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Cortical Processing...
Cortical Processing of Multimodal Sensory Learning in Human Neonates
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- Dall'orso, Sofia, 1992 (author)
- Imperial College of Science, Technology and Medicine,King's College London,Chalmers tekniska högskola,Chalmers University of Technology
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- Fifer, W. P. (author)
- Columbia University in the City of New York
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- Balsam, P. D. (author)
- Columbia University in the City of New York
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- Brandon, J. (author)
- King's College London
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- O'Keefe, C. (author)
- King's College London
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- Poppe, T. (author)
- King's College London
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- Vecchiato, K. (author)
- King's College London
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- Edwards, A. D. (author)
- Imperial College of Science, Technology and Medicine,King's College London
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- Burdet, E. (author)
- Imperial College of Science, Technology and Medicine
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- Arichi, Tomoki (author)
- Imperial College of Science, Technology and Medicine,King's College London,Evelina London Children's Healthcare
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(creator_code:org_t)
- 2020-11-18
- 2021
- English.
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In: Cerebral Cortex. - : Oxford University Press (OUP). - 1047-3211 .- 1460-2199. ; 31:3, s. 1827-1836
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Abstract
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- Following birth, infants must immediately process and rapidly adapt to the array of unknown sensory experiences associated with their new ex-utero environment. However, although it is known that unimodal stimuli induce activity in the corresponding primary sensory cortices of the newborn brain, it is unclear how multimodal stimuli are processed and integrated across modalities. The latter is essential for learning and understanding environmental contingencies through encoding relationships between sensory experiences; and ultimately likely subserves development of life-long skills such as speech and language. Here, for the first time, we map the intracerebral processing which underlies auditory-sensorimotor classical conditioning in a group of 13 neonates (median gestational age at birth: 38 weeks + 4 days, range: 32 weeks + 2 days to 41 weeks + 6 days; median postmenstrual age at scan: 40 weeks + 5 days, range: 38 weeks + 3 days to 42 weeks + 1 days) with blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (MRI) and magnetic resonance (MR) compatible robotics. We demonstrate that classical conditioning can induce crossmodal changes within putative unimodal sensory cortex even in the absence of its archetypal substrate. Our results also suggest that multimodal learning is associated with network wide activity within the conditioned neural system. These findings suggest that in early life, external multimodal sensory stimulation and integration shapes activity in the developing cortex and may influence its associated functional network architecture.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- brain plasticity
- functional MRI
- classical conditioning
- neonate
- multisensory integration
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Dall'orso, Sofia ...
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Fifer, W. P.
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Balsam, P. D.
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Brandon, J.
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O'Keefe, C.
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Poppe, T.
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show more...
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Vecchiato, K.
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Edwards, A. D.
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Burdet, E.
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Arichi, Tomoki
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show less...
- About the subject
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
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and Psychology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Cerebral Cortex
- By the university
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Chalmers University of Technology