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Preserved Hippocamp...
Preserved Hippocampus Activation in Normal Aging as Revealed by fMRI
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- Persson, Jonas (författare)
- Stockholms universitet,Psykologiska institutionen,Department of Psychology, Stockholm University, 106 91 Stockholm, Sweden
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- Kalpouzos, Gregoria (författare)
- Umeå universitet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Fysiologi
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- Nilsson, Lars-Göran (författare)
- Stockholms universitet,Psykologiska institutionen,Department of Psychology, Stockholm University, 106 91 Stockholm, Sweden
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- Ryberg, Mats (författare)
- Umeå universitet,Medicin
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- Nyberg, Lars, 1966- (författare)
- Umeå universitet,Diagnostisk radiologi,Fysiologi
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(creator_code:org_t)
- 2010-05-17
- 2011
- Engelska.
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Ingår i: Hippocampus. - : Wiley. - 1050-9631 .- 1098-1063. ; 21:7, s. 753-766
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The hippocampus is deteriorated in various pathologies such as Alzheimer's disease (AD) and such deterioration has been linked to memory impairment. By contrast, the structural and functional effects of normal aging on the hippocampus is a matter of debate, with some findings suggesting deterioration and others providing evidence of preservation. This constitutes a crucial question since many investigations on AD are based on the assumption that the deterioration of the hippocampus is the breaking point between normal and pathological aging. A growing number of fMRI studies specifically aimed at investigating hippocampal engagement in various cognitive tasks, notably memory tasks, but the results have been inconclusive. Here, we optimized the episodic face-name paired-associates task in order to test the functioning of the hippocampus in normal aging. Critically, we found no difference in the activation of the hippocampus between the young and a group of older participants. Analysis of individual patterns of activation substantiated this impression. Collectively, these findings provide evidence of preserved hippocampal functioning in normal aging.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- aging
- episodic memory
- functional MRI
- Hippocampus
- Psychology
- Psykologi
- psykologi
- Psychology
- Psychology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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