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Three exceptional I...
Three exceptional IgH/myc-translocation-carrying rat immunocytomas have breakpoints 50 to 80 kb 5' of c-myc
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- Axelson, H (författare)
- Karolinska Institutet,Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine
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Panda, C K (författare)
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Klein, G (författare)
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(creator_code:org_t)
- 1994
- 1994
- Engelska.
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Ingår i: International Journal of Cancer. - 0020-7136. ; 56:3, s. 21-418
- Relaterad länk:
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https://lup.lub.lu.s...
Abstract
Ämnesord
Stäng
- The spontaneously arising immunocytoma of the Louvain rat (RIC) carries a consistent chromosomal translocation between chromosomes 6 and 7. This translocation juxtaposes immunoglobulin heavy chain and c-myc sequences. In an earlier study on 14 RIC tumors, we found that the translocation breakpoint is located within 1.5 kb immediately upstream of c-myc in 10 of the tumors. Here we describe 3 exceptional tumors that had no rearrangement within 20 kb 5' of c-myc. Using pulsed-field gel electrophoresis we show that the translocation breakpoints in these tumors are located 50-80 kb 5' of c-myc and that c-myc rearranges to the 3' end of the IgH cluster.
Nyckelord
- Animals
- Cell Line
- Chromosome Mapping
- DNA, Neoplasm
- Genes, Immunoglobulin
- Genes, myc
- Immunoglobulin Heavy Chains
- Leukemia, Lymphocytic, Chronic, B-Cell
- Multigene Family
- Rats
- Rats, Inbred Strains
- Restriction Mapping
- Translocation, Genetic
- Tumor Cells, Cultured
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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