
- chromatin
- controlled study
- creatinine blood level
- diabetes mellitus
- embryo
- embryonic stem cell
- ethnic group
- ethnicity
- gene locus
- gene replication
- genetic association
- genetic susceptibility
- genetic variability
- genotype
- glomerulus filtration rate
- glucose metabolism
- human
- human cell
- hypertension
- kidney cell
- kidney development
- kidney epithelium
- kidney function
- kidney parenchyma
- kidney proximal tubule
- kidney structure
- phenotype
- single nucleotide polymorphism
- chronic kidney failure
- gene expression regulation
- genetic predisposition
- genetics
- genome-wide association study
- meta analysis
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Humans
- Renal Insufficiency, Chronic
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pattaro, Cristia ...
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Teumer, Alexande ...
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Gorski, Mathias
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Chu, Audrey Y
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Li, Man
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Mijatovic, Vlada ...
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show more...
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Garnaas, Maija
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Tin, Adrienne
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Sorice, Rossella
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Li, Yong
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Taliun, Daniel
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Olden, Matthias
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Foster, Meredith
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Yang, Qiong
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Chen, Ming-Huei
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Pers, Tune H
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Johnson, Andrew ...
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Ko, Yi-An
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Fuchsberger, Chr ...
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Tayo, Bamidele
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Nalls, Michael
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Feitosa, Mary F
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Isaacs, Aaron
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Dehghan, Abbas
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d'Adamo, Pio
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Adeyemo, Adebowa ...
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Dieffenbach, Aid ...
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Zonderman, Alan ...
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Nolte, Ilja M
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van der Most, Pe ...
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Wright, Alan F
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Shuldiner, Alan ...
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Morrison, Alanna ...
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Hofman, Albert
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Smith, Albert V
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Dreisbach, Alber ...
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Franke, Andre
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Uitterlinden, An ...
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Metspalu, Andres
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Tonjes, Anke
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Lupo, Antonio
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Robino, Antoniet ...
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Johansson, Åsa
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Demirkan, Ayse
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Kollerits, Barba ...
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Freedman, Barry ...
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Ponte, Belen
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Oostra, Ben A
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Paulweber, Bernh ...
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Krämer, Bernhard ...
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Mitchell, Braxto ...
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Buckley, Brendan ...
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Peralta, Carmen ...
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Hayward, Carolin ...
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Helmer, Catherin ...
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Rotimi, Charles ...
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Shaffer, Christi ...
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Müller, Christia ...
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Sala, Cinzia
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van Duijn, Corne ...
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Saint-Pierre, Au ...
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Ackermann, Danie ...
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Shriner, Daniel
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Ruggiero, Daniel ...
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Toniolo, Daniela
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Lu, Yingchang
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Cusi, Daniele
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Czamara, Darina
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Ellinghaus, Davi ...
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Siscovick, David ...
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Ruderfer, Dougla ...
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Gieger, Christia ...
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Grallert, Harald
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Rochtchina, Elen ...
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Atkinson, Elizab ...
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Holliday, Elizab ...
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Boerwinkle, Eric
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Salvi, Erika
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Bottinger, Erwin ...
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Murgia, Federico
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Rivadeneira, Fer ...
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Ernst, Florian
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Kronenberg, Flor ...
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Hu, Frank B
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Navis, Gerjan J
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Curhan, Gary C
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Ehret, George B
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Homuth, Georg
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Coassin, Stefan
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Thun, Gian-Andri
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Pistis, Giorgio
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Gambaro, Giovann ...
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Malerba, Giovann ...
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Montgomery, Gran ...
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Eiriksdottir, Gu ...
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Jacobs, Gunnar
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Li, Guo
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Wichmann, H-Eric ...
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Campbell, Harry
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Schmidt, Helena
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Wallaschofski, H ...
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Völzke, Henry
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Brenner, Hermann
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Kroemer, Heyo K
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Kramer, Holly
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Lin, Honghuang
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Mateo Leach, I
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Ford, Ian
-
Guessous, Idris
-
Rudan, Igor
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Prokopenko, Inga
-
Borecki, Ingrid
-
Heid, Iris M
-
Kolcic, Ivana
-
Persico, Ivana
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Jukema, J Wouter
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Wilson, James F
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Felix, Janine F
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Divers, Jasmin
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Lambert, Jean-Ch ...
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Stafford, Jeanet ...
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Gaspoz, Jean-Mic ...
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Smith, Jennifer ...
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Faul, Jessica D
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Wang, Jie Jin
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Ding, Jingzhong
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Hirschhorn, Joel ...
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Attia, John
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Whitfield, John ...
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Chalmers, John
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Viikari, Jorma
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Coresh, Josef
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Denny, Joshua C
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Karjalainen, Juh ...
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Fernandes, Jyoti ...
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Endlich, Karlhan ...
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Butterbach, Katj ...
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Lind, Lars
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Lohman, Kurt
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Portas, Laura
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Launer, Lenore J
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Lyytikäinen, Leo ...
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Yengo, Loic
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Franke, Lude
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Ferrucci, Luigi
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Rose, Lynda M
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Rao, Madhumathi
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Struchalin, Maks ...
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Kleber, Marcus E
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Cavalieri, Margh ...
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Haun, Margot
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Cornelis, Marily ...
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Ciullo, Marina
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Pirastu, Mario
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de Andrade, Mari ...
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McEvoy, Mark A
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Woodward, Mark
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Cocca, Massimili ...
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Nauck, Matthias
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Imboden, Medea
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Waldenberger, Me ...
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Pruijm, Menno
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Sjögren, M.
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Evans, Michele K
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Sale, Michele M
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Kähönen, Mika
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Boban, Mladen
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Bochud, Murielle
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Verweij, Niek
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Martin, Nicholas ...
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Soranzo, Nicole
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Devuyst, Olivier
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Raitakari, Olli
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Franco, Oscar H
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Polasek, Ozren
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Munroe, Patricia ...
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Mitchell, Paul
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Schmidt, Reinhol ...
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Scott, Rodney J
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Katz, Ronit
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Sedaghat, Sanaz
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Wild, Sarah H
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Kardia, Sharon L ...
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Ulivi, Sheila
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Kloiber, Stefan
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Stengel, Benedic ...
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Hancock, Stephen ...
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Turner, Stephen ...
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Rosas, Sylvia E
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Stracke, Sylvia
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Harris, Tamara B
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Zeller, Tanja
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Zemunik, Tatijan ...
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Lehtimäki, Terho
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Illig, Thomas
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Nikopensius, Tii ...
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Tanaka, Toshiko
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Gyllensten, Ulf
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Chen, Wei-Min
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Igl, Wilmar
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März, Winfried
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Koenig, Wolfgang
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Lieb, Wolfgang
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Loos, Ruth J F
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Snieder, Harold
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Pramstaller, Pet ...
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Parsa, Afshin
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O'Connell, Jeffr ...
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Susztak, Katalin
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Hamet, Pavel
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Tremblay, Johann ...
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Hedblad, B.
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Böger, Carsten A
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Goessling, Wolfr ...
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Chasman, Daniel ...
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Köttgen, Anna
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Kao, W H Linda
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Fox, Caroline S
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Fava, C.
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Nilsson, P.
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Nature Communica ...
- By the university
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Uppsala University
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Lund University
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University of Gothenburg