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00005759naa a2200481 4500
008160401s2013 | |||||||||||000 ||eng|
024a https://lup.lub.lu.se/record/40336902 URI
024a https://doi.org/10.1210/jc.2013-20002 DOI
024a urn:nbn:se:liu:diva-972422 urn
040 a (SwePub)lud (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Fjalldal, Sigriduru Skåne University Hospital, Sweden4 aut
2451 0a Hypothalamic Involvement Predicts Cognitive Performance and Psychosocial Health in Long-term Survivors of Childhood Craniopharyngioma
264 1b Oxford University Press,c 2013
500 a Funding Agencies|Swedish Research Council|K 2008-54X-20643-01-3|Swedish Childrens Cancer Foundation||Medical Faculty, Lund University, Sweden||Pfizer||Eli Lilly||
520 a Context: Hypothalamic damage caused by craniopharyngioma (CP) is associated with poor functional outcome. Objective: To assess cognitive function and quality of life in childhood-onset CP on hormonal replacement, including GH treatment. Design: A cross-sectional study with a median follow-up time of 20 years (1-40). Setting: Patients were recruited from the South Medical Region of Sweden. Participants: The study included 42 patients (20 women) surgically treated for a childhood-onset CP between 1958 and 2000. Patients were aged >= 17 years. Equally many controls, matched for age, sex, residence, and smoking habits, were included. Tumor growth into the third ventricle was found in 25 patients. Main Outcome Measures: All subjects were examined with a battery of cognitive tests and the following questionnaires: Symptom Checklist-90, the Interview Schedule for Social Interaction, and the Social Network concept. Results: The CP patients had lower cognitive performance, reaching statistical significance in 12 of 20 test variables, including executive function and memory. Comparison of patients with tumor growth into the third ventricle to controls revealed a significant lower mean total score (P = .006). A significant negative correlation was recorded between mean z-score of cognitive performance and years since operation (r = -0.407; P = .014). No statistically significant group differences were observed across any of the 9 Symptom Checklist-90 subscales. Conclusions: Adults with childhood-onset CP, on hormone replacement, including GH treatment, have memory defects, disturbed attention, and impaired processing speed. Patients with hypothalamic involvement are more affected. Patients rated their quality of life as good as their matched controls.
650 7a SAMHÄLLSVETENSKAPx Psykologi0 (SwePub)5012 hsv//swe
650 7a SOCIAL SCIENCESx Psychology0 (SwePub)5012 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
700a Holmer, Heleneu Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Central Hospital Kristianstad, Sweden4 aut0 (Swepub:lu)med-hho
700a Rylander, Larsu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund University, Sweden4 aut0 (Swepub:lu)ymed-lry
700a Elfving, Mariau Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital, Sweden4 aut0 (Swepub:lu)pedi-mel
700a Ekman, Bertilu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Endokrinmedicinska kliniken4 aut
700a Österberg, Kaiu Lund University,Lunds universitet,Institutionen för psykologi,Samhällsvetenskapliga institutioner och centrumbildningar,Samhällsvetenskapliga fakulteten,Department of Psychology,Departments of Administrative, Economic and Social Sciences,Faculty of Social Sciences,Lund University, Sweden4 aut0 (Swepub:lu)ymed-kos
700a Erfurth, Eva Marieu Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital, Sweden4 aut0 (Swepub:lu)med-ee0
710a Skåne University Hospital, Swedenb Medicin, Lund4 org
773t Journal of Clinical Endocrinology and Metabolismd : Oxford University Pressg 98:8, s. 3253-3262q 98:8<3253-3262x 1945-7197x 0021-972X
856u http://dx.doi.org/10.1210/jc.2013-2000y FULLTEXT
856u https://academic.oup.com/jcem/article-pdf/98/8/3253/10781221/jcem3253.pdf
8564 8u https://lup.lub.lu.se/record/4033690
8564 8u https://doi.org/10.1210/jc.2013-2000
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-97242x lärosäteslänky Till lärosätets (liu) databas

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