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Inflammatory mediat...
Inflammatory mediator profiling of n-butanol exposed upper airways in individuals with multiple chemical sensitivity
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- Meinertz Dantoft, Thomas (författare)
- Danish Research Centre for Chemical Sensitivities, Copenhagen University Hospital, Gentofte, Denmark; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark
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- Skovbjerg, Sine (författare)
- Research Centre for Prevention and Health, Capital Region, Copenhagen, Denmark
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- Andersson, Linus (författare)
- Umeå universitet,Högskolan i Gävle,Arbetshälsovetenskap,Centrum för belastningsskadeforskning,Department of Psychology, Umeå University, Umeå, Sweden,Institutionen för psykologi,Department of Occupational and Public Health Sciences, University of Gävle, Sweden
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- Claeson, Anna-Sara, 1974- (författare)
- Umeå universitet,Institutionen för psykologi,Department of Psychology, Umeå University, Umeå, Sweden
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- Lind, Nina, 1989- (författare)
- Umeå universitet,Institutionen för psykologi,Department of Psychology, Umeå University, Umeå, Sweden
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- Nordin, Steven (författare)
- Umeå universitet,Institutionen för psykologi,Department of Psychology, Umeå University, Umeå, Sweden
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- Brix, Susanne (författare)
- Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark
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(creator_code:org_t)
- 2015-11-23
- 2015
- Engelska.
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 10:11
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND: Multiple Chemical Sensitivity (MCS) is a chronic condition characterized by reports of recurrent symptoms in response to low level exposure to various chemical substances. Recent findings suggests that dysregulation of the immune system may play a role in MCS pathophysiology.OBJECTIVES: The aim of this study was to examine baseline and low dose n-butanol-induced upper airway inflammatory response profiles in MCS subjects versus healthy controls.METHOD: Eighteen participants with MCS and 18 age- and sex-matched healthy controls were enrolled in the study. Epithelial lining fluid was collected from the nasal cavity at three time points: baseline, within 15 minutes after being exposed to 3.7 ppm n-butanol in an exposure chamber and four hours after exposure termination. A total of 19 cytokines and chemokines were quantified. Furthermore, at baseline and during the exposure session, participants rated the perceived intensity, valence and levels of symptoms and autonomic recordings were obtained.RESULTS: The physiological and psychophysical measurements during the n-butanol exposure session verified a specific response in MCS individuals only. However, MCS subjects and healthy controls displayed similar upper airway inflammatory mediator profiles (P>0.05) at baseline. Likewise, direct comparison of mediator levels in the MCS group and controls after n-butanol exposure revealed no significant group differences.CONCLUSION: We demonstrate no abnormal upper airway inflammatory mediator levels in MCS subjects before or after a symptom-eliciting exposure to low dose n-butanol, implying that upper airways of MCS subjects are functionally intact at the level of cytokine and chemokine production and secretory capacity. This suggests that previous findings of increased cytokine plasma levels in MCS are unlikely to be caused by systemic priming via excessive upper airway inflammatory processes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- inflammation
- chemokine
- cytokines
- immune response
- secretion
- odorants
- inflammatory diseases
- sensory perception
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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