Association between genetic variation on chromosome 9p21 and aneurysmal subarachnoid haemorrhage.

• Genetic factors play a role in susceptibility to subarachnoid haemorrhage, but little is known about which genes are involved. Recently, genome wide association studies have identified the 9p21 region as a risk locus for intracranial aneurysms (IA). The aim of the present study was to examine the possible association between 9p21 and ruptured IA--that is, aneurysmal subarachnoid haemorrhage (aSAH)--in a Swedish population. There is one study showing an association between 9p21 and arterial stiffness, and arterial stiffness plays a role in the development of hypertension. Therefore, a second aim was to investigate whether a putative association is independent of hypertension.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Adult

Aged

Aged

80 and over

Alleles

Aneurysm

Ruptured

complications

genetics

Chromosomes

Human

Pair 9

Female

Genetic Predisposition to Disease

Genome-Wide Association Study

Genotype

Humans

Hypertension

complications

genetics

Intracranial Aneurysm

complications

genetics

Male

Middle Aged

Polymorphism

Single Nucleotide

Risk Factors

Smoking

genetics

Subarachnoid Hemorrhage

complications

genetics

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)