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Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer : a Mendelian Randomization analysis using data from three large cohort studies
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- Nimptsch, Katharina (författare)
- Max Delbrück Center for Molecular Medicine (MDC),Harvard University
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- Song, Mingyang (författare)
- Harvard University
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- Aleksandrova, Krasimira (författare)
- German Institute of Human Nutrition
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- Katsoulis, Michail (författare)
- Hellenic Health Foundation, Athens,Farr Institute of Health Informatics Research
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- Freisling, Heinz (författare)
- International Agency for Research on Cancer, World Health Organization
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer, World Health Organization,Imperial College London
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer, World Health Organization,Max Delbrück Center for Molecular Medicine (MDC)
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- Tsilidis, Konstantinos K. (författare)
- Imperial College London,University of Ioannina
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- Weiderpass, Elisabete (författare)
- Karolinska Institutet,Karolinska Institute,Cancer Registry of Norway, Institute of Population-Based Cancer Research,UiT The Arctic University of Norway, Tromsø,Folkhälsan Research Center
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- Bueno-De-Mesquita, H. Bas (författare)
- Imperial College London,University of Malaya,National Institute for Public Health and the Environment (RIVM)
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- Chong, Dawn Q. (författare)
- National Cancer Centre Singapore
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- Jensen, Majken K. (författare)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
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- Wu, Chunsen (författare)
- University of Southern Denmark,Aarhus University,Odense University Hospital
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- Overvad, Kim (författare)
- Aarhus University
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- Kuehn, Tilman (författare)
- German Cancer Research Centre
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- Barrdahl, Myrto (författare)
- German Cancer Research Centre
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Jirström, Karin (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Peeters, Petra H. (författare)
- Imperial College London,University Medical Center Utrecht
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- Sieri, Sabina (författare)
- Istituto Nazionale dei Tumori,Brigham and Women's Hospital / Harvard Medical School,Dana-Farber Cancer Institute
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- Panico, Salvatore (författare)
- University of Naples Federico II
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Cross, Amanda J. (författare)
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- Riboli, Elio (författare)
- Imperial College London
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- Van Guelpen, Bethany (författare)
- Umeå University,Umeå universitet,Onkologi
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- Myte, Robin (författare)
- Umeå University,Umeå universitet,Onkologi
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- Maria Huerta, Jose (författare)
- Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
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- Rodriguez-Barranco, Miguel (författare)
- CIBER Epidemiology and Public Health (CIBERESP),University of Granada
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- Ramon Quiros, Jose (författare)
- Public Health Directorate
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- Dorronsoro, Miren (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Tjonneland, Anne (författare)
- Danish Cancer Society
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- Olsen, Anja (författare)
- Danish Cancer Society
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- Travis, Ruth (författare)
- University of Oxford
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- Boutron-Ruault, Marie-Christine (författare)
- University of Paris-Saclay
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- Carbonnel, Franck (författare)
- University of Paris-Saclay
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- Severi, Gianluca (författare)
- University of Melbourne,University of Paris-Saclay,Human Genetics Foundation (HuGeF)
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- Bonet, Catalina (författare)
- Catalan Institute of Oncology
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- Palli, Domenico (författare)
- Cancer Research and Prevention Institute (ISPO)
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Janke, Juergen (författare)
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- Lee, Young-Ae (författare)
- Max Delbrück Center for Molecular Medicine (MDC)
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Giovannucci, Edward L. (författare)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
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- Ogino, Shuji (författare)
- Dana-Farber Cancer Institute,Harvard University,Brigham and Women's Hospital / Harvard Medical School
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Fuchs, Charles S. (författare)
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- Rimm, Eric (författare)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
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- Wu, Kana (författare)
- Harvard University
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- Chan, Andrew T. (författare)
- Broad Institute,Brigham and Women's Hospital / Harvard Medical School
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- Pischon, Tobias (författare)
- Max Delbrück Center for Molecular Medicine (MDC),Charité - University Medicine Berlin
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(creator_code:org_t)
- 2017-05-26
- 2017
- Engelska.
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Ingår i: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 32:5, s. 419-430
- Relaterad länk:
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https://europepmc.or...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case-control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 matched controls), the Health Professionals Follow-up Study (HPFS, 231 cases, 230 controls) and the Nurses' Health Study (NHS, 399 cases, 774 controls) with available data on pre-diagnostic adiponectin concentrations and selected single nucleotide polymorphisms in the ADIPOQ gene. We created an ADIPOQ allele score that explained approximately 3% of the interindividual variation in adiponectin concentrations. The ADIPOQ allele score was not associated with risk of colorectal cancer in logistic regression analyses (pooled OR per score-unit unit 0.97, 95% CI 0.91, 1.04). Genetically determined twofold higher adiponectin was not significantly associated with risk of colorectal cancer using the ADIPOQ allele score as instrumental variable (pooled OR 0.73, 95% CI 0.40, 1.34). In a summary instrumental variable analysis (based on previously published data) with higher statistical power, no association between genetically determined twofold higher adiponectin and risk of colorectal cancer was observed (0.99, 95% CI 0.93, 1.06 in women and 0.94, 95% CI 0.88, 1.01 in men). Thus, our study does not support a causal effect of circulating adiponectin on colorectal cancer risk. Due to the limited genetic determination of adiponectin, larger Mendelian Randomization studies are necessary to clarify whether adiponectin is causally related to lower risk of colorectal cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Adiponectin
- ADIPOQ
- Colorectal cancer
- Mendelian Randomization
- Adiponectin
- ADIPOQ
- Colorectal cancer
- Mendelian Randomization
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- Av författaren/redakt...
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Nimptsch, Kathar ...
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Song, Mingyang
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Aleksandrova, Kr ...
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Katsoulis, Micha ...
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Freisling, Heinz
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Jenab, Mazda
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visa fler...
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Gunter, Marc J.
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Tsilidis, Konsta ...
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Weiderpass, Elis ...
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Bueno-De-Mesquit ...
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Chong, Dawn Q.
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Jensen, Majken K ...
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Wu, Chunsen
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Overvad, Kim
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Kuehn, Tilman
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Barrdahl, Myrto
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Melander, Olle
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Jirström, Karin
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Peeters, Petra H ...
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Sieri, Sabina
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Panico, Salvator ...
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Cross, Amanda J.
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Riboli, Elio
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Van Guelpen, Bet ...
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Myte, Robin
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Maria Huerta, Jo ...
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Rodriguez-Barran ...
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Ramon Quiros, Jo ...
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Dorronsoro, Mire ...
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Tjonneland, Anne
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Olsen, Anja
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Travis, Ruth
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Boutron-Ruault, ...
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Carbonnel, Franc ...
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Severi, Gianluca
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Bonet, Catalina
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Palli, Domenico
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Janke, Juergen
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Lee, Young-Ae
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Boeing, Heiner
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Giovannucci, Edw ...
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Ogino, Shuji
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Fuchs, Charles S ...
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Rimm, Eric
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Wu, Kana
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Chan, Andrew T.
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Pischon, Tobias
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
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European Journal ...
- Av lärosätet
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Umeå universitet
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Lunds universitet
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Karolinska Institutet